Terbutaline Accumulates in Blood and Urine following Daily Therapeutic Inhalation.

Purpose: This study investigated pharmacokinetics of terbutaline after single and seven consecutive days of inhalation in exercising trained men. Methods: Twelve healthy young trained men underwent two pharmacokinetic trials comparing single dose (2 mg) and seven consecutive days (2 mgxd-1) of inhaled terbutaline. After inhalation of terbutaline at each trial, subjects performed 90 min of bike ergometer exercise at 65% of maximal oxygen consumption after which they stayed inactive. Blood and urine samples were collected before and after inhalation of terbutaline. Samples were analyzed by high performance liquid chromatography-tandem mass spectrometry. Results: Maximum serum concentration of terbutaline (Cmax) (6.4 (+/-1.2) vs. 4.9 (+/-1.2) ngxmL-1, P = 0.01) (mean (+/-95% confidence interval)) and area under serum concentration-time curve from 0 to 4 hours after inhalation (AUC0-4) (16 (+/-3) vs. 13 (+/-2) ngxmL-1xh, P

from Sports Medicine via xlomafota13 on Inoreader http://ift.tt/2ieTZN1
via IFTTT