JPM, Vol. 10, Pages 245: An Overview of the Application of Systems Biology in an Understanding of Chronic Rhinosinusitis (CRS) Development

Alexandros G.Sfakianakis shared this article with you from Inoreader JPM, Vol. 10, Pages 245: An Overview of the Application of Systems Biology in an Understanding of Chronic Rhinosinusitis (CRS) Development Μέσω Journal of Personalized Medicine JPM, Vol. 10, Pages 245: An Overview of the Application of Systems Biology in an Understanding of Chronic Rhinosinusitis (CRS) Development Journal of Personalized Medicine doi: 10.3390/jpm10040245 Authors: Michał Michalik Alfred Samet Agnieszka Dmowska-Koroblewska Adrianna Podbielska-Kubera Małgorzata Waszczuk-Jankowska Wiktoria Struck-Lewicka Michał J. Markuszewski Chronic rhinosinusitis (CRS) is an inflammatory disease of the paranasal sinuses. It is defined as the presence of a minimum of two out of four main symptoms such as hyposmia, facial pain, nasal blockage, and discharge, which last for 8–12 weeks. CRS significantly impairs a patient’s quality of life. It needs special treatment mainly focusing on preventing local infection/inflammation with corticosteroid sprays or improving sinus drainage using nasal saline irrigation. When other treatments fail, endoscopic sinus surgery is considered an effective option. According to the state-of-the-art knowledge of CRS, there is more evidence suggesting that it is more of an inflammatory disease than an infectious one. This condition is also treated as a multifactorial inflammatory disorder as it may be triggered by various factors, such as bacterial or fungal infections, airborne irritants, defects in innate immunity, or the presence of concomitant diseases. Due to the inc omplete understanding of the pathological processes of CRS, there is a continuous search for new indicators that are directly related to the pathogenesis of this disease—e.g., in the field of systems biology. The studies adopting systems biology search for possible factors responsible for the disease at genetic, transcriptomic, proteomic, and metabolomic levels. The analyses of the changes in the genome, transcriptome, proteome, and metabolome may reveal the dysfunctional pathways of inflammatory regulation and provide a clear insight into the pathogenesis of this disease. Therefore, in the present paper, we have summarized the state-of-the-art knowledge of the application of systems biology in the pathology and development of CRS. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.