Immunocytochemical studies of the brain in intact Wistar rats (n = 5) addressed the localization of α-synuclein (α-Syn), which is a protein presented in Lewy bodies in Parkinson's disease (PD), and tyrosine hydroxylase, a marker of dopaminergic and noradrenergic neurons, in comparison with data obtained after lesioning of the substantia nigra (n = 3). The localization of α-Syn in synaptic structures in the basal nuclei corresponded to corticostriate and strionigral projections, which was confirmed experimentally. The bodies of dopaminergic and noradrenergic neurons in the substantia nigra, locus ceruleus, and dorsal nucleus of the vagus nerve were found to contain α-Syn – these are structures which undergo neurodegeneration in PD. Sensory olfactory neurons and glomeruli in the olfactory bulbs also had high α-Syn contents.
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