P1-12. L-DOPA may modify function of the sensory cortex in Parkinson’s disease

Publication date: September 2017
Source:Clinical Neurophysiology, Volume 128, Issue 9
Author(s): Nobuyuki Ishii, Hitoshi Mochizuki, Kazutaka Shiomi, Masamitsu Nakazato
Sensory disturbance is occasionally accompanied with parkinsonism and is sometimes improved by L-DOPA treatment. The abnormalities in cerebral somatosensory neurons were already revealed by neurophysiological methods. However, whether L-DOPA influences the cerebral somatosensory functions is unknown. We evaluated the effect of L-DOPA on the sensory cortex in Parkinson disease (PD) using neurophysiological technique such as high-frequency oscillations (HFOs) and somatosensory evoked potential recovery functions (SEP-Rs), which could detect slight functional abnormalities of cerebral somatosensory interneurons. We examined ten drug-naïve PD patients in pre- and post-L-DOPA treatment. HFOs were obtained by digitally filtering raw SEPs from 500 to 1000Hz. For SEP-Rs study, paired-pulse stimuli at various interstimulus intervals (ISIs; 20–200ms) were given. There were no significant differences in the HFO study. The SEP-Rs study demonstrated that patients with disease duration of more than one year (n=6) had a significant disinhibition (P=0.003) in P25-N33 of post-treatment compared with pre-treatment. L-DOPA may have some effects on the abnormal GABAergic interneuron function in sensory cortex, which could improve sensory disturbance by L-DOPA therapy in PD patients.



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