The effect of orthodontic separator and short‐term fixed orthodontic appliance on inflammatory mediators and somatosensory function

Journal of Oral Rehabilitation, Volume 0, Issue ja, -Not available-.


from Rehabilitation via xlomafota13 on Inoreader https://ift.tt/2OZWMiq
via IFTTT

SIRT1 overexpression attenuates offspring metabolic and liver disorders as a result of maternal high‐fat feeding

The Journal of Physiology, EarlyView.


from Physiology via xlomafota13 on Inoreader https://ift.tt/2DfIPX9
via IFTTT

Anticipation of food intake induces phosphorylation switch to regulate basolateral amino acid transporter LAT4 (SLC43A2) function

The Journal of Physiology, Volume 0, Issue ja, -Not available-.


from Physiology via xlomafota13 on Inoreader https://ift.tt/2JvoA8a
via IFTTT

Early Functional Outcomes for Pediatric Patients Diagnosed with Anti-NMDA Receptor Encephalitis during Inpatient Rehabilitation

Objective The aims of the current study were to characterize the demographic and clinical presentation of pediatric patients diagnosed with anti-NMDA receptor encephalitis who require inpatient rehabilitation, to examine early functional outcomes, and to investigate predictors of early recovery. Design A retrospective chart review was conducted for 27 pediatric patients diagnosed with anti-NMDA receptor encephalitis who received intensive inpatient neurorehabilitation. Results On average, patients were 10.6 years of age (range 2-18) at the time of symptom onset. Average time to treatment from symptom onset was 27.2 days (range 5-91). Patients displayed significant improvements between admission and discharge WeeFIM DFQ scores across patients (p<.01 mean weefim total dfq score at admission was and discharge younger age onset seizures number of treatments received associated with worse functional outcomes discharge. time to initiate treatment not found be early outcomes. conclusion pediatric patients diagnosed anti-nmda receptor encephalitis displayed significant gains during inpatient rehabilitation despite persistent deficits suggesting the need for ongoing monitoring intervention. correspondence: robyn a. howarth phd children healthcare atlanta department neuropsychology meridian mark road suite ga phone: fax: email: robyn.howarth author disclosures: none funding: no funding copyright wolters kluwer health inc. all rights reserved.>

from Rehabilitation via xlomafota13 on Inoreader https://ift.tt/2SAZbyk
via IFTTT

The Regulation of Cbf1 by PAS Kinase Is a Pivotal Control Point for Lipogenesis Versus Respiration in Saccharomyces cerevisiae

PAS kinase 1 (Psk1) is a key regulator of respiration in Saccharomyces cerevisiae. Herein the molecular mechanisms of this regulation are explored through the characterization of its substrate, Centromere binding factor 1 (Cbf1). CBF1-deficient yeast displayed a significant decrease in cellular respiration, while PAS kinase-deficient yeast, or yeast harboring a Cbf1 phosphosite mutant (T211A) displayed a significant increase. Transmission electron micrographs showed an increased number of mitochondria in PAS kinase-deficient yeast consistent with the increase in respiration. Although the CBF1-deficient yeast did not appear to have an altered number of mitochondria, a mitochondrial proteomics study revealed significant differences in the mitochondrial composition of CBF1-deficient yeast including altered Atp3 levels, a subunit of the mitochondrial F₁-ATP synthase complex. Both beta-galactosidase reporter assays and western blot analysis confirmed direct transcriptional control of ATP3 by Cbf1. In addition, we confirmed the regulation of yeast lipid genes LAC1 and LAG1 by Cbf1. The human homolog of Cbf1, Upstream transcription factor 1 (USF1), is also known to be involved in lipid biogenesis. Herein, we provide the first evidence for a role of USF1 in respiration since it appeared to complement Cbf1 in vivo as determined by respiration phenotypes. In addition, we confirmed USF1 as a substrate of human PAS kinase (hPASK) in vitro. Combined, our data supports a model in which Cbf1/USF1 functions to partition glucose towards respiration and away from lipid biogenesis, while PAS kinase inhibits respiration in part through the inhibition of Cbf1/USF1.

from Genetics via xlomafota13 on Inoreader https://ift.tt/2AEUrQY
via IFTTT

Broadening the operative field: the extent of surgery beyond the patient`s informed consent (the so-called therapeutic exception)

W artykule omówiono przesłanki tzw. wyjątku terapeutycznego, uregulowanego w art. 35 ustawy z dnia 5 grudnia 1996 r. o zawodach lekarza i lekarza dentysty. Konstrukcja ta pozwala lekarzowi, w trakcie operacji, na zmianę zakresu zabiegu ponad zgodę wyrażoną przez pacjenta. Ponadto poruszono kwestię tzw. zgody antycypacyjnej oraz warunki jej skuteczności oraz wyjaśniono, czy w wypadku realizacji przesłanek wyjątku terapeutycznego lekarz jedynie może dokonać odpowiedniej modyfikacji czynności operacyjnych, czy też jest to jego obowiązek. Wskazano również, że w omawianej sytuacji lekarz nie może powoływać się na tzw. stan wyższej konieczności. Prezentowane treści zostały wzbogacone o przedstawienie konkretnych spraw sądowych i ich rozstrzygnięć.

from Anaesthesiology via xlomafota13 on Inoreader https://ift.tt/2qnoIOm
via IFTTT

Inter-arm differences in blood pressure among subjects with disseminated atherosclerosis scheduled for vascular surgery

Background: The measurement of blood pressure (BP) is routinely performed in perioperative care. The reliability of results is essential for the implementation of treatment ensuring haemodynamic stability. The aim of the present study was to assess the prevalence and basic determinants of inter-arm BP differences among patients with advanced peripheral atherosclerosis undergoing vascular surgical procedures of the lower limbs. Methods: The prospective study was carried out in patients scheduled for elective lower limb vascular surgery. One-time non-invasive BP measurements were performed sequentially on the brachial arteries of both upper extremities before the induction of anaesthesia, maintaining the shortest possible interval between measurements. The systolic blood pressure (SBP), diastolic blood pressure (DBP) and mean arterial pressure (MAP) were recorded. Results: The results of 173 patients (including 123 men aged 67 ± 8 years) were analysed. In 16 (9.3%) patients, an inter-arm difference in BP was already observed during the preoperative examination. SBP and DBP was higher in the right limb in 86 (49.7%) an 80 (46.3%) patients, respectively. Moreover, the medians of inter-arm differences in SBP, DBP and MAP were 9 (IQR 4–17), 5 (IQR 3–10) and 7 mm Hg (IQR 3–12), respectively. An evaluation of the determinants of BP differences related to the presence of additional diseases demonstrated that patients with arterial hypertension were characterised by higher SBP and MAP disproportions (P = 0.04 and P = 0.01). Conclusions: In the population of patients with disseminated atherosclerosis, the inter-arm differences in BP substantially exceed the measurement error limits and are likely to be associated with arterial hypertension. If in doubt about BP disproportions, intraoperative monitoring of BP should be recommended using an invasive method on the limb presenting higher non-invasively measured values.

from Anaesthesiology via xlomafota13 on Inoreader https://ift.tt/2QaqQnU
via IFTTT