iMAX: a new tool to assess peripheral motor axonal hypoexcitability

In routine electrodiagnostic procedures, classical parameters allow assessment of motor unit loss/reinnervation (CMAP amplitude) and motor conduction slowing (motor distal latency, motor conduction velocity, F waves), but none evaluates peripheral motor axon hypoexcitability. Yet everyone has experienced that in a demyelinating neuropathy it is often necessary to increase above normal the amount of current to obtain a supramaximal motor response. Excitability properties of human peripheral nerves can be assessed by various neurophysiological methods (Brismar, 1985; Kiernan et al, 2000; Burke et al, 2001), but they are not often used in daily practice because they are time consuming and they require a specific collection system and software.

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