A Method for the Topographical Identification and Quantification of High Frequency Oscillations in Intracranial Electroencephalography Recordings

Up to one third of patients with focal seizures are medically refractory, and resective epilepsy surgery or responsive nerve stimulation (RNS) placement is required to reduce seizure burden or render the patient seizure free (Wiebe et al., 2001; Engel et al., 2012). High Frequency Oscillations (HFOs) consist of brief (<200 μsec) bursts of energy with a spectral content ranging between 80-600 Hz and have shown promise as a electrophysiological biomarker of epileptogenic brain tissue (Engel et al., 2009; Gotman, 2010; Jacobs et al., 2012).

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