Δευτέρα 16 Νοεμβρίου 2020

Isaacs syndrome: the frontier of neurology, psychiatry, immunology and cancer

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A syndrome of continuous muscle-fibre activity

Authors: Isaacs H

Year published: 1961

Number of times cited: 480

Evolution of Isaacs syndrome from case studies that described continuous ectopic activity through to an understanding as a multisystem autoimmune condition

Six decades ago, Dr Hyam Isaacs reported a new clinical syndrome in the Journal of Neurology, Neurosurgery and Psychiatry.1 Isaacs used the term 'syndrome of continuous muscle-fibre activity ' or the more descriptive 'armadillo disease' for the condition which now has become known as Isaacs syndrome or acquired autoimmune neuromyotonia. In his landmark series, Isaacs described a phenotype of progressive muscle stiffness, with widespread fasciculation leading to weakness. A key finding was continuous muscle activity on electromyography, occurring at rest and unaffected by local nerve blockade. The original report also detailed a number of unsuccessful treatment approaches, as well as an astonishing improvement produced by sodium diphenyl...

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