Foci of epileptic activity, generated as a result of synchronization of periodic burst discharges in neuronal networks, are often localized in the hippocampus. Using a model approach, we investigated the possibility of and biophysical conditions for the appearance of local oscillatory processes in dendrites possessing voltage-dependent channels (which is typical of pyramidal neurons of the hippocampus). The study was performed on a computer model of the membrane with active conductivities inherent in dendrites of pyramidal neurons of the CA3 area. It was found that such a membrane compartment subjected to tonic synaptic excitatory influences can function as a local generator of stable depolarization of a low or a high level or as a generator producing membrane potential oscillations (local oscillator). Each of these modes corresponds to a certain range of the synaptic excitation intensity; with increasing temperature, the range within which the oscillator properties are manifested is narrowed, while the range within which high-level stable depolarization is generated is expanded.
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