Immunosuppressant Medication Induced Lower Extremity Pain after Combined Liver and Kidney Transplant: A Case Report

Calcineurin inhibitors are imperative in the success of a transplanted organ. However, these immunosuppressants can lead to a rare complication known as calcineurin inhibitor induced pain syndrome (CIPS), which may not be recognized early and managed appropriately. We present a case of a 35-year-old female who underwent a combined liver/kidney transplant and developed lower extremity pain while being maintained on tacrolimus. This case illustrates a patient with previously reported characteristic clinical features of CIPS in addition to uncharacteristic neuropathic symptoms and imaging findings.

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