Presurgical language mapping using event-related high-gamma activity: the Detroit procedure

The ultimate goal of epilepsy surgery is to completely remove the epileptogenic zone while maximally preserving functionally-important brain areas including the primary language areas (Asano et al., 2013). In case noninvasive evaluation fails to satisfactorily localize these areas of interest, invasive presurgical evaluation is often employed with intracranial electrodes placed on the affected hemisphere for days to weeks (Lesser et al., 2010). The seizure onset zone responsible for habitual seizures and the spatial extent of neuroimaging abnormalities are determined for localization of the epileptogenic zone (Asano et al., 2009).

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