MRI-guided vacuum-assisted breast biopsy: experience of a single tertiary referral cancer centre and prospects for the futureAbstract MRI-guided vacuum-assisted breast biopsy (VABB) is used for suspicious breast cancer (BC) lesions which are detectable only with MRI: because the high sensitivity but limited specificity of breast MRI it is a fundamental tool in breast imaging divisions. We analyse our experience of MRI-guided VABB and critically discuss the potentialities of diffusion-weighted imaging...
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EV-Ident: Identifying tumor-specific extracellular vesicles by size fractionation and single-vesicle analysis.: Related ArticlesEV-Ident: Identifying tumor-specific extracellular vesicles by size fractionation and single-vesicle analysis.Anal Chem. 2020 Mar 24;:Authors: Kim D, Woo HK, Lee C, Min Y, Kumar S, Sunkara V, Jo HG, Lee YJ, Kim J, Ha HK, Cho YKAbstract Tumor-derived extracellular vesicles (EVs) have emerged as a promising source of circulating biomarkers for liquid biopsies. However,...
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Acute Lymphoblastic Leukemia Presenting Initially as Spinal Cord Compression: When Chemotherapy Alone Is Enough: Spinal cord compression (SCC) is a rare initial presentation and complication of acute lymphoblastic leukemia (ALL) with nearly all reported cases occurring in the pediatric population. We report a 38-year-old previously healthy man who presented with acute on chronic lower back pain, gait instability, urinary retention, and severe thrombocytopenia. Radiologic examination revealed two...
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Endoscopic Management of a Proximally Migrated Fully Covered SEMS Using the Stent-in-Stent Technique
Endoscopic Management of a Proximally Migrated Fully Covered SEMS Using the Stent-in-Stent Technique: Endoscopic biliary decompression via stent placement is an important approach for the palliative management of distal malignant biliary obstruction. However, migration of the inserted stent can occur, either distally or proximally; proximal migration is less common, but it also presents a greater challenge for endoscopic resolution. We present a case of a 67-year-old woman who had locally advanced...
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1.Int J Cancer. 2020 Mar 24. doi: 10.1002/ijc.32990. [Epub ahead of print]Metabolic Factors Contribute to T-cell Inhibition in the Ovarian Cancer Ascites.Gong Y1,2, Yang J1,3, Wang Y1,3, Xue L1,2,3,4, Wang J4.Author informationAbstractMalignant ascites is one of the major clinical features of ovarian cancer, which serves as a carrier for the peritoneal dissemination of tumor cells and predicts a poor prognosis in patients. In the microenvironment of ovarian cancer ascites, anti-tumor immunity is...
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1.Indian J Pharmacol. 2020 Jan-Feb;52(1):56-65. doi: 10.4103/ijp.IJP_115_20. Epub 2020 Mar 11.Drug targets for corona virus: A systematic review.Prajapat M1, Sarma P1, Shekhar N1, Avti P2, Sinha S3, Kaur H1, Kumar S1, Bhattacharyya A4, Kumar H1, Bansal S1, Medhi B1.Author informationAbstractThe 2019-novel coronavirus (nCoV) is a major source of disaster in the 21th century. However, the lack of specific drugs to prevent/treat an attack is a major need at this current point of time. In this regard,...
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Telacebec (Q203), a New Antituberculosis Agent: To the Editor: Shortly after the discovery of streptomycin in 1943, it became clear that successful treatment of tuberculosis and prevention of drug resistance required a combination of at least three effective drugs. What followed in the 1950s was the introduction of triple therapy with…
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A phase I study of multi-HLA-binding peptides derived from heat shock protein 70/glypican-3 and a novel combination adjuvant of hLAG-3Ig and Poly-ICLC for patients with metastatic gastrointestinal cancers: YNP01 trial: AbstractBackgroundThis phase I study aimed to evaluate the safety, peptide-specific immune responses, and anti-tumor effects of a novel vaccination therapy comprising multi-HLA-binding heat shock protein (HSP) 70/glypican-3 (GPC3) peptides and a novel adjuvant combination of hLAG-3Ig...
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In vivo anti-MUC1 + tumor activity and sequences of high-affinity anti-MUC1-SEA antibodies: AbstractCleavage of the MUC1 glycoprotein yields two subunits, an extracellular alpha-subunit bound to a smaller transmembrane beta-subunit. Monoclonal antibodies (mAbs) directed against the MUC1 alpha–beta junction comprising the SEA domain, a stable cell-surface moiety, were generated. Sequencing of all seven anti-SEA domain mAbs showed that they clustered into four groups and sequences of all groups are...
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Impact of Silicone Stent Placement in Symptomatic Airway Obstruction due to Non-Small Cell Lung Cancer – A French Multicenter Randomized Controlled Study: The SPOC Trial: Background: Therapeutic bronchoscopy (TB) is an accepted strategy for the symptomatic management of central airway malignant obstruction. Stent insertion is recommended in case of extrinsic compression, but its value in preventing airway re-obstruction after endobronchial treatment without extrinsic compression is unknown. Objective:...
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Mesenchymal neoplasms: Is it time for cytology? New perspectives for the pre-operative diagnosis of soft tissue tumors in the molecular era: Publication date: Available online 25 March 2020Source: Pathology - Research and PracticeAuthor(s): Francesca Pagliuca, Andrea Ronchi, Immacolata Cozzolino, Marco Montella, Federica Zito Marino, Renato FrancoOutlineAbstractKeywords1. THE PRE-OPERATIVE DIAGNOSIS OF SOFT TISSUE TUMORS: LIMITS OF CYTOLOGY FROM A TRADITIONAL POINT OF VIEW2. FEASIBILITY AND ADVANTAGES...
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Neoadjuvant-Adjuvant Pembrolizumab in Resectable Advanced Basal Cell Carcinoma of H&N: Condition: Basal Cell Carcinoma of the Head and NeckInterventions: Drug: Pembrolizumab; Other: Tissue collectionSponsor: Brian GastmanNot yet recruitingNeoadjuvant-Adjuvant Pembrolizumab in Resectable Advanced Basal Cell Carcinoma of H&N The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated...
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Extended Middle Cranial Fossa Approach for Lesions Invading Infratemporal Fossa: Anatomic Study and Clinical Application: Publication date: June 2020Source: World Neurosurgery, Volume 138Author(s): Luciano Mastronardi, Francesco Corrivetti, Carlo Giacobbo Scavo, Guglielmo Cacciotti, Raffaelino Roperto, Albert Sufianov, Luc De Waele, Takanori FukushimaVideo ArticleExtended Middle Cranial Fossa Approach for Lesions Invading Infratemporal Fossa: Anatomic Study and Clinical ApplicationAuthor links open...
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Treatment of a Scalp Arteriovenous Malformation by a Combination of Embolization and Surgical Removal: Publication date: June 2020Source: World Neurosurgery, Volume 138Author(s): Atsushi Kuwano, Isao Naitou, Naoko Miyamoto, Koji Arai, Takakazu KawamataFigures (5)Tables (1)Table 1World NeurosurgeryVolume 138, June 2020, Pages 93-97Case ReportTreatment of a Scalp Arteriovenous Malformation by a Combination of Embolization and Surgical RemovalAuthor links open overlay panelAtsushiKuwano12IsaoNaitou3NaokoMiyamoto3KojiArai12TakakazuKawamata2Show...
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Preexcited Atrial Fibrillation after a Blood Draw: A 33-year-old man presented to the emergency department with palpitations after syncope occurred while a blood sample was being obtained. He had tachycardia, with a heart rate of 192 beats per minute in an irregularly irregular rhythm. An electrocardiogram (Panel A) showed wide-complex tachycardia…
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Postoperative risk stratification in oral squamous cell carcinoma: Publication date: Available online 25 March 2020Source: British Journal of Oral and Maxillofacial SurgeryAuthor(s): J.D. McMahon, R. Pitts, J. Isbister, B. Aslam-Pervez, A. James, D. McLellan, S. Wright, C.J. Wales, J. McCaul, E. Thomson, M.J. Ansell, W.S. Hislop, C. MacIver, J.C. Devine, E. CarsonPostoperative risk stratification in oral squamous cell carcinomaAuthor links open overlay panelJ.D.McMahonaR.PittsbJ.IsbistercB.Aslam-PervezdA.JameseD.McLellanaS.WrightaC.J.WalesaJ.McCaulaE.ThomsonfM.J.AnsellaW.S.HislopgC.MacIverhJ.C.DevinehE.CarsonaaQueen...
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Effect of 5-μg Dose of Dexmedetomidine in Combination With Intrathecal Bupivacaine on Spinal Anesthesia: A Systematic Review and Meta-analysis: Publication date: Available online 25 March 2020Source: Clinical TherapeuticsAuthor(s): Shuyan Liu, Peng Zhao, Yunfeng Cui, Chang Lu, Mingxin Ji, Wenhua Liu, Wei Jiang, Zhuo Zhu, Qianchuang SunAbstractPurposeIntrathecal dexmedetomidine (DEX) has been used to improve the quality and duration of spinal anesthesia. The aim of this meta-analysis is to evaluate...
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Imaging Features of Mucopolysaccharidoses in The Head and Neck: Publication date: Available online 26 March 2020Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Manal Nicolas-JilwanFigures (8)
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Masson's Tumor of the Hand: An Uncommon Histopathological Entity: Masson's tumor or Masson's hemangioma, more precisely termed intravascular papillary endothelial hyperplasia (IPEH), is an uncommon benign vascular lesion of the skin and subcutaneous tissues which can be frequently confused with angiosarcoma. Although relatively rare, its accurate diagnosis is essential since it can clinically be similar to both benign and malignant lesions. We present a 39-year-old man with a round bulging arising...
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Powering the Gracilis for Facial Reanimation: This systematic review with meta-analysis examines the association of outcomes in adults undergoing primary gracilis transfer for facial paralysis with the donor nerve used for neurotization.
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Fluctuant Facial Mass: A woman in her 60s presented with a palpable soft mass in the left cheek and was subsequently diagnosed with a facial varix, which was resected via a novel transoral endoscopic approach.Format: AbstractSend toAnn Plast Surg. 1988 Aug;21(2):155-7.Varix of the facial vein.Manstein ME1, Foote J, Manstein CH, Manstein G.Author information1Division of Plastic Surgery, Albert Einstein Medical Center, Philadelphia, PA 19141.AbstractThe differential diagnosis for a mass overlying the...
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Unilateral Vocal Fold Immobility—More Common Than We Think?: To the Editor We thank Campbell et al for their study analyzing the association of potential clinical factors with the development of unilateral vocal fold immobility (UVFI) following prolonged (>12 hours) mechanical ventilation. In their study, they report a UVFI incidence rate of 7% and established an association between inpatient hypotension, preadmission vascular disease, coronary artery disease, and use of vasopressors with development...
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"Coat Hanger" Appearance of the Ribs: Respiratory distress developed in a male neonate with a giant omphalocele who had been born at 28 weeks of gestation. A "coat hanger" appearance of the ribs was seen on chest radiography.Faeq Al-Mudares, M.D.Texas Children's Hospital, Houston, TXfaeq.al-mudares@bcm.eduCaraciolo J. Fernandes, M.D.Baylor College of Medicine, Houston, TX
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Kaempferol ameliorates Cisplatin induced nephrotoxicity by modulating oxidative stress, inflammation and apoptosis via ERK and NF-κB pathways: Anticancer drug like Cisplatin are associated with serious problem like nephrotoxicity. The effect of Kaempferol is a plant-derived flavonoid compound. The present work evaluated the effect of Kaempferol in mo...
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Blood supply to the caudate lobe of the liver from the right inferior phrenic artery: observation by cone-beam computed tomography during arteriography: AbstractPurposeTo retrospectively evaluate blood supply to the caudate lobe of the liver from the right inferior phrenic artery (RIPA) using cone-beam computed tomography during arteriography (CBCTA-RIPA).MethodsCBCTA-RIPA examinations during transarterial chemoembolization (TACE) for hepatocellular carcinoma (HCC) were collected from 2448 procedures...
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Continuous intraoperative neuromonitoring (cIONM) in head and neck surgery—a review: AbstractAlthough the history of intraoperative neuromonitoring (IONM) dates back to the 19th century, the method did not evolve further than the mere differentiation of nerves until recently. Only the development of continuous IONM (cIONM) has allowed for non-stop analysis of excitation amplitude and latency during surgical procedures, which is nowadays integrated into the software of almost all commercially available...
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Posturale Regulation und Stabilität unter akustischem Input bei Normalhörenden: ZusammenfassungHintergrundDie Haltungsregulierung basiert auf komplexen Interaktionenmechanismen posturaler Subsysteme. Dabei scheint auch das Hören einen Einfluss auf die posturale Kontrolle auszuüben.FragestellungZiel der Arbeit war es, den Einfluss auditorischen Inputs auf die posturale Stabilität zu erfassen und unter Berücksichtigung subjektiver Aspekte Erkenntnisse über Interaktionsmechanismen zwischen auditorischem...
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Vasoactive Intestinal Peptide Stimulates Bone Marrow-Mesenchymal Stem Cells Osteogenesis Differentiation by Activating Wnt/β-Catenin Signaling Pathway and Promotes Rat Skull Defect Repair: Stem Cells and Development, Ahead of Print.
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Screening Children with a Family History of Central Congenital Hypoventilation Syndrome: Congenital central hypoventilation syndrome (CCHS) is a rare genetic disorder of an autonomic nervous disorder that affects breathing. It is characterized by respiratory insufficiency secondary to insensitivity to hypoxemia and hypercarbia, particularly during sleep leading to persistent apnea. We report four individuals across two generations harboring heterozygous 25 polyalanine repeats mutations (PARMs) in...
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Prognostic impact of elevated lactate levels on mortality in critically ill patients with and without preadmission metformin treatment: a Danish registry-based cohort study: Lactate is a robust prognostic marker for the outcome of critically ill patients. Several small studies reported that metformin users have higher lactate levels at ICU admission without a concomitant increase ...
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A Phase 3 Trial of Luspatercept in Patients with Transfusion-Dependent β-Thalassemia: The β-thalassemias are a group of inherited hemoglobin disorders that represent a substantial global health burden. Defective production of β-globin chains of adult hemoglobin causes an imbalanced ratio of α-globin to β-globin. Genetic mutations and secondary modifiers that affect this imbalance…
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Fostemsavir in Adults with Multidrug-Resistant HIV-1 Infection: Among some patients with human immunodeficiency virus type 1 (HIV-1) infection who have undergone multiple antiretroviral therapies, options are limited for future treatment owing to multidrug resistance, contraindications to or unacceptable side effects with various drugs, or other safety…
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Whole brain radiation therapy plus focal boost may be a suitable strategy for brain metastases in SCLC patients: a multi-center study: The treatment for brain metastases in small cell lung cancer (SCLC) is still controversial. The purpose of this study was to compare different brain radiotherapy treatments on SCLC patients with brain metastases.
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Cancers, Vol. 12, Pages 792: Analysis of HPV-Positive and HPV-Negative Head and Neck Squamous Cell Carcinomas and Paired Normal Mucosae Reveals Cyclin D1 Deregulation and Compensatory Effect of Cyclin D2: Cancers, Vol. 12, Pages 792: Analysis of HPV-Positive and HPV-Negative Head and Neck Squamous Cell Carcinomas and Paired Normal Mucosae Reveals Cyclin D1 Deregulation and Compensatory Effect of Cyclin D2Cancers doi: 10.3390/cancers12040792Authors: Jiří Novotný Veronika Bandúrová Hynek Strnad...
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Cancers, Vol. 12, Pages 799: Ionizing Radiation and Complex DNA Damage: Quantifying the Radiobiological Damage Using Monte Carlo Simulations: Cancers, Vol. 12, Pages 799: Ionizing Radiation and Complex DNA Damage: Quantifying the Radiobiological Damage Using Monte Carlo SimulationsCancers doi: 10.3390/cancers12040799Authors: Konstantinos P. Chatzipapas Panagiotis Papadimitroulas Dimitris Emfietzoglou Spyridon A. Kalospyros Megumi Hada Alexandros G. Georgakilas George C. Kagadis...
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A new approach at diabetic foot treatment: phosphodiesterase 5 inhibitors: Publication date: Available online 25 March 2020Source: Medical HypothesesAuthor(s): Muhammet Serdar Buğday, Ersoy Öksüz
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Hyperglycemia and the novel Covid-19 infection: possible pathophysiologic mechanisms: Publication date: Available online 26 March 2020Source: Medical HypothesesAuthor(s): Ioannis Ilias, Lina Zabuliene
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First-line pembrolizumab in advanced non–small cell lung cancer patients with poor performance status: Publication date: May 2020Source: European Journal of Cancer, Volume 130Author(s): Francesco Facchinetti, Giulia Mazzaschi, Fausto Barbieri, Francesco Passiglia, Francesca Mazzoni, Rossana Berardi, Claudia Proto, Fabiana Letizia Cecere, Sara Pilotto, Vieri Scotti, Sabrina Rossi, Alessandro Del Conte, Emanuele Vita, Chiara Bennati, Andrea Ardizzoni, Giulio Cerea, Maria Rita Migliorino, Elisa Sala,...
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Effect of 4-phenylbutyrate and valproate on dominant mutations of WFS1 gene in Wolfram syndrome: AbstractPurposeWolfram syndrome (WS) is a rare disorder caused by mutations in WFS1 that is characterized by diabetes mellitus, optic atrophy, sensorineural deafness, diabetes insipidus, and neurodegeneration. This disease is usually inherited as an autosomal recessive trait, but an autosomal dominant form has been reported. WFS1 encodes a transmembrane protein, which is a maintenance component of endoplasmic...
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Immunocyte density in parathyroid carcinoma is correlated with disease relapse: AbstractPurposeParathyroid carcinoma (PC) is an endocrine malignancy with a poor prognosis. The tumour immune microenvironment is a critical factor influencing the outcomes of multiple cancer types. However, knowledge of the immune microenvironment in PC remains limited.MethodsThe intratumoural density of immunocytes and the Ki-67 index were evaluated immunohistochemically in 51 PC patient samples and were compared with...
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Effects of oral contraceptives on thyroid function and vice versa: AbstractBackgroundThyroid gland dysfunction represents an epidemiologically relevant disease in the female gender, where treatment with oral contraceptives (OCs) is frequently prescribed. Although OCs are able to impact the thyroid gland function, scanty data have been released on this matter so far.AimThe aim of this article was to review how hormonal OCs, including estrogen- or progesterone-only containing medications, interact...
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Comparison of outcomes between patients with de‐novo sinonasal squamous cell carcinoma vs malignant transformations from inverted papillomas: BackgroundThe survival difference between de‐novo sinonasal squamous cell carcinoma (DN‐SNSCC) and SCC arising from inverted papillomas (IPs) is unclear. The purpose of this study was to compare the outcomes between DN‐SNSCC and IP‐transformed SNSCC (IP‐SNSCC) patients.MethodsIn this retrospective review, we compared IP‐SNSCC and DN‐SNSCC cases from the Eye...
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Microfluidic Device Simulates Blinking to Study Eye Drugs: Drugs that are used to treat conditions of the eyes, or ones that simply use the eyes as a route into the rest of the body, can be very difficult to test in pre-clinical trials. Rabbits are often utilized for this, as they lack tear ducts and so don't blink very often, allowing substances to penetrate the eye without being washed away first. But humans blink all the time, and our blinking is more complex, has greater consequences, and is...
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Pandemic Drone to Detect People with Respiratory Conditions: Researchers at the University of South Australia are working to develop a drone that can spot people with potential respiratory infections, remotely. A wall-mounted AI device that listens for coughing and sneezing to predict and monitor pandemics was recently reported in Medgadget, but this latest monitoring device is mobile. The developers say the drone technology could be useful in monitoring and controlling the spread of pandemics, such...
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Associations between Aquaglyceroporin Gene Polymorphisms and Risk of Stroke among Patients with Hypertension: Background. Dysregulations of AQP7 and AQP9 were found to be related to lipid metabolism abnormality, which had been proven to be one of the mechanisms of stroke. However, limited epidemiological studies explore the associations between AQP7 and AQP9 and the risk of stroke among patients with hypertension in China. Aims. We aimed to investigate the associations between genetic variants in...
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Oral Appliances for Snoring and Obstructive Sleep Apnea: Obstructive sleep apnea is a common condition, caused primarily by narrowing of the nasal and pharyngeal airway, leading to partial or complete airway collapse during sleep. Treatment with positive airway pressure (PAP) is considered first-line therapy, due to an efficacy rate of approximately 95%, yet long-term compliance with PAP is less than 40%. The efficacy of a sleep oral appliance is lower than PAP, yet it may have similar effectiveness....
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An unusual presentation of supernumerary teeth in the mastoid bone: The presence of supernumerary teeth in the mastoid bone is rare. We present a patient in whom the abnormal teeth were distant from the jaw and could have been easily misdiagnosed.
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Study of fixation of a mandibular plate for favourable fractures of the mandibular angle: numerical predictions: Fractures of the mandibular angle have been well-described and, in most societies, their incidence is decreasing. In this study we analysed the stabilisation of fractures using a single plate (standard or optimised model). The finite element model was developed based on a mandibular computed tomographic scan, together with a miniplate from DePuy Synthes and an optimised plate. Using the...
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Use of the sublingual gland for reconstruction of a defect in the floor of the mouth after resection of early stage carcinoma: Early stage carcinoma of the floor of the mouth (cT1N0M0) requires extended resection. Skin grafting is a common method of repair, but has many disadvantages. To overcome such shortcomings, we report a technique using the sublingual gland for reconstruction.
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Cerebral white matter microstructural changes in isolated maxillofacial trauma and associated neuropsychological outcomes: Isolated traumatic maxillofacial injury without concomitant brain injury may cause delayed post-concussive symptoms. Early identification allows optimal diagnosis, prognostication, and therapeutic intervention. The aim of this prospective observational study was to investigate longitudinal microstructural changes of the white matter (WM) tracts based on diffusion tensor imaging...
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Low Frequency of Mutation Testing in the United States: An Analysis of 3866 GIST PatientsObjective: The objective of this study was to determine whether there were survival differences associated with KIT mutation testing, type of KIT mutations, and other clinical variables in patients with localized or metastatic gastrointestinal tumor (GIST). Methods: Adult patients with GIST were extracted from the Surveillance Epidemiology and End Results (SEER) database from 2010 to 2015 with follow-up through...
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FDA Approval Summary: Ado-trastuzumab emtansine for the adjuvant treatment of HER2-positive early breast cancer: On May 3, 2019, the FDA granted regular approval to ado-trastuzumab emtansine (KADCYLA), for the adjuvant treatment of patients with human epidermal growth factor receptor 2 (HER2)-positive early breast cancer (EBC) who have residual invasive disease after neoadjuvant taxane based chemotherapy and trastuzumab-based treatment. Approval was based on data from the KATHERINE trial, which randomized...
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Resistance to First-Line Osimertinib in EGFR-mutant NSCLC: Tissue is the Issue: Matched pre-/post-treatment tissue biopsies from EGFR-mutant NSCLC patients demonstrate that histologic transformations, including both SCLC and squamous transformation, are unexpectedly common among patients progressing on first-line osimertinib. The study highlights the key role of tissue testing and underscores the need for innovative therapeutic approaches to prevent, rather than treat, resistance.
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Children with reported penicillin allergy: Public health impact and safety of delabeling: To review the relevant literature related to children with reported penicillin allergy and highlight the different ways in which children could be delabeled and to evaluate the public health impact that a penicillin allergy has for children.
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Our evolving understanding of the pathogenesis and presentations of chronic rhinosinusitis: Until recently, chronic rhinosinusitis (CRS) was viewed as a chronic infectious disease of the sinuses caused by anaerobic bacteria. This dogma led to the concept that, as with any abscess in a closed space, the primary modalities of treatment should be surgical drainage and antibiotics. Not surprisingly, few patients responded favorably. Recent years have seen a revolution in our thinking, with the recognition...
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We continue to fail black children with asthma and allergic disease: Black children have higher prevalence of asthma and increased rates of asthma morbidity and mortality than white children, which has been documented for decades, and this disparity remains persistent.1 In this issue of the Annals of Allergy, Asthma & Immunology, Sitarik et al2 describe their study that determined whether disparities associated with asthma and allergy observed between black and white children at the age of 2...
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Reliability of CT Angiography in Cerebral Vasospasm: A Systematic Review of the Literature and an Inter- and Intraobserver Study [ADULT BRAIN]: BACKGROUND AND PURPOSE:Computed tomography angiography offers a non-invasive alternative to DSA for the assessment of cerebral vasospasm following subarachnoid hemorrhage but there is limited evidence regarding its reliability. Our aim was to perform a systematic review (Part I) and to assess (Part II) the inter- and intraobserver reliability of CTA in the...
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Hippocampal Sclerosis Detection with NeuroQuant Compared with Neuroradiologists [ADULT BRAIN]: BACKGROUND AND PURPOSE:NeuroQuant is an FDA-approved software that performs automated MR imaging quantitative volumetric analysis. This study aimed to compare the accuracy of NeuroQuant analysis with visual MR imaging analysis by neuroradiologists with expertise in epilepsy in identifying hippocampal sclerosis.MATERIALS AND METHODS:We reviewed 144 adult patients who underwent presurgical evaluation for...
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Identification of novel biomarkers, MUC5AC , MUC1 , KRT7 , GAPDH , CD44 for gastric cancer: AbstractGastric cancer (GC) is one of the most common malignant tumors in the world, and it is also the third largest cause of cancer-related death in the world. As far as we know, no biomarker has been widely accepted for early diagnosis and prognosis prediction of gastric cancer. The purpose of this study is to find potential biomarkers to predict the prognosis of GC. The gene expression profiles of GSE2685...
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RFA of primary and metastatic lung tumors: long-term results: AbstractThe aim of our study is a retrospective evaluation of effectiveness and safety of Computed Tomography (CT)-guided radiofrequency ablation (RFA) therapy of primary and metastatic lung lesions in patients that cannot be considered surgical candidates. From February 2007 to September 2017, we performed 264 CT-guided ablation sessions on 264 lesions in 174 patients (112 M and 62 F; mean age, 68 years; range 36–83 years) affected by...
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Multi-perspective clustering of obstructive sleep apnea towards precision therapeutic decision including craniofacial intervention: AbstractPurposePrevious studies focusing on phenotyping obstructive sleep apnea (OSA) have outlined its heterogeneity in clinical symptoms, comorbidities, and polysomnographic features. However, the role of anatomical or pathophysiological causality including craniofacial skeletal deformity has not been studied. We aimed to identify and characterize phenotypes of OSA...
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Response to Tom et al. Comparison of Traditional and Skin-Sparing Approaches for Surgical Treatment of Necrotizing Soft-Tissue Infections (DOI: 10.1089/sur.2019.263)Surgical Infections, Ahead of Print.Surgical InfectionsThu Mar 26, 2020 09:00Antimicrobial Stewardship Reduces Surgical Site Infection Rate, as well as Number and Severity of Pancreatic Fistulae after PancreatoduodenectomySurgical Infections, Volume 21, Issue 3, Page 212-217, April 2020.Surgical InfectionsThu Mar 19, 2020 09:00Awareness...
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Prospects for Redifferentiating Agents in the Use of Radioactive Iodine Therapy for Thyroid Cancer: Thyroid, Ahead of Print.
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Incidence and Mortality of Myocardial Infarction and Stroke in Patients with Hyperthyroidism: A Nationwide Cohort Study in Korea: Thyroid, Ahead of Print. AbstractBackground: Hyperthyroidism is associated with various cardiovascular risk factors. However, the relationship between hyperthyroidism and myocardial infarction (MI) or stroke has not been fully elucidated; only a few studies have investigated the association of hyperthyroidism with survival after MI or stroke.Methods: We included 59,021...
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Complement Activation in Association with Markers of Neutrophil Extracellular Traps and Acute Myocardial Infarction in Stable Coronary Artery Disease: Complement activation and neutrophil extracellular traps (NETs) have both been suggested to drive atherosclerotic plaque progression. Although experimental studies suggest interplay between these two innate immunity components, the relevance in patients with coronary artery disease (CAD) is unclear. The aim of this study was to assess associations...
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Pitanguy Ligamentous Flap: A New Method to Prevent Supratip Deformity in Rhinoplasty: Background: A supratip deformity (SD) is an iatrogenic convexity that occurs in the cephalic region of the nasal tip. SD is still a major problem after rhinoplasty surgery. Objectives: With the method we have described a ligamentous flap was used to create a supratip transition, with adjustable sharpness, while the refinements of the tip rotation and definition were ensured. The aim of the study is to present...
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The Role of Staged Cryosurgery and Three-Dimensional Computed Tomography Integrated Navigation System in the Surgical Management of Severe Involvement of Craniofacial Polyostotic Fibrous Dysplasia: Fibrous dysplasia (FD) is a developmental bone disorder caused by the hamartamatous proliferation of bone-forming cells. A 29-year-old male patient with diagnosis of FD was admitted to our clinic with the symptoms of severe craniomaxillofacial involvement of FD beginning from last year. Neurological examination...
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Hyoid Bone Position and Head Posture in Patients With Richieri-Costa Pereira Syndrome (EIF4A3 Mutations): Robin sequence with cleft mandible and limb anomalies, known as Richieri-Costa-Pereira syndrome (RCPS), is an autosomal recessive acrofacial dysostosis characterized by mandibular cleft and other craniofacial anomalies and respiratory complications. The aim of this cross-sectional study was to describe the hyoid and head posture of 9 individuals with RCPS using cephalometric measurements and...
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Efficacy of Low Mandible Maneuver on Mutational Falsetto: Objectives: Mutational falsetto (MF) is a functional voice disorder involving failure to transition from the high-pitched voice of childhood to the lower-pitched voice of adolescence and adulthood. The low mandible maneuver (LMM) is used by professional singers to relax the larynx and expand the resonance space. It relaxes suprahyoid muscles and pushes the larynx backwards, so it can be used as a therapy for MF. Material and Methods: The data...
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Pathological manifestation of the induced pluripotent stem cell‐derived cortical neurons from an early‐onset Alzheimer's disease patient carrying a presenilin‐1 mutation (S170F)Abstract Objectives Alzheimer's disease (AD) is the most common neurodegenerative disease which is characterized by the formation of amyloid beta (Aβ) plaques and neurofibrillary tangles. These abnormal proteins induce disturbance in mitochondrial dynamics and defect in autophagy system. Since presenilin‐1 (PS1) is a core...
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Smartphones and Text Messaging are Associated With Higher Parent Quality of Life Scores and Enrollment in Early Intervention After NICU Discharge.Related ArticlesSmartphones and Text Messaging are Associated With Higher Parent Quality of Life Scores and Enrollment in Early Intervention After NICU Discharge. Clin Pediatr (Phila). 2019 07;58(8):903-911 Authors: Flores-Fenlon N, Song AY, Yeh A, Gateau K, Vanderbilt DL, Kipke M, Friedlich P, Lakshmanan A Abstract The purpose of this study was to evaluate...
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Pelvic Floor Muscle Training for Older Women with Urinary IncontinenceAbstract Purpose of Review To review and discuss the efficacy of pelvic floor muscle training (PFMT) for urinary incontinence (UI) in older women. Recent Findings As opposed to UI in young and middle-aged women, UI in older women is often multifactorial. One randomized control trial (RCT) and secondary analyses from four RCTs suggest that healthy older women...Latest Results for Current Geriatrics Reports18hMark above section as...
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Symptomatic scalp fistula present in a 14-month-old toddlerThis case report covers the resection of a pulsatile scalp fistula, in a 14-month-old toddler. We discuss the patient diagnosis, imaging techniques used, as well as the patient's surgical intervention. We highlight the aetiology of arteriovenous fistulas, while comparing and contrasting previous case reports and their interventions, to our own specific case.BMJ Case Reports Last 6 Issues5mIatrogenic post-pulpectomy cervicofacial subcutaneous...
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Risk assessment of obstructive sleep apnea among gastroesophageal reflux disease patients in Taif, Saudi Arabia: Muhannad M Alharthi, Meshari H Altowairqi, Sultan S Alamri, Hosam T Mashrah, Mazen A Almalki, Eidha Fawzan Eidha AljuaidJournal of Family Medicine and Primary Care 2020 9(3):1633-1639Background: Previous studies have reported the association between gastroesophageal reflux disease (GERD) and obstructive sleep apnea (OSA). Objectives: The aim of the present study was to assess the prevalence...
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Long-term impacts of tonsillectomy on children's immune functions: Masoud Radman, Asiyeh Ferdousi, Hossein Khorramdelazad, Pooneh JalaliJournal of Family Medicine and Primary Care 2020 9(3):1483-1487Background: There exist a wide level of discrepancy regarding the role of tonsils and its indication among pediatricians and ENT specialists. This fact sometimes causes confusion and delay in making the right decisions by parents and specialists for appropriate treatment of patients. Objectives: Thus,...
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Patient handling in India—Evidence from a pilot studyNidhin Koshy, Sheetal Sriraman, Yogeesh D KamatJournal of Family Medicine and Primary Care 2020 9(3):1397-1402 Background: Manual handling forms an important part of a health care worker's daily routine. Faulty techniques may result in musculoskeletal injuries in health workers and further injury to patients. Objectives: In our study, we assessed the techniques of patient moving and handling by health care workers in our hospital. Our aim was to...
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"Lessons from the extremes: Epigenetic and genetic regulation in point monocentromere and holocentromere establishment on artificial chromosomes"Publication date: Available online 26 March 2020Source: Experimental Cell ResearchAuthor(s): Charmaine Yan Yu Wong, Yick Hin Ling, Jason Ka Ho Mak, Jing Zhu, Karen Wing Yee YuenExperimental Cell Research15hMark above section as read AntibioticsAntibiotics, Vol. 9, Pages 141: Single Blinded Study on the Feasibility of Decontaminating LA-MRSA in Pig Compartments...
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Influence of Geometry and Architecture on the In Vivo Success of 3D-Printed Scaffolds for Spinal FusionTissue Engineering Part A, Ahead of Print.Tissue Engineering Part A - Table of Contents13hMark above section as read CosmeticsCosmetics, Vol. 7, Pages 20: Powder Coating for Healthcare Aluminum PackagingCosmetics, Vol. 7, Pages 20: Powder Coating for Healthcare Aluminum Packaging Cosmetics doi: 10.3390/cosmetics7020020 Authors: Stefano Rossi Massimo Calovi Matteo Tonelli Restrictive regulations...
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Cancers, Vol. 12, Pages 800: A Nine-Gene Signature for Predicting the Response to Preoperative Chemoradiotherapy in Patients with Locally Advanced Rectal CancerCancers, Vol. 12, Pages 800: A Nine-Gene Signature for Predicting the Response to Preoperative Chemoradiotherapy in Patients with Locally Advanced Rectal Cancer Cancers doi: 10.3390/cancers12040800 Authors: In Ja Park Yun Suk Yu Bilal Mustafa Jin Young Park Yong Bae Seo Gun-Do Kim Jinpyo Kim Chang Min Kim Hyun Deok Noh Seung-Mo Hong Yeon Wook...
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Evaluation of Spodick's Sign and Other Electrocardiographic Findings as Indicators of STEMI and Pericarditis: Publication date: Available online 25 March 2020Source: The Journal of Emergency MedicineAuthor(s): Michael D. Witting, Kami M. Hu, Aaron A. Westreich, Semhar Tewelde, Ali Farzad, Amal Mattu
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Alkyl Thiourea Functionalised Silica for the Effective Removal of Heavy Metals from Acanthopanax senticosus ExtractAcanthopanax senticosus extract with excessive standard of Pb, Cd, Hg, and Cu was used as the research object, and the alkyl thiourea functionalised silica was used as a new heavy metal removal scavenger. The heavy metal removal process was optimised by orthogonal experiment with dynamic and static adsorption modes. Meanwhile, the content of Acanthopanax B and Acanthopanax E, the solid...
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Numerical Simulation and Experimental Study on Flow of Polymer Aqueous Solution in Porous Jet NozzleThe addition of a polymer to the jet medium enhances its ability to break rock, and the structure of the nozzle plays a vital role in the full utilization of energy. In this paper, a self-propelled porous jet bit with a support plate is designed, which can prevent the drill bit from jamming due to the jet nozzle against the bottom of the well during the drilling process. And the structural design of...
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Covid-19: medical schools given powers to graduate final year students early to help NHSMedical schools have been granted the power to graduate their students early to allow them to work for the NHS during the covid-19 pandemic, the BMA has said.1 This follows the surprise statement...Latest headlines from BMJ19hCovid-19: What is the UK's testing strategy?What tests are currently available in the UK?The NHS is using polymerase chain reaction (PCR) testing to determine which people currently have...
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A Message from the Front Lines of the PandemicI don't want talk. I don't want assurances. I want action. I want boxes of N95 masks and other safety gear piling up in hospitals -- Read more on ScientificAmerican.comScientific American Blog Posts14hFeast Your Eyes on Australia's Newly Explored Depths [Video]Take a few moments to enjoy stalked barnacles, googly-eyed glass squid and other oddities of the deep, where it is cold, dark and 100 percent coronavirus free -- Read more on ScientificAmerican.comScientific...
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Thiotepa hyperpigmentation preceding epidermal necrosis: malignant intertrigo misdiagnosed as Stevens-Johnson syndrome-toxic epidermal necrolysis overlapThiotepa is a common alkylating agent known to precipitate cutaneous reactions consistent with toxic erythema of chemotherapy, including erythema and hyperpigmentation. Herein, we describe an atypical case of malignant intertrigo involving preferential erythema and desquamation not only of skin folds but also of occluded areas after thiotepa-based...
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The Wedding with a Stolen Goddess: The Ethnography of a Cult in Rural Tamil NaduAbstract The paper provides a critical overview of the perspective that stratifies society in India into a series of different classes, resulting in the mobility of particular castes or social groups. For this purpose, the study presents ethnographic material concerning the foundation and development of a non-Brahman temple in the Tamil low-caste settlement of Line Kollai, which is in a neighbourhood close to the city...
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Water, Vol. 12, Pages 938: Optimizing the Management Strategies of a Multi-Purpose Multi-Reservoir System in VietnamWater, Vol. 12, Pages 938: Optimizing the Management Strategies of a Multi-Purpose Multi-Reservoir System in Vietnam Water doi: 10.3390/w12040938 Authors: Chou Linh Wu Resource shortages are having an increasingly severe impact as global trends like rapid population growth, urbanization, economic development, and climate change unfold. Moreover, rising living standards across many regions...
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Pathogens, Vol. 9, Pages 246: Cold Exposure-Induced Up-Regulation of Hsp70 Positively Regulates PEDV mRNA Synthesis and Protein Expression In VitroPathogens, Vol. 9, Pages 246: Cold Exposure-Induced Up-Regulation of Hsp70 Positively Regulates PEDV mRNA Synthesis and Protein Expression In Vitro Pathogens doi: 10.3390/pathogens9040246 Authors: Kong Xu Ran Yin Feng Sun Porcine epidemic diarrhea (PED) is a highly contagious, intestinal infectious disease caused by porcine epidemic diarrhea virus (PEDV)....
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Microorganisms, Vol. 8, Pages 471: Pseudomonas PS01 Isolated from Maize Rhizosphere Alters Root System Architecture and Promotes Plant GrowthMicroorganisms, Vol. 8, Pages 471: Pseudomonas PS01 Isolated from Maize Rhizosphere Alters Root System Architecture and Promotes Plant Growth Microorganisms doi: 10.3390/microorganisms8040471 Authors: Chu Bui Hoang The objectives of this study were to evaluate the plant growth promoting effects on Arabidopsis by Pseudomonas sp. strains associated with rhizosphere...
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International Journal of Molecular SciencesIJMS, Vol. 21, Pages 2309: The Encystment-Related MicroRNAs and Its Regulation Molecular Mechanism in Pseudourostyla cristata Revealed by High Throughput Small RNA SequencingIJMS, Vol. 21, Pages 2309: The Encystment-Related MicroRNAs and Its Regulation Molecular Mechanism in Pseudourostyla cristata Revealed by High Throughput Small RNA Sequencing International Journal of Molecular Sciences doi: 10.3390/ijms21072309 Authors: Nan Pan Muhammad Zeeshan Bhatti...
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International Journal of Environmental Research and Public HealthIJERPH, Vol. 17, Pages 2232: Demoralization and Its Relationship with Depression and Hopelessness in Suicidal Patients Attending an Emergency DepartmentIJERPH, Vol. 17, Pages 2232: Demoralization and Its Relationship with Depression and Hopelessness in Suicidal Patients Attending an Emergency Department International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17072232 Authors: Costanza Baertschi Richard-Lepouriel...
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Cells, Vol. 9, Pages 801: A Regulatory Noncoding RNA, nc886, Suppresses Esophageal Cancer by Inhibiting the AKT Pathway and Cell Cycle ProgressionCells, Vol. 9, Pages 801: A Regulatory Noncoding RNA, nc886, Suppresses Esophageal Cancer by Inhibiting the AKT Pathway and Cell Cycle Progression Cells doi: 10.3390/cells9040801 Authors: Wonkyun Ronny Im Hyun-Sung Lee Yeon-Su Lee Ju-Seog Lee Hee-Jin Jang Seon-Young Kim Jong-Lyul Park Yeontaek Lee Moon Soo Kim Jong Mog Lee In-Hoo Kim Sung Ho Jeon Yong Sun...
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Antibiotics, Vol. 9, Pages 141: Single Blinded Study on the Feasibility of Decontaminating LA-MRSA in Pig Compartments under Routine ConditionsAntibiotics, Vol. 9, Pages 141: Single Blinded Study on the Feasibility of Decontaminating LA-MRSA in Pig Compartments under Routine Conditions Antibiotics doi: 10.3390/antibiotics9040141 Authors: Kobusch Müller Mellmann Köck Boelhauve ： In countries with intensive pig husbandry in stables, the prevalence of livestock-associated (LA) methicillin-resistant...
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