Prolongation of Terminal Latency of the Phrenic Nerve in Amyotrophic Lateral Sclerosis – Is it Clinically Useful, and what are the Mechanisms?

I read with interest the manuscript "The terminal latency of the phrenic nerve correlated with respiratory symptoms in amyotrophic lateral sclerosis" (this issue) by Park and Park, concluding that distal latency is the best parameter of phrenic nerve conduction to indicate early respiratory impairment in amyotrophic lateral sclerosis (ALS) patients. They investigated 23 ALS patients, split in 2 groups as defined by respiratory subscore of ALSFRS-R scale, each with a very small number of subjects (12 and 11).

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