Pallidal low β-low γ phase-amplitude coupling inversely correlates with Parkinson disease symptoms

β oscillatory activity (13-30 Hz) throughout the basal ganglia-thalamo-cortical (BGTC) motor network has been suggested to contribute to the pathophysiology and serve as a biomarker of Parkinson disease (PD) (Brittain and Brown, 2014; Brown, 2003; Crowell et al., 2012; Eusebio and Brown, 2007; Hammond et al., 2007; de Hemptinne et al., 2015; Kuhn et al., 2009; Little and Brown, 2014; Oswal et al., 2013; Weinberger et al., 2006). STN β power has been shown to be related to severity of rigidity and bradykinesia symptoms and to decrease in proportion to clinical improvement with treatment (Chen et al., 2010; Eusebio et al., 2011; Levy et al., 2002).

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