NRF2, p53, and p16: Predictive biomarkers to stratify human papillomavirus associated head and neck cancer patients for de-escalation of cancer therapy.: Related ArticlesNRF2, p53, and p16: Predictive biomarkers to stratify human papillomavirus associated head and neck cancer patients for de-escalation of cancer therapy.Crit Rev Oncol Hematol. 2020 Feb 01;148:102885Authors: Ramesh PS, Devegowda D, Singh A, Thimmulappa RKAbstract Patients with HPV associated (HPV+ve) head and neck squamous...
Quantifying the dose accumulation uncertainty after deformable image registration in head-and-neck radiotherapy.: Related ArticlesQuantifying the dose accumulation uncertainty after deformable image registration in head-and-neck radiotherapy.Radiother Oncol. 2020 Feb 13;:Authors: Lowther NJ, Marsh SH, Louwe RJWAbstract BACKGROUND AND PURPOSE: Deformable image registration (DIR) facilitated dose reconstruction and accumulation can be applied to assess delivered dose and verify the validity...
Castleman disease of the neck: A case report.: Related ArticlesCastleman disease of the neck: A case report.J Pak Med Assoc. 2020 Feb;70(2):354-356Authors: Pasha H, Siddiqui MI, Wasif MAbstract Castleman disease is a rare lymphoproliferative disorder with two distinctive presentations, namely Unicentric disease and Multicentric disease. Unicentric disease occurs as a solitary enlarged mass in the mediastinum and is rarely found in the head and the neck, whereas, Multicentric disease appears...
British Thyroid Association 2014 classification ultrasound scoring of thyroid nodules in predicting malignancy: Diagnostic performance and inter-observer agreement.: Related ArticlesBritish Thyroid Association 2014 classification ultrasound scoring of thyroid nodules in predicting malignancy: Diagnostic performance and inter-observer agreement.Ultrasound. 2020 Feb;28(1):4-13Authors: Weller A, Sharif B, Qarib MH, St Leger D, De Silva HS, Lingam RKAbstract Objectives: To assess the inter-observer...
Pilomatrixoma of the head and neck: Typical presentation of a rare lesion.: Related ArticlesPilomatrixoma of the head and neck: Typical presentation of a rare lesion.Ultrasound. 2020 Feb;28(1):51-53Authors: Sirakaya M, Vydianath SAbstract Pilomatrixomas are benign tumours of primitive hair follicles, usually presenting as painless lumps in the head and neck region in children. As they are uncommon, they are often misdiagnosed clinically. We discuss a case of a five-year-old boy presenting...
Nimotuzumab-cisplatin-radiation versus cisplatin-radiation in HPV negative oropharyngeal cancer.: Related ArticlesNimotuzumab-cisplatin-radiation versus cisplatin-radiation in HPV negative oropharyngeal cancer.Oncotarget. 2020 Jan 28;11(4):399-408Authors: Noronha V, Patil VM, Joshi A, Mahimkar M, Patel U, Pandey MK, Chandrasekharan A, Dsouza H, Bhattacharjee A, Mahajan A, Sabale N, Agarwal JP, Ghosh-Laskar S, Budrukkar A, D'Cruz AK, Chaturvedi P, Pai PS, Chaukar D, Nair S, Thiagarajan S, Banavali...
Colon mass: a rare site of metastasis for squamous cell cancer of the head and neck.: Related ArticlesColon mass: a rare site of metastasis for squamous cell cancer of the head and neck.J Surg Case Rep. 2020 Feb;2020(2):rjz391Authors: Greenberg S, Inman JC, Yung E, Choo EBAbstract A 61-year-old man with a past medical history significant for heavy alcohol consumption and an extensive smoking history presented with a left neck mass which was diagnosed as a pT3N2bM0 squamous cell carcinoma...
Econazole nitrate reversed the resistance of breast cancer cells to Adriamycin through inhibiting the PI3K/AKT signaling pathway.: Related ArticlesEconazole nitrate reversed the resistance of breast cancer cells to Adriamycin through inhibiting the PI3K/AKT signaling pathway.Am J Cancer Res. 2020;10(1):263-274Authors: Dong C, Chen Y, Ma J, Yang R, Li H, Liu R, You D, Luo C, Li H, Yang S, Ke K, Lin MC, Chen CAbstract Activation of the phosphoinositide 3 kinase (PI3K)/AKT pathway is frequently...
Novel drug delivery system based on hollow mesoporous magnetic nanoparticles for head and neck cancers--targeted therapy in vitro and in vivo.: Related ArticlesNovel drug delivery system based on hollow mesoporous magnetic nanoparticles for head and neck cancers--targeted therapy in vitro and in vivo.Am J Cancer Res. 2020;10(1):350-364Authors: Zhang Z, Zhuang L, Lin Y, Yan M, Lv J, Li X, Lin H, Zhu P, Lin Q, Xu YAbstract Magnetic targeting delivery of anti-cancer drug with controlled drug...
Surface Dosimetry of Patients Undergoing Total Body Irradiation: A Retrospective Analysis for Quality Assurance.: Related ArticlesSurface Dosimetry of Patients Undergoing Total Body Irradiation: A Retrospective Analysis for Quality Assurance.Cureus. 2020 Feb 06;12(2):e6900Authors: Sengupta A, Wilke DR, Cherpak A, Chytyk-Praznik K, Schella J, Yewondwossen M, Allan J, Mulroy LAbstract Total body irradiation (TBI) is used prior to bone marrow transplantation as part of the conditioning regimen...
Endotracheal Metastasis Causing Airway Obstruction.: Related ArticlesEndotracheal Metastasis Causing Airway Obstruction.Clin Pract Cases Emerg Med. 2020 Feb;4(1):96-98Authors: Yano Y, Fujiwara T, Mizuta MAbstract Endotracheal metastasis, a critical complication of primary lung cancer, is an extremely rare lesion. A 73-year-old woman who had previously received treatment for lung cancer presented to our emergency department with dyspnea. A chest computed tomography and nasopharyngolaryngoscopy...
Highly accelerated compressed sensing time-of-flight magnetic resonance angiography may be reliable for diagnosing head and neck arterial steno-occlusive disease: a comparative study with digital subtraction angiography.: Related ArticlesHighly accelerated compressed sensing time-of-flight magnetic resonance angiography may be reliable for diagnosing head and neck arterial steno-occlusive disease: a comparative study with digital subtraction angiography.Eur Radiol. 2020 Feb 17;:Authors: Zhang X,...
Sexually Transmitted Infections and Contraceptive Use in AdolescentsPublication date: Available online 17 February 2020Source: American Journal of Preventive MedicineAuthor(s): Karen J. Derefinko, Sydney Ashby, Tristan Hayes, Cameron Kaplan, Zoran Bursac, Francisco I. Salgado García, Amy Madjlesi, Leah Tonkin, Michelle Bowden, Filoteia Popescu, Teresa WatersIntroductionAlthough a number of contraception methods exist, long-acting reversible contraceptives have been recommended for female adolescents...
State of the globe: Human Nipah virus infection needs "One Health"Sunil Kumar RainaJournal of Global Infectious Diseases 2020 12(1):1-2Active case finding in tuberculosis: Need for a cautious approachSunil Kumar RainaJournal of Global Infectious Diseases 2020 12(1):3-4A study of multidrug-resistant, colistin-only-sensitive infections in intubated and mechanically ventilated patients over 2 yearsIpe Jacob, Pradeep Rangappa, Lakshman C Thimmegowda, Karthik RaoJournal of Global Infectious Diseases 2020...
Medical disciplinary jurisprudence in alleged malpractice in radiology: 10-year Dutch experience.: Related ArticlesMedical disciplinary jurisprudence in alleged malpractice in radiology: 10-year Dutch experience.Eur Radiol. 2020 Feb 17;:Authors: Kwee RM, Kwee TCAbstract PURPOSE: To systematically investigate the frequency and types of allegations related to radiology practice handled by the Dutch Medical Disciplinary Court in the past 10 years. METHODS: The Dutch Medical Disciplinary...
Artificial-intelligence-based detection of pharyngeal cancer using convolutional neural networks.: Related ArticlesArtificial-intelligence-based detection of pharyngeal cancer using convolutional neural networks.Dig Endosc. 2020 Feb 16;:Authors: Tamashiro A, Yoshio T, Ishiyama A, Tsuchida T, Hijikata K, Yoshimizu S, Horiuchi Y, Hirasawa T, Seto A, Sasaki T, Fujisaki J, Tada TAbstract OBJECTIVES: The prognosis for pharyngeal cancer is relatively poor. It is usually diagnosed in an advanced...
Two miRNA prognostic signatures of head and neck squamous cell carcinoma: A bioinformatic analysis based on the TCGA dataset.: Related ArticlesTwo miRNA prognostic signatures of head and neck squamous cell carcinoma: A bioinformatic analysis based on the TCGA dataset.Cancer Med. 2020 Feb 17;:Authors: Wu C, Tong L, Wu C, Chen D, Chen J, Li Q, Jia F, Huang ZAbstract MicroRNAs(miRNAs) are maladjusted in multifarious malignant tumor and can be considered as both carcinogens and tumor-inhibiting...
Integrated analysis of different mRNA and miRNA profiles in human hypopharyngeal squamous cell carcinoma sensitive and resistant to chemotherapy.: Integrated analysis of different mRNA and miRNA profiles in human hypopharyngeal squamous cell carcinoma sensitive and resistant to chemotherapy.Neoplasma. 2020 Feb 17;:Authors: Kong F, He S, Shen X, Li L, Fang J, Lian MAbstract The purpose of this study was to identify potential miRNAs and mRNAs involved in chemotherapy insensitivity in hypopharyngeal...
RGMB-AS1/miR-22-3p/NFIB axis contributes to the progression of gastric cancer.: RGMB-AS1/miR-22-3p/NFIB axis contributes to the progression of gastric cancer.Neoplasma. 2020 Feb 17;:Authors: Zhang W, Zhan F, Li D, Wang T, Huang HAbstract Gastric cancer (GC), one of the most common cancers worldwide, presents a considerable threat to human health. Although multiple investigations have been made to figure out therapies for this disease, the prognosis of patients suffered with GC remains poor....
Artificial intelligence in sleep medicine: Background and implications for clinicians.: Artificial intelligence in sleep medicine: Background and implications for clinicians.J Clin Sleep Med. 2020 Feb 17;:Authors: Goldstein CA, Berry RB, Kent DT, Kristo DA, Seixas AA, Redline S, Westover MBAbstract None: Polysomnography (PSG) remains the cornerstone of objective testing in sleep medicine and results in massive amounts of electrophysiological data, which is well-suited for analysis with artificial...
Design of a Biocompatible Drug-Eluting Tracheal Stent in Mice with Laryngotracheal Stenosis.: Design of a Biocompatible Drug-Eluting Tracheal Stent in Mice with Laryngotracheal Stenosis.J Vis Exp. 2020 Jan 21;(155):Authors: Duvvuri M, Motz K, Tsai HW, Lina I, Ding D, Lee A, Hillel ATAbstract Laryngotracheal stenosis (LTS) is a pathologic narrowing of the subglottis and trachea leading to extrathoracic obstruction and significant shortness of breath. LTS results from mucosal injury from a...
Distinct Biomarker Profiles and Clinical Characteristics in T1-T2 Glottic and Supraglottic Carcinomas.: Distinct Biomarker Profiles and Clinical Characteristics in T1-T2 Glottic and Supraglottic Carcinomas.Laryngoscope. 2020 Feb 17;:Authors: Wachters JE, Kop E, Slagter-Menkema L, Mastik M, van der Wal JE, van der Vegt B, de Bock GH, van der Laan BFAM, Schuuring EAbstract BACKGROUND: In early stage laryngeal squamous cell carcinoma (LSCC) radiotherapy with curative intent is a major treatment...
The Relationship Between Cisplatin-related and Age-related Hearing Loss During an Extended Follow-up.: The Relationship Between Cisplatin-related and Age-related Hearing Loss During an Extended Follow-up.Laryngoscope. 2020 Feb 17;:Authors: Skalleberg J, Småstuen MC, Oldenburg J, Osnes T, Fosså SD, Bunne MAbstract OBJECTIVES: Cisplatin-related hearing loss (HL) is claimed to progress after treatment. This controlled longitudinal study with extended follow-up investigates HL in testicular cancer...
Trust as a Predictor of Patient Perceptions Regarding Overlapping Surgery and Trainee Independence.: Trust as a Predictor of Patient Perceptions Regarding Overlapping Surgery and Trainee Independence.Laryngoscope. 2020 Feb 17;:Authors: Langerman A, Brelsford KM, Diehl CJ, Harris CR, Stewart TGAbstract OBJECTIVES: To examine opinions on trainee independence and attending presence among a cross-section of the general population and explore how perceptions of trust, past experiences, and demographics...
High-Risk Cutaneous Squamous Cell Cancer of the Head and Neck: Risk Factors for Recurrence and Impact of Adjuvant Treatment.: High-Risk Cutaneous Squamous Cell Cancer of the Head and Neck: Risk Factors for Recurrence and Impact of Adjuvant Treatment.Laryngoscope. 2020 Feb 17;:Authors: Trosman SJ, Zhu A, Nicolli EA, Leibowitz JM, Sargi ZBAbstract OBJECTIVES: The behavior of advanced cutaneous squamous cell carcinoma of the head and neck (HNcSCC) remains poorly understood, with highly variable...
Melanoma of the External Auditory Canal: A Review of Seven Cases at a Tertiary Care Referral Center.
Melanoma of the External Auditory Canal: A Review of Seven Cases at a Tertiary Care Referral Center.: Melanoma of the External Auditory Canal: A Review of Seven Cases at a Tertiary Care Referral Center.Laryngoscope. 2020 Feb 17;:Authors: Appelbaum EN, Gross ND, Diab A, Bishop AJ, Nader ME, Gidley PWAbstract OBJECTIVES/HYPOTHESIS: Examine the presentation and management characteristics of seven patients with melanoma of the external auditory canal (EAC). STUDY DESIGN: Retrospective...
Cutaneous squamous cell carcinoma in the organ transplant recipient.: Cutaneous squamous cell carcinoma in the organ transplant recipient.Oral Oncol. 2020 Feb 14;103:104562Authors: Bibee K, Swartz A, Sridharan S, Kurten CHL, Wessel CB, Skinner H, Zandberg DPAbstract One in twenty solid organ transplant recipients (SOTRs) will develop a highly morbid or fatal cutaneous carcinoma after transplantation. The majority of these cases develop on the head and neck and may require intervention on...
The relation between dizziness and suspected obstructive sleep apnoea: AbstractPurpose(1) To determine the prevalence of a high risk of obstructive sleep apnoea (OSA) in patients with dizziness. (2) To assess a relation between the risk of OSA and dizziness-related impairment. (3) To determine whether a high risk of OSA is associated with unexplained dizziness or with hyperventilation/anxiety disorders.MethodsIn this cross-sectional study, we included Dutch adult patients with dizziness. Patients...
Superomedial partial arytenoidectomy for voice improvement by correction of posterior glottic insufficiency: AbstractPurposeArytenoid resection is a well-known intervention to improve glottic airway. Superomedial partial arytenoidectomy (SPA) can also be used for voice improvement by correcting posterior glottic insufficiency in patients with an obstructing anteromedially prolapsed arytenoid. Posterior glottic insufficiency can be difficult to address and traditionally involves challenging arytenoid...
Reconsidering the central role of mucins in dry eye and ocular surface diseases.: Related ArticlesReconsidering the central role of mucins in dry eye and ocular surface diseases.Prog Retin Eye Res. 2019 07;71:68-87Authors: Baudouin C, Rolando M, Benitez Del Castillo JM, Messmer EM, Figueiredo FC, Irkec M, Van Setten G, Labetoulle MAbstract Mucins are key actors in tear film quality and tear film stability. Alteration of membrane-bound mucin expression on corneal and conjunctival epithelial...
An international survey about rapid sequence intubation of 10,003 anaesthetists and 16 airway experts.: Related ArticlesAn international survey about rapid sequence intubation of 10,003 anaesthetists and 16 airway experts.Anaesthesia. 2020 03;75(3):313-322Authors: Zdravkovic M, Berger-Estilita J, Sorbello M, Hagberg CAAbstract Pulmonary aspiration of gastric content is a significant cause of anaesthesia-related morbidity and mortality. High-quality prospective randomised evidence to support...
Rare amyloidoma of the tongue base: A case report and review of the literature.: Related ArticlesRare amyloidoma of the tongue base: A case report and review of the literature.Mol Clin Oncol. 2020 Mar;12(3):258-262Authors: Musat G, Evsei A, Calina D, Docea AO, Doukas SG, Vageli DP, Nepka C, Spandidos DA, Mitroi MAbstract Localized amyloidosis is a rare condition characterized by the deposition of misfolding protein in a tissue, without other systemic manifestations. Only a small number of...
Changes to Ventilation, Vocalization, and Thermal Nociception in the Pink1-/- Rat Model of Parkinson's Disease.: Changes to Ventilation, Vocalization, and Thermal Nociception in the Pink1-/- Rat Model of Parkinson's Disease.J Parkinsons Dis. 2020 Feb 13;:Authors: Johnson RA, Kelm-Nelson CA, Ciucci MRAbstract BACKGROUND: Individuals with Parkinson's disease (PD) experience significant vocal communication deficits. Findings in the Pink1-/- rat model of early-onset PD suggest that ultrasonic...
Assessing the Heterogeneity of Complaints Related to Tinnitus and Hyperacusis from an Unsupervised Machine Learning Approach: An Exploratory Study.: Related ArticlesAssessing the Heterogeneity of Complaints Related to Tinnitus and Hyperacusis from an Unsupervised Machine Learning Approach: An Exploratory Study.Audiol Neurootol. 2020 Feb 14;:1-16Authors: Palacios G, Noreña A, Londero AAbstract INTRODUCTION: Subjective tinnitus (ST) and hyperacusis (HA) are common auditory symptoms that may...
Long-term treatment outcomes in children with auditory neuropathy spectrum disorder (ANSD).: Related ArticlesLong-term treatment outcomes in children with auditory neuropathy spectrum disorder (ANSD).Int J Pediatr Otorhinolaryngol. 2020 Feb 07;132:109938Authors: Ehrmann-Müller D, Back D, Kühn H, Hagen R, Shehata-Dieler WAbstract INTRODUCTION: The present article shows long-term results in the hearing and speech development of children with auditory neuropathy spectrum disorder (ANSD). Some...
Preventing recurrent acute otitis media with Streptococcus salivarius 24SMB and Streptococcus oralis 89a five months intermittent treatment: An observational prospective cohort study.: Related ArticlesPreventing recurrent acute otitis media with Streptococcus salivarius 24SMB and Streptococcus oralis 89a five months intermittent treatment: An observational prospective cohort study.Int J Pediatr Otorhinolaryngol. 2020 Feb 05;132:109921Authors: Cantarutti A, Rea F, Donà D, Cantarutti L, Passarella...
How well do we know Gradenigo? A comprehensive literature review and proposal for novel diagnostic categories of Gradenigo's syndrome.: How well do we know Gradenigo? A comprehensive literature review and proposal for novel diagnostic categories of Gradenigo's syndrome.Int J Pediatr Otorhinolaryngol. 2020 Feb 08;132:109942Authors: McLaren J, Cohen MS, El Saleeby CMAbstract Gradenigo's Syndrome is a rare complication of otitis media and/or mastoiditis resulting in inflammation of the petrous...
Congenital midnasal stenosis: Conservative management.: Congenital midnasal stenosis: Conservative management.Int J Pediatr Otorhinolaryngol. 2020 Feb 08;132:109939Authors: Sahin Onder S, Sahin-Yilmaz A, Gergin Tinay O, Unsal BAbstract INTRODUCTION: Congenital midnasal stenosis (MNS) is an extremely rare disease which may be life threatening, and shows difficulty in diagnosis and management. This case series summarizes superiority of using intranasal mometasone furoate spray (IMS) and continuous...
The relation between dizziness and suspected obstructive sleep apnoea: ConclusionThe prevalence of a high risk of OSA in male patients with dizziness is high and a higher risk of OSA is associated with more dizziness-related impairments. A high risk of OSA is not associated with unexplained dizziness or with hyperventilation/anxiety disorders. (Source: European Archives of Oto-Rhino-Laryngology)
Objectivation of laryngeal electromyography (LEMG) data: turn number vs. qualitative analysis: ConclusionsOur preliminary results showed that turn number evaluation is an effective tool to confirm LEMG qualitative analysis, and that, in combination with laryngostroboscopy and voice assessment, can help improving the accuracy of the diagnosis and prognosis and the effectiveness of the chosen therapy. (Source: European Archives of Oto-Rhino-Laryngology)
Superomedial partial arytenoidectomy for voice improvement by correction of posterior glottic insufficiency: ConclusionSPA is a safe and efficient procedure for voice improvement in patients with posterior glottic insufficiency due to an obstructing anteromedially prolapsed arytenoid. We recommend performing this procedure combined with injection augmentation. (Source: European Archives of Oto-Rhino-Laryngology)
Importance of signal intensity on T1-weighted spin-echo sequence for the diagnosis of chronic cholesteatomatous otitis: ConclusionOur study showed that combining a nonEPDW sequence with the quantitative analysis of contrast-free T1W SE sequence in pre-operative patients enables the correct diagnosis of cholesteatoma with good sensitivity and specificity (> 90%) and reduces risks of false-positive cases for surgeons. (Source: European Archives of Oto-Rhino-Laryngology)
Coblation versus microdebrider-assisted turbinoplasty for endoscopic inferior turbinates reduction: Patients suffering from persistent inferior turbinates hypertrophy refractory to medical treatments require surgical intervention where the main aim is symptomatic relief without any complications. Extraturbinoplasty is one of the preferred procedures for turbinate reduction due to its efficacy in freeing up nasal space by removing the obstructing soft tissue and bone while preserving the turbinate...
Classification of laryngeal injury in patients with prolonged intubation and to determine the factors that cause the injury: Publication date: Available online 17 February 2020Source: American Journal of OtolaryngologyAuthor(s): Dursun Mehmet Mehel, Doğukan Özdemir, Mehmet Çelebi, Samet Aydemir, Gökhan Akgül, Abdulkadir ÖzgürAbstractObjectiveThis study aims to evaluate injuries occurring in the larynx of patients intubated in intensive care units for a long time.Study designProspective clinical study.SettingTertiary...
Identification of key candidate genes and pathways in anaplastic thyroid cancer by bioinformatics analysis: Publication date: Available online 17 February 2020Source: American Journal of OtolaryngologyAuthor(s): Yong-Gang Ding, Yu-Lin Ren, Yang-Shan Xu, Chang-Sheng Wei, Yong-Bin Zhang, Shou-Kai Zhang, Chang-An GuoAbstractBackgroundAnaplastic thyroid carcinoma (ATC) is a refractory and poor prognosis tumor Present study aimed to investigate the underlying biological functions and pathways involved...
Effects of semantic categorization strategy training on episodic memory in children and adolescents: by Eliane C. Miotto, Joana B. Balardin, Maria da Graça M. Martin, Guilherme V. Polanczyk, Cary R. Savage, Euripedes C. Miguel, Marcelo C. BatistuzzoEpisodic memory is the ability to learn, store and recall new information. The prefrontal cortex (PFC) is a crucial area engaged in this ability. Cognitive training has been demonstrated to improve episodic memory in adults and older subjects. However,...
Open rhinoplasty using a columellar strut: effects of the graft on nasal tip projection and rotation.: Related ArticlesOpen rhinoplasty using a columellar strut: effects of the graft on nasal tip projection and rotation.Eur Arch Otorhinolaryngol. 2020 Feb 15;:Authors: Bucher S, Kunz S, Deggeller M, Holzmann D, Soyka MBAbstract BACKGROUND: Despite the discordance in the literature concerning the effect of columellar strut grafts on nasal tip rotation, this method is often used when an increase...
One-pot synthesis of Cr(III)-incorporated Zr(IV) oxide for fluoride remediation: a lab to field performance evaluation study: AbstractA low-cost Cr(III)-incorporated Zr(IV) bimetallic oxide (CZ) was synthesized by simple chemical precipitation method for removal of fluoride from contaminated water. The physicochemical properties of CZ before and after fluoride removal were established with several instrumental techniques such as TEM with elemental mapping, SEM with EDX, XRD, IR, XPS, zeta potential...
A feasibility study of OCT for anatomical and vascular phenotyping of mouse embryo: AbstractThe embryo phenotyping of genetic murine model is invaluable when investigating functions of genes underlying embryonic development and birth defect. Although traditional imaging technologies such as ultrasound are very useful for evaluating phenotype of murine embryos, the use of advanced techniques for phenotyping is desirable to obtain more information from genetic research. This letter tests the feasibility...
Utility of Valsalva maneuver in the endoscopic pharyngeal observation: AbstractBackgroundMetachronous cancer rate in the pharynx is high before and after the treatment of esophageal cancer. Endoscopic observation is difficult in the pharynx especially in the postcricoid area. Pharyngeal cancer in the postcricoid area has been often found in advanced stage. Valsalva maneuver has been reported to improve the visibility.MethodsFrom May 2017 we introduced a dedicated mouthpiece to conduct Valsalva maneuver....
Roles of omalizumab in various allergic diseases: Publication date: Available online 14 February 2020Source: Allergology InternationalAuthor(s): Yoshimichi Okayama, Hisako Matsumoto, Hiroshi Odajima, Shunsuke Takahagi, Michihiro Hide, Kimihiro OkuboAbstractIgE and mast cells play a pivotal role in various allergic diseases, including asthma, allergic rhinitis, and urticaria. Treatment with omalizumab, a monoclonal anti-IgE antibody, has significantly improved control of these allergic diseases and...
Laparoscopic esophagogastrostomy using a knifeless linear stapler after proximal gastrectomy.: Related ArticlesLaparoscopic esophagogastrostomy using a knifeless linear stapler after proximal gastrectomy.Surg Today. 2019 Dec;49(12):1080-1086Authors: Ohi M, Toiyama Y, Kitajima T, Shigemori T, Yasuda H, Okugawa Y, Fujikawa H, Okita Y, Yokoe T, Hiro J, Araki T, Kusunoki MAbstract Proximal gastrectomy should improve the late postoperative function in patients with gastric cancer located in the...
Gastric Acid and Pepsin Work Together in Simulated Gastric Acid Inhalation Leading to Pulmonary Fibrosis in Rats.: Related ArticlesGastric Acid and Pepsin Work Together in Simulated Gastric Acid Inhalation Leading to Pulmonary Fibrosis in Rats.Med Sci Monit. 2019 Aug 16;25:6153-6164Authors: Chen S, Chen H, Cheng Y, Wei Y, Zhou X, Li T, Zhu J, Wang QAbstract BACKGROUND The clinical association between gastroesophageal reflux disease (GERD) and idiopathic pulmonary fibrosis (IPF) has been...
Oesophageal screening during videofluoroscopy: International practices and perspectives of speech-language pathologists.: Related ArticlesOesophageal screening during videofluoroscopy: International practices and perspectives of speech-language pathologists.Int J Speech Lang Pathol. 2020 Feb 13;:1-10Authors: Regan J, Wiesinger T, Keane J, Walshe MAbstract Purpose: The aim of this study was to investigate international oesophageal screening (OS) practices during videofluoroscopy (VFS) amongst...
Endoscopic radial incision method for two strictures of the esophagus after endoscopic submucosal dissection: a case report.: Related ArticlesEndoscopic radial incision method for two strictures of the esophagus after endoscopic submucosal dissection: a case report.World J Surg Oncol. 2020 Feb 13;18(1):38Authors: Huang Z, Wei W, Cheng FAbstract BACKGROUND: The development of severe esophageal stricture after endoscopic submucosal dissection (ESD) for early esophageal carcinoma is not uncommon....
Central nervous system tuberculoma with miliary tuberculosis in the elderly.: Related ArticlesCentral nervous system tuberculoma with miliary tuberculosis in the elderly.IDCases. 2020;19:e00710Authors: Tetsuka S, Suzuki T, Ogawa T, Hashimoto R, Kato HAbstract The aging phenomenon of tuberculosis (TB) patients is recognized all over the world, but no country is as prominent as Japan. Central nervous system (CNS) TB includes clinical entities: tuberculous meningitis, intracranial tuberculoma,...
Clinical features and genetic characteristics of hereditary diffuse leukoencephalopathy with spheroids due to CSF1R mutation: a case report and literature review.: Related ArticlesClinical features and genetic characteristics of hereditary diffuse leukoencephalopathy with spheroids due to CSF1R mutation: a case report and literature review.Ann Transl Med. 2020 Jan;8(1):11Authors: Zhuang LP, Liu CY, Li YX, Huang HP, Zou ZYAbstract Background: Hereditary diffuse leukoencephalopathy with spheroid...
Radiotherapy for Thoracic Esophageal Squamous Cell Carcinoma.: Related ArticlesRadiotherapy for Thoracic Esophageal Squamous Cell Carcinoma.Methods Mol Biol. 2020;2129:307-319Authors: Chan WWL, Lam KO, Kwong DLWAbstract Esophageal squamous cell carcinoma (ESCC) is an aggressive disease. Many patients have locally advanced disease or already have distant metastasis at presentation. Radiotherapy plays an important role in the treatment of esophageal squamous cell carcinoma. Neoadjuvant chemoradiotherapy...
Clinical outcomes for larynx patients with cancer treated with refinement of high-dose radiation treatment volumes.: Related ArticlesClinical outcomes for larynx patients with cancer treated with refinement of high-dose radiation treatment volumes.Head Neck. 2020 Feb 14;:Authors: Burr AR, Harari PM, Haasl AM, Wieland AM, Bruce JY, Kimple RJ, Hartig GK, McCulloch TM, Witek MEAbstract BACKGROUND: To evaluate disease control, toxicities, and dose to dysphagia/aspiration risk structures (DARS)...
Trans-oral robotic surgery in the management of parapharyngeal space tumors: A systematic review.: Related ArticlesTrans-oral robotic surgery in the management of parapharyngeal space tumors: A systematic review.Oral Oncol. 2020 Feb 11;103:104581Authors: De Virgilio A, Costantino A, Mercante G, Di Maio P, Iocca O, Spriano GAbstract PURPOSE: To perform a systematic review of studies evaluating Trans-oral Robotic Surgery (TORS) in the treatment of parapharyngeal space (PPS) tumors. METHODS:...
A rare case of acquired benign tracheoesophageal fistula: AbstractAcquired benign tracheoesophageal fistula (TOF) is a rare medical condition that usually results from trauma, foreign bodies or granulomatous infections. This is an unusual presentation of a male patient with a history of laryngectomy who has had over a period of several years inappropriately and vigorously used valve cleaning brushes to clean tracheal secretions, which has led to the formation of a TOF. Due to the patient's obsessive...
Atrial myxoma with cerebellar signs: a case report: Atrial myxoma remains a rare clinical entity with an incidence of surgically resected cases of 0.5–0.7 per million population and prevalence of
A Remarkable Remission: Treating HMA Refractory Transforming MDS with Single-Agent Low-Dose Cytarabine Leading to an Ongoing Six-Year OS: Hypomethylating agents (HMA) are the standard of care for patients ≥65 years with intermediate-high risk myelodysplastic syndrome (MDS) unsuitable for intensive therapy or stem cell transplant (SCT). However, many patients will develop relapse/refractory disease, at which point limited treatment options remain. There has been a lot of research into investigational...
Diffusion MRI Findings in Encephalopathy Induced by Immunosuppressive Therapy after Liver Transplantation: Neurological complications are common after liver transplantation, as they affect up to one-third of the transplanted patients and are associated with significant morbidity. The introduction of calcineurin inhibitors, cyclosporine A and tacrolimus, in immunosuppressive regimens significantly improved the outcome of solid-organ transplantation even though immunosuppression-associated neurotoxicity...
Metastatic malignancy mimics: a rare case of traumatic splenosis mimicking intra-abdominal malignancy: We present a case of a patient, undergoing imaging for an unrelated presentation, whose adolescent abdominal trauma had caused an unrecognised disseminated intra-abdominal splenosis, resulting in an imaging presentation on CT that suggested intra-abdominal malignancy. The lack of correlative symptoms of disseminated malignancy, in addition to imaging findings suggesting previous upper abdominal...
Hyperparathyroidism in pregnancy: Hyperparathyroidism is a rare disease during pregnancy, which has increased risks, including miscarriage and fetal growth restriction. However, the diagnosis of hyperparathyroidism is frequently not recognised or delayed as symptoms are non-specific and calcium is not routinely measured. With a thorough medical history and clinical suspicion, early diagnosis and treatment can reduce the risk of some pregnancy complications. A 35-year-old woman presented at 13/40...
Hyperparathyroidism in pregnancy: Hyperparathyroidism is a rare disease during pregnancy, which has increased risks, including miscarriage and fetal growth restriction. However, the diagnosis of hyperparathyroidism is frequently not recognised or delayed as symptoms are non-specific and calcium is not routinely measured. With a thorough medical history and clinical suspicion, early diagnosis and treatment can reduce the risk of some pregnancy complications. A 35-year-old woman presented at 13/40...
Rasmussens aneurysm masquerading as mass lesion: Haemoptysis is an often encountered respiratory symptom. The amount of haemoptysis varies from mild to life-threatening severity and may indicate the underlying pulmonary disorder. Herein, we report a 50-year-old male smoker who presented with occasional streaky to mild haemoptysis for last 1 year. He had pulmonary tuberculosis 10 years ago and had received adequate treatment. Chest radiograph was suspicious of a mass lesion in left upper lung. Contrast-enhanced...
Posterior reversible encephalopathy syndrome associated with the use of chemotherapeutic agents: a rare complication after treatment with vinorelbine: The posterior reversible encephalopathy syndrome (PRES) is a clinicoradiological syndrome characterised by a combination of headache, encephalopathy, seizures and visual disturbances, associated with high-intensity abnormalities on T2-weighted images affecting subcortical white and grey matter of the occipital and parietal lobes. Among other causes,...
Tubulointerstitial nephritis and uveitis (TINU) syndrome and recent Streptococcus infection in a 9-year-old girl: A 9-year-old girl presented to hospital with a 6-week history of non-specific constitutional symptoms and weight loss. She initially underwent extensive medical investigation without diagnosis being achieved. Although raised inflammatory markers and impaired renal function were noted during her initial admission to hospital, it was her subsequent presentation 2 weeks later with sudden-onset...
Rapidly fatal pneumococcal meningitis following non-penetrating traumatic brain injury: A previously healthy young man presented to hospital with severe traumatic brain injury following a motor vehicle collision. Within 24 hours of admission, and despite antibiotic coverage, he developed a fever. On the second day, the source of infection was discovered to be purulent pneumococcal meningitis. At 48 hours post-accident, he developed brain-stem death without evidence of raised intracranial pressure...
Mucinous breast carcinoma metastatic to thyroid gland: Report of a case diagnosed by fine‐needle aspiration cytology: AbstractMucinous breast cancer is a slow‐growing neoplasm, which has fewer lymph node metastases and favorable prognosis compared with invasive breast cancer no special type. The hematogenous spread of breast mucinous carcinoma is very rare. Though breast cancer involving thyroid has been reported before, there is still no report about thyroid metastatic breast mucinous carcinoma...
Maligne Rundzelltumoren: ZusammenfassungEwing-Sarkome stellen hochmaligne Tumoren dar, die hauptsächlich bei Kindern und Jugendlichen anzutreffen sind. Neben einer frühen klinischen Diagnostik stellt die korrekte histopathologische und molekulargenetische Klassifizierung den wichtigsten Schritt dar. Zwar stellt die EWSR1-FLI1-Fusion die mit Abstand häufigste nachweisbare Veränderung dar, aber es gibt auch weitere, histopathologisch und immunhistochemisch nicht von klassischen Ewing-Sarkomen zu unterscheidende...
Der jüdische Oralpathologe Bernhard Gottlieb (1885–1950) und seine wissenschaftliche „Entwurzelung" im „Dritten Reich": ZusammenfassungAls Adolf Hitler 1938 den Anschluss Österreichs an das Deutsche Reich vollzog, gelangte der berühmte jüdische Oralpathologe Bernhard Gottlieb in große Bedrängnis. Der Wiener Hochschullehrer verlor umgehend seine Anstellung und Lehrbefugnis und sah sich zur Emigration gezwungen.Während die wissenschaftliche Ausnahmestellung Gottliebs innerhalb der internationalen Oralpathologie...
Knorpeltumoren: Morphologie, Genetik und Basisaspekte der Targettherapie: ZusammenfassungKnorpeltumoren sind eine heterogene Gruppe von mesenchymalen Tumoren, deren gemeinsames Charakteristikum die Bildung von chondroblastisch differenzierter Grundsubstanz durch die Tumorzellen ist. Die Grundzüge ihrer histologischen Klassifikation wurden bereits in den 1940er-Jahren entwickelt mit Ergänzungen durch weitere Entitäten in den darauffolgenden Jahrzehnten. Grundlegend neue Erkenntnisse wurden dann erst...
Late Recurrence in Ovarian Dysgerminoma Presenting as a Primary Retroperitoneal Tumor: A Case Report and Review of the Literature: Ovarian dysgerminoma is a rare type of germ cell tumor. The majority of patient relapses occur within 2 years of diagnosis. Here, we report the case of a 74-year-old woman with a history of ovarian dysgerminoma 39 years earlier. The patient visited the hospital presenting with heartburn. An abdominal computed tomography (CT) revealed a right retroperitoneal mass, and...
Digital Whole Slide Imaging Compared With Light Microscopy for Primary Diagnosis in Surgical Pathology: A Multicenter, Double-Blinded, Randomized Study of 2045 Cases.: Related ArticlesDigital Whole Slide Imaging Compared With Light Microscopy for Primary Diagnosis in Surgical Pathology: A Multicenter, Double-Blinded, Randomized Study of 2045 Cases.Arch Pathol Lab Med. 2020 Feb 14;:Authors: Borowsky AD, Glassy EF, Wallace WD, Kallichanda NS, Behling CA, Miller DV, Oswal HN, Feddersen RM, Bakhtar...
The 2018 World Health Organization Classification of Cutaneous, Mucosal, and Uveal Melanoma: Detailed Analysis of 9 Distinct Subtypes Defined by Their Evolutionary Pathway.: Related ArticlesThe 2018 World Health Organization Classification of Cutaneous, Mucosal, and Uveal Melanoma: Detailed Analysis of 9 Distinct Subtypes Defined by Their Evolutionary Pathway.Arch Pathol Lab Med. 2020 Feb 14;:Authors: Elder DE, Bastian BC, Cree IA, Massi D, Scolyer RAAbstract CONTEXT.—: There have been major...
Isolated tumor cells in the regional lymph nodes in patients with squamous cell carcinoma of the esophagus are rarely observed but often represent part of a true metastasis: Publication date: Available online 14 February 2020Source: Annals of Diagnostic PathologyAuthor(s): Dea Natalie Munch Jepsen, Anne-Marie Kanstrup Fiehn, Bonnie Svendsen, Michael Patrick Achiam, Birgitte FederspielAbstractThe most common malignancy of the esophagus is squamous cell carcinoma (SCC) and regional lymph node metastases...
Spectrum of histological features of Denosumab treated Giant Cell Tumor of Bone; Potential pitfalls and diagnostic challenges for pathologists: Publication date: Available online 14 February 2020Source: Annals of Diagnostic PathologyAuthor(s): Muhammad Usman Tariq, Masood Umer, Zeeshan Khan, Javeria Saeed, Muhammad Ather Siddiqi, Nasir Ud DinAbstractObjectivesDenosumab is Receptor Activator of Nuclear factor Kappa-B Ligand (RANKL) inhibitor which is being used in the treatment of locally advanced,...
American registry of pathology expert opinions: The spectrum of lobular carcinoma in situ: Diagnostic features and clinical implications: Publication date: Available online 15 February 2020Source: Annals of Diagnostic PathologyAuthor(s): Stuart J. Schnitt, Edi Brogi, Yunn-Yi Chen, Tari A. King, Sunil R. LakhaniAbstractThis review reflects a collaboration between the American Registry of Pathology (the publisher of the Armed Forces Institute of Pathology Fascicles) and Annals of Diagnostic Pathology....
Sevoflurane sedation attenuates early cerebral oedema formation through stabilisation of the adherens junction protein beta catenin in a model of subarachnoid haemorrhage: A randomised rat study: BACKGROUND Severe neurological impairment is a problem after subarachnoid haemorrhage (SAH). Although volatile anaesthetics, such as sevoflurane, have demonstrated protective properties in many organs, their use in cerebral injury is controversial. Cerebral vasodilation may lead to increased intracranial...
Effect of an ultrasound-guided lung recruitment manoeuvre on postoperative atelectasis in children: A randomised controlled trial: BACKGROUND Ultrasound-guided alveolar recruitment, regardless of the technique, could be more effective because it facilitates real-time monitoring of the expansion of collapsed alveoli.OBJECTIVES To evaluate and compare the effects of an ultrasound-guided lung recruitment manoeuvre with those of a conventional recruitment manoeuvre on the occurrence of postoperative...
Risk of Postdural Puncture Headache in Adolescents and Adults: BACKGROUND: Spinal anesthesia is known to have numerous benefits, including reductions in nausea and opioid consumption; however, postdural puncture headache (PDPH) remains a significant risk associated with this technique. The literature specifically examining this complication in adolescents is scarce. Our primary objective was therefore (1) to estimate the incidence of PDPH with a 27G pencil-point needle in patients between the ages...
Impact of Intraoperative Cell Salvage on Blood Coagulation Factor Concentrations in Patients Undergoing Cardiac Surgery: BACKGROUND: Cardiothoracic surgery is associated with major blood loss and allogeneic transfusion of red blood cell concentrates. To minimize allogeneic red blood cell (RBC) transfusion, intraoperative cell salvage has been effectively used for years. The objective of this study was to evaluate the impact of cell salvage on blood coagulation factors.METHODS: We enrolled 30 patients...
Trachoma Prevalence After Discontinuation of Mass Azithromycin Distribution: AbstractBackgroundAs the World Health Organization seeks to eliminate trachoma by 2020, countries are beginning to control the transmission of trachomatous inflammation–follicular (TF) and discontinue mass drug administration (MDA) with oral azithromycin. We evaluated the effect of MDA discontinuation on TF1–9 prevalence at the district level.MethodsWe extracted from the available data districts with an impact survey at...
A Protein Epitope Targeted by the Antibody Response to Kawasaki Disease: AbstractBackgroundKawasaki disease (KD) is the leading cause of childhood acquired heart disease in developed nations and can result in coronary artery aneurysms and death. Clinical and epidemiologic features implicate an infectious cause, but specific antigenic targets of the disease are unknown. Peripheral blood plasmablasts are normally highly clonally diverse but the antibodies they encode are ~70% antigen-specific 1-2 weeks...
Post-vaccination serum anti-rotavirus immunoglobulin A as a correlate of protection against rotavirus gastroenteritis across settings: AbstractBackgroundA correlate of protection for rotavirus gastroenteritis would facilitate rapid assessment of vaccination strategies and the next generation of rotavirus vaccines. We aimed to quantify a threshold of post-vaccine serum anti-rotavirus immunoglobulin A (IgA) that serves as an individual-level immune correlate of protection against rotavirus gastroenteritis.MethodsIndividual-level...
Sirolimus and other mTOR inhibitors directly activate latent pathogenic human polyomavirus replication: AbstractBackgroundHuman polyomaviruses can reactivate in transplant patients causing nephropathy, progressive multifocal leukoencephalopathy, Merkel cell carcinoma, pruritic rash or trichodysplasia spinulosa. Sirolimus and related mTOR inhibitors are transplant immunosuppressants. It is unknown if they directly reactivate polyomavirus replication from latency beyond their general effects on immunosuppression.MethodsIn...
Association of Viral Load With Disease Severity in Outpatient Children With Respiratory Syncytial Virus Infection: AbstractBackgroundThere are scarce data on whether viral load affects the severity of respiratory syncytial virus (RSV) disease in outpatient children.MethodsWe analyzed the association between viral load and disease severity among children who participated in a prospective cohort study of respiratory infections. The children were examined and nasal swabs for the detection of RSV were...
A familial cluster of infection associated with the 2019 novel coronavirus indicating potential person-to-person transmission during the incubation period: AbstractAn ongoing outbreak of pneumonia associated with 2019 novel coronavirus (2019-nCoV) was reported in China. It is unclear if the infectivity exists during the incubation period, although a person-to-person transmission has been reported in previous studies. We report the epidemiological features of a familial cluster of four patients in...
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Ayurveda episteme on quality of life parametersSrihari SheshagiriJournal of Indian System of Medicine 2019 7(3):139-141Hepatoprotective action of Nagdantyadi ghrita: A literature reviewAbhijeet A Gawai, Sonali P ChalakJournal of Indian System of Medicine 2019 7(3):142-145Background: Ayurveda, an ancient system of medicine with rich heritage and antiquity, is well known since Vedic period. The use of Nagdantyadi ghrita (NG) and its ingredients has been well-defined in ancient Ayurveda literature Charaka...
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A cross-sectional observation to investigate subsequent cardiovascular diseases in Taiwanese men with erectile dysfunctionChieh-Wen Chin, Bang-Ping JiannFormosan Journal of Surgery 2020 53(1):1-7Background: Erectile dysfunction (ED) is regarded as a warning of systemic disease. Controversy still exists in the relationship between ED and subsequent cardiovascular disease (CVD). This study aims to investigate the incidence and the interval of subsequent CVD in Taiwanese men who initially presented...
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