P218 Motor cortical adaptation to external stimuli is altered in unverricht-lundborg type myoclonus epilepsy

Unverricht-Lundborg disease, or progressive myoclonus epilepsy type 1 (EPM1), affects cortical excitability and inhibition, and neuroanatomy of the thalamocortical system. Stimulus sensitive myoclonus with potentially disabling features associates with EPM1. Our objective was to assess neurophysiological adaptation in EPM1 to further understand the role of the impaired thalamocortical system in the characteristic features of the disease.

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