Mitophagy in maintaining skeletal muscle mitochondrial proteostasis and metabolic health with aging

Abstract

Skeletal muscle is important for overall functionality and health. Aging is associated with an accumulation of damage to mitochondria DNA and proteins. In particular, damage to mitochondrial proteins in skeletal muscle, which is a loss of mitochondrial proteostasis, contributes to tissue dysfunction and negatively impacts systemic health. Therefore, understanding the mechanisms underlying the regulation of mitochondrial proteostasis and how those mechanisms change with age is important for the development of interventions to promote healthy aging. Herein, we examine how impairment in the selective degradation of damaged/dysfunctional mitochondria through mitophagy may play a central role in the loss of mitochondrial proteostasis in skeletal muscle aging as well as its broader implications for systemic health. Further, we explore how stimulating mitophagy through exercise may promote healthy aging.

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