Effects of Vitex doniana leaf extract on aluminium-induced toxicity in male albino Wistar rats

2016-09-19T07-23-42Z
Source: Journal of Applied Biology & Biotechnology
Ojochenemi Ejeh Yakubu, Okwesilieze Fred Nwodo.
ABSTRACT This study was conducted to determine the effect of ethanolic leaves extract of Vitex doniana on the toxicity induced by Aluminum Chloride in male albino Wistar rats. The study was designed to carefully observe the ameliorative effect of the extract on aluminum toxicity. A total of 15 male albino rats were used for the study and toxicity was induced using 100mg/kg body weight (bw) AlCl3. They were grouped into three groups of five rats each; normal control, AlCl3 control and AlCl3 + 100mg Vitex doniana respectively. The normal group was fed with standard rat chow only while the AlCl3 control group was orally administered with 100mg/kg bw AlCl3, and the AlCl3 + V.D group was orally administered with 100mg/kg bw extract following administration of AlCl3. The study was conducted for 7 days after which the effect of the extract was assessed following the animal sacrifice. Oral dose of 100mg/kg bw extract of Vitex doniana did not show any significant change in TBARS level of Liver and testes in the experimental groups while the AST, ALT and ALP levels in AlCl3 control and AlCl3 + 100mg Vitex doniana showed significant decrease (p


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