Reactions of Microglial Cells in the Sensorimotor Cortex of Rats after Transient Ischemia

Blood supply disturbances in the cortex after carotid ligation or microembolization of the vessels of the hemisphere by adipocytes result in an increase in the number of Iba-1+ microgliocytes in the hemisphere; the intensity of such increase depends on the degree of ischemic damage. The reaction of microglia to this damage shows a systemic character, since it is also manifested in cortical parts that did not directly undergo destructive (necrotic) changes and were beyond the zones of ischemization. An immunomodulator, Immunofan, increased the number of Iba-1+ microgliocytes within the acute period after transitory ischemia; within the recovery period, their number significantly decreased. This coincided with the more favorable time course of the postischemic process as a whole. The latter phenomenon can be considered a manifestation of the neuroprotective properties of Immunofan.

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