Right Prefrontal Cortex Transcranial Direct Current Stimulation Enhances Multi-Day Savings in Sensorimotor Adaptation

We have previously reported that visuospatial working memory performance and magnitude of activation in the right dorsolateral prefrontal cortex predict the rate of visuomotor adaptation. Recent behavioral studies suggest that sensorimotor savings-or faster relearning upon second exposure to a task-are due to recall of these early, strategic components of adaptation. Here we applied anodal transcranial direct current stimulation to right or left prefrontal cortex or left motor cortex. We found that all groups adapted dart throwing movements while wearing prism lenses at the same rate as subjects receiving sham stimulation on Day 1. On test Day 2, which was conducted a few days later, the right prefrontal and left motor cortex groups adapted faster than the sham group. Moreover, only the right prefrontal group exhibited greater savings-expressed as a greater difference between Day 1 and Day 2 errors-in comparison to sham. These findings support the hypothesis that the right prefrontal cortex contributes to sensorimotor adaptation and savings.

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