Temporal-spatial characteristics of phase-amplitude coupling in electrocorticogram for human temporal lobe epilepsy

Abnormal discharge of neurons in the epileptic human brain causes the specificity of the neural oscillations of the cerebral cortex. The low-frequency and high-frequency neural oscillations of some frequency bands have been known as the essential biomarkers of the epileptogenicity and epileptic seizure-onset zones. The dynamic process of very low frequency oscillations (LFOs) in the intracranial electroencephalographic recordings has been found to occur during the preictal state in the refractory epilepsy patients (Ren et al., 2011).

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