Axonal excitability changes and acute symptoms of oxaliplatin treatment: in vivo evidence for slowed sodium channel inactivation

Oxaliplatin is a third-generation platinum analog used for the treatment of solid cancers, in particular as primary and adjuvant treatment of advanced and high-risk colorectal cancer (DCCG, 2015). Neurotoxicity is a frequent and often dose-limiting side effect of oxaliplatin treatment (Gamelin et al., 2002; Argyriou et al., 2013). Oxaliplatin is unique among platinum analogs, as it induces two clinically different types of peripheral neuropathy. One type is a commonly occurring acute neurotoxicity with transient paresthesia, typically triggered by cold exposure, and muscle spasms in the limbs and jaw.

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