O-2-6-26. Effects of sleep on the epileptiform discharge in benign adult familial myoclonus epilepsy (BAFME)

Publication date: September 2017
Source:Clinical Neurophysiology, Volume 128, Issue 9
Author(s): Takefumi Hitomi, Katsuya Kobayashi, Takeyo Sakurai, Shamima Sultana, Kei Sato, Takeshi Inoue, Akihiro Shimotake, Riki Matsumoto, Ryosuke Takahashi, Akio Ikeda
Epileptiform discharges often increase in most epilepsy types. This study sought to clarify the effects of sleep modification on cortical irritability in benign adult familial myoclonus epilepsy (BAFME). We retrospectively reviewed 31 conventional electroencephalographies (EEGs) of 12 BAFME patients and analyzed epileptiform discharges during the awake and sleep periods of 6 EEGs in 5 BAFME patients (5 women, mean age: 49.6±20.3years). Using conventional EEG analysis, EEG was classified into awake (66.6%) and light sleep stages (Stage I and II) (33.4%). Epileptiform discharges were significantly more frequent during the awake (1.3±1.2/min) period than light sleep stages (0.02±0.04/min) (P<0.05). Our study showed that epileptiform discharges were consistently reduced during sleep in patients with BAFME, which indicated a reduction in cortical irritability during the sleep period. Unverricht-Lundborg disease, a relatively milder form of progressive myoclonus epilepsy, showed a similar trend, thus BAFME and ULD may share a similar pathological mechanism of cortical irritability in response to a change in vigilance.



from Physiology via xlomafota13 on Inoreader http://ift.tt/2vGWX6X
via IFTTT