Calculated versus Measured MVV-Surrogate Marker of Ventilatory Capacity in Pediatric CPET.

Introduction: Maximum Voluntary Ventilation (MVV), a surrogate marker of maximum ventilatory capacity, allows for measuring ventilatory reserve during Cardiopulmonary Exercise Stress Testing (CPET) which is necessary to assess ventilatory limitation. MVV can be measured directly during a patient maneuver or indirectly by calculating from FEV1 (FEV1 X 40). We investigated for a potential difference between calculated MVV and measured MVV in pediatric subjects, and which better represents maximum ventilatory capacity during CPET. Methods: Data was collected retrospectively from CPET done in pediatric subjects for exercise induced dyspnea from Jan 2014 to June 2015 at Akron Children's Hospital. Subjects with neuromuscular weakness, morbid obesity and suboptimal effort during the testing were excluded from the study. Results: 35 subjects (mean age 13.8 +/- 2.7 yrs.; range 7-18 yrs.) fulfilled the criteria. Measured MVV was significantly lower than calculated MVV (89.9 +/- 26.4 vs.122.4 +/- 34.5 L/min; p

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