Seizure prediction in patients with focal hippocampal epilepsy

Epilepsy is a neurological disorder affecting 1% of the world's population. It causes seizures characterized by recurrent synchronous abnormal electrical discharges in the brain (Chaovalitwongse et al. 2006; Browne and Holmes 2008). Epileptic patients are often at high risk of serious injury or death (Cockerell et al. 1994). Moreover, accompanying psychological stress and helplessness can cause impaired everyday functioning (Buck et al. 1997; Baker et al. 1997). Thereby, reliable prediction of seizures can considerably improve the quality of life of epileptic patients by warning them of impeding seizures to avoid potentially dangerous situations like driving or swimming and enable administration of treatments (Cook et al., 2013; Ramgopal et al., 2014).

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