Mechanisms of Fatigue and Recovery in Upper versus Lower Limbs in Men.

Purpose: To compare the mechanisms of fatigue and recovery between upper and lower limbs in the same subjects. Methods: Twelve healthy young males performed a 2-min sustained maximal voluntary isometric contraction (MVC) of the knee extensors (KE) and on another day a 2-min MVC of the elbow flexors (EF). Neuromuscular function evaluations were performed with both transcranial magnetic and peripheral stimulations before (PRE), at the end of the 2-min MVCs (POSTimm), and 5 more times within 8 min of recovery. Results: Decreases in MVC and cortical voluntary activation were ~12% (P 0.05) whereas the increase in silent period duration was ~30% greater in EF than KE (P

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