Detecting epileptiform activity from deeper brain regions in spatially filtered MEG data

It is well known that signals from deep sources, such as mesial temporal epileptic foci, are often barely visible in MEG and EEG (Magneto-/Electro-encephalography) recordings. Here we show in two patients how spatial filtering, using a beamforming technique, can be used to identify epileptiform activity. In these patients, this procedure resulted in detection of hippocampal interictal epileptiform discharges, even though these discharges were poorly discernible by visual inspection of the raw MEG time series.

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