The treatment of Alzheimer disease has continued to develop during the past decade. Although an acetylcholine esterase (AchE) inhibitor has been widely used for the treatment of cognitive function in patients with Alzheimer disease through an enhancement of cholinergic function, an open-channel blockade agent targeted for N-methyl-d-aspartate (NMDA) has recently been established as a novel treatment of Alzheimer disease, namely, memantine. Memantine reduced clinical deterioration in moderate-to-severe Alzheimer disease.
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