Purpose: Endurance exercise increases indices of small intestinal damage and leucine oxidation, which may attenuate dietary amino acid appearance and postprandial leucine balance during postexercise recovery. Therefore, the purpose of this study was to examine the impact of an acute bout of endurance exercise on postprandial leucine kinetics and net leucine balance. Methods: In a crossover design, seven trained young men (age = 25.6 +/- 2.3 y; VO2peak = 61.4 +/- 2.9 ml[middle dot]kg-1[middle dot]min-1; mean +/- SEM) received a primed constant infusion of L-[1-13C]leucine before and after ingesting a mixed macronutrient meal containing 18 g whole egg protein intrinsically labeled with L-[5,5,5-2H3]leucine, 17 g fat, and 60 g carbohydrate at rest and after 60 min of treadmill running at 70% VO2peak. Results: Plasma intestinal fatty acid binding protein concentrations and leucine oxidation both increased (P
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