Functional variomics and network perturbation: connecting genotype to phenotype in cancer

Nature Reviews Genetics 18, 395 (2017). doi:10.1038/nrg.2017.8

Authors: Song Yi, Shengda Lin, Yongsheng Li, Wei Zhao, Gordon B. Mills & Nidhi Sahni

Proteins interact with other macromolecules in complex cellular networks for signal transduction and biological function. In cancer, genetic aberrations have been traditionally thought to disrupt the entire gene function. It has been increasingly appreciated that each mutation of a gene could have a subtle but

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