Short term dietary curcumin supplementation reduces gastrointestinal barrier damage and physiological strain responses during exertional heat stress

Purpose: This work investigated the effect of 3d of 500mg/d dietary curcumin supplementation on gastrointestinal (GI) barrier damage and systems-physiology responses to exertional heat stress in non-heat acclimated humans. Methods: Eight participants ran (65%VO_2max) for 60min in a Darwin® chamber (37°C/25%RH) two times (Curcumin/Placebo). Intestinal fatty acid binding protein (I-FABP) and associated pro-inflammatory (MCP-1, TNFα, IL-6) and anti-inflammatory (IL-1RA, IL-10) cytokines were assayed from plasma collected before (Pre), after (Post), 1hr (1-Post), and 4hrs after (4-Post) exercise. Core temperature and HR were measured throughout exercise; the Physiological Strain Index (PSI) was calculated from these variables. Condition differences were determined with 2-Way (Condition x Time) RM ANOVAs. Results: The interaction of Condition x Time was significant (p=0.05) for I-FABP and IL-1RA. Post hoc analysis indicated I-FABP increased more from Pre to Post (87%) and 1-Post (33%) in Placebo than in Curcumin (58% & 18%, respectively). IL-1RA increased more from Pre to 1-Post in Placebo (153%) than in Curcumin (77%). TNFα increased (p=0.01) from Pre to Post (19%) and 1-Post (24%) in Placebo but not in Curcumin (p>0.05). IL-10 increased (p<0.01) from Pre to Post (61%) and 1-Post (42%) in Placebo not in Curcumin (p>0.05). The PSI, which indicates exertional heatstroke (EHS) risk, was also lower (p<0.01) in Curcumin than Placebo from 40-60 min of exercise. Conclusion: These data suggest 3d curcumin supplementation may improve GI function, associated cytokines, and systems-level physiology responses during exertional heat stress. This could help reduce EHS risk in non-heat acclimated individuals.

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