Cancers, Vol. 12, Pages 3331: Cancer Extracellular Matrix Proteins Regulate Tumour Immunity

Alexandros G.Sfakianakis shared this article with you from Inoreader Cancers, Vol. 12, Pages 3331: Cancer Extracellular Matrix Proteins Regulate Tumour Immunity Μέσω Cancers Cancers, Vol. 12, Pages 3331: Cancer Extracellular Matrix Proteins Regulate Tumour Immunity Cancers doi: 10.3390/cancers12113331 Authors: Gordon-Weeks Yuzhalin The extracellular matrix (ECM) plays an increasingly recognised role in the development and progression of cancer. Whilst significant progress has been made in targeting aspects of the tumour microenvironment such as tumour immunity and angiogenesis, there are no therapies that address the cancer ECM. Importantly, immune function relies heavily on the structure, physics and composition of the ECM, indicating that cancer ECM and immunity are mechanistically inseparable. In this review we highlight mechanisms by which the ECM shapes tumour immunity, identifying potential therapeutic targets within the ECM. These data indicate that to fully realise the potential of cancer immunotherapy, the cancer ECM requires simultaneous consideration. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.