Integrated genetic, epigenetic, and gene set enrichment analyses identify NOTCH as a potential mediator for PTSD risk after trauma: Results from two independent African cohorts

Psychophysiology, EarlyView.


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A rare male patient with Fontaine progeroid syndrome caused by p.R217H de novo mutation in SLC25A24

American Journal of Medical Genetics Part A, EarlyView.


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A 23‐year follow‐up of a male with Hajdu‐Cheney syndrome due to NOTCH2 mutation

American Journal of Medical Genetics Part A, EarlyView.


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Determining day‐to‐day human variation in indirect calorimetry using Bayesian decision theory

Experimental Physiology, EarlyView.


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Purinergic modulation of chemosensory drive to breathe from the lateral hypothalamus/perifornical area depends upon sleep‐wake and light‐dark phases

Experimental Physiology, Volume 0, Issue ja, -Not available-.


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A comparison of midazolam and zolpidem as oral premedication in children, a prospective randomized double‐blinded clinical trial

Pediatric Anesthesia, EarlyView.


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New Approaches to Diagnosis and Treatment of Functional Dyspepsia

Abstract

Purpose of Review

The purpose of this article is to review the recent literature and discuss the new approaches to the diagnosis and treatment of functional dyspepsia (FD).

Recent Findings

According to the recent American College of Gastroenterology (ACG) and Canadian Association of Gastroenterology (CAG) guideline for dyspepsia, Helicobacter pylori (H. pylori) eradication is recommended as a first treatment option, and proton pump inhibitors (PPIs), tricyclic antidepressants, and prokinetics are listed as second-line therapy. On the other hand, in the Japanese guideline for FD, PPIs and prokinetics are recommended as the first-line treatment. In Japan, acotiamide, a recently launched prokinetic, showed significant efficacy in several clinical trials performed either in Japan or Europe. Regarding non-pharmacological treatment, recent topics include acupuncture, electrical stimulation, gastric peroral endoscopic myotomy, and meal and lifestyle modification. These treatments have provided significant efficacy, which provides some insights into the main pathophysiology of this disease.

Summary

Although FD is common among functional gastrointestinal disorders, it is not easy to relieve the dyspeptic symptoms of FD patients. Combinations of pharmacological and non-pharmacological treatment options are expected.

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