Effects of Systemic Introductions of Nanoparticles and Salts of Gold and Silver on the Size of the Nuclei of Hypothalamic Neurons in Male Rats

We studied the effects of course (10 days) intraperitoneal injections of salts of gold and silver and colloid solutions of nanoparticles of these metals on the size (mean value of the cross-sections) of the nuclei of hypothalamic neurocytes localized in the preoptic and arcuate nuclei of immature male albino rats. In animals injected with a solution containing tetrachloroaurate ions, the examined morphometric parameters in both structures significantly exceeded the control values. Injections of gold nanoparticles led to significant decreases in the cross-sections of the neurocyte nuclei; thus, the pattern of the effects of gold depended on its physicochemical form. Injections of both silver salt (AgNO₃) and silver nanoparticles led to drops in the mean values of cross-sections of the nuclei of neurocytes. Therefore, shifts of the studied morphofunctional characteristics of the cells belonging to the hypothalamic nuclei resulting from systemic injections of colloid solutions (nanoparticles) of gold and silver are indicative of suppression of functions of the central link of the hypothalamo-hypophyseal-gonadal system after the influence of these factors.

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