International Journal of Environmental Research and Public HealthIJERPH, Vol. 17, Pages 535: Invasive Basidiobolomycosis Presenting as Retroperitoneal Fibrosis: A Case ReportIJERPH, Vol. 17, Pages 535: Invasive Basidiobolomycosis Presenting as Retroperitoneal Fibrosis: A Case Report International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17020535 Authors: Abdulmalek Alsharidah Yahya Mahli Nayef Alshabyli Mohammed Alsuhaibani Basidiobolomycosis is an uncommon emerging...
10:38
International Journal of Neonatal ScreeningIJNS, Vol. 6, Pages 2: Two-Tiered Newborn Screening with Post-Analytical Tools for Pompe Disease and Mucopolysaccharidosis Type I Results in Performance Improvement and Future DirectionIJNS, Vol. 6, Pages 2: Two-Tiered Newborn Screening with Post-Analytical Tools for Pompe Disease and Mucopolysaccharidosis Type I Results in Performance Improvement and Future Direction International Journal of Neonatal Screening doi: 10.3390/ijns6010002 Authors: Hall Sanchez...
10:37
AntibioticsAntibiotics, Vol. 9, Pages 28: Effect of α-Bisabolol and Its β-Cyclodextrin Complex as TetK and NorA Efflux Pump Inhibitors in Staphylococcus aureus StrainsAntibiotics, Vol. 9, Pages 28: Effect of α-Bisabolol and Its β-Cyclodextrin Complex as TetK and NorA Efflux Pump Inhibitors in Staphylococcus aureus Strains Antibiotics doi: 10.3390/antibiotics9010028 Authors: Pereira da Cruz Sampaio de Freitas Socorro Costa Lucas dos Santos Ferreira Campina Pereira Bezerra Quintans-Júnior De Souza...
10:35
1apb65-evovr.htmlAccepted Articles Alert_ Dermatologic Therapy.eml 2a8z5i-mae98.htmlAccepted Articles Alert_ Experimental Dermatology.eml 3aavtt-dyaal.htmlAccepted Articles Alert_ Journal of Cutaneous Pathology.eml 4a2fok-nhvyq.htmlAddiction Science & Clinical Practice, Vol. 14, Issue 1 - New Issue Alert.eml 5a10sp-1gwcj.htmlAIDS and Behavior, Vol. 24, Issue 1 - New Issue Alert.eml 6as6ns-ikhdf.htmlAnesthesiology Featured Articles Alert.eml 7al1jt-csdg0.htmlAnesthesiology Online First.eml 8ap8t6-ft6vh.htmlAPIK...
10:10
Building Consensus to Decrease Firearm Injuries and Death in the USA: Engaging Medical and Public Health Organizations to Find Common Ground: AbstractPurpose of ReviewFirearm injury deaths are rising and as of 2017 exceed motor vehicle crash deaths in the USA. We as healthcare professionals treat many of the injured, including those cared for in the network of over 560 ACS-verified trauma centers. In order to address this public health crisis that affects us all, we need to develop a multifaceted...
08:31
Toward Integration of mHealth in Primary Care in the Netherlands: A Qualitative Analysis of Stakeholder Perspectives: Background: There is a growing need to structurally change the way chronic illness care is organized as health systems struggle to meet the demand for chronic care. mHealth technologies can alter traditional approaches to health care provision by stimulating self-management of chronically ill patients. The aim of this study was to understand the complex environment related to the...
08:31
Original Article Open AccessGlobal Capnography Project (GCAP): implementation of capnography in Malawi – an international anaesthesia quality improvement projectR. Jooste F. Roberts S. Mndolo D. Mabedi S. Chikumbanje D. K. Whitaker E. P. O'SullivanFirst published: 25 September 2018 https://doi.org/10.1111/anae.14426 Citations: 7This article is accompanied by an editorial by Lipnick et al., Anaesthesia 2019; 74: 146‐149.You can respond to this article at http://www.anaesthesiacorrespondence.comSECTIONSPDF0COMMENTS TOOLS SHARESummaryThe...
Tue Jan 14, 2020 12:57
NAP4 Report and findings of the 4th National Audit Project of The Royal College of Anaesthetists ■ ■ ■ ■ ■Executive SummaryWhile it is generally accepted that airway management maysometimes be problematic and that complications occur, itwas not known how frequently these occur or the nature ofthe events. NAP4 sets out to address this.The 4th National Audit Project of the Royal College ofAnaesthetists and the Difficult Airway Society (NAP4) wasdesigned to answer the questions;■ What types of airway...
Tue Jan 14, 2020 12:50
GSE125121 RNA sequencing of host transcriptome of human foreskin fibroblast cells infected with either bradyzoites and tachyzoite of Toxoplasma gondiiContributors : Simona Seizova ; Chris J Tonkin ; Alexandra L GarnhamSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiens ; Toxoplasma gondiiThe purpose of this data set is to determine if bradyzoites impact the host transcripton in a similar manner as tachyzoites. We found that 3853 differentially expressed genes (DEGs)...
09:16
Obstructive sleep apnea in developmental age. A narrative review: AbstractSleep is a physiological function that undergoes, at different stages of life, to considerable variations in neurophysiological and behavioral functions. The developmental age is a period characterized by a continuous process of physical and neuropsychological changes and synaptic remodeling processes that are the neurophysiological basis of brain plasticity, typical of this developmental phase, occurring mainly during sleep....
09:15
Acute stroke and TIA patients have specific polygraphic features of obstructive sleep apnea: AbstractPurposeObstructive sleep apnea (OSA) is associated with increased risk for stroke, which is known to further impair respiratory functions. However, it is unknown whether the type and severity of respiratory events are linked to stroke or transient ischemic attack (TIA). Thus, we investigate whether the characteristics of individual respiratory events differ between patients experiencing TIA or acute...
09:14
Dual Pathologies: Pial Arteriovenous Fistula in Combination with an Arteriovenous Malformation: J Neurol Surg A Cent Eur NeurosurgDOI: 10.1055/s-0039-1698398Background A pial arteriovenous fistula (PAVF) is a rare neurovascular pathology consisting of a direct connection between one or more arterial feeders and a single venous channel. A PAVF was previously considered a subtype of an arteriovenous malformation (AVM). In the current literature these are distinguished as two independent entities with...
09:14
Somatosensory Evoked Potential and Transcranial Doppler Monitoring to Guide Shunting in Carotid Endarterectomy: J Neurol Surg A Cent Eur NeurosurgDOI: 10.1055/s-0039-1698441Objective Clamping of the internal carotid artery (ICA) during carotid endarterectomy (CEA) is a critical step. In our neurosurgical department, CEAs are performed with transcranial Doppler (TCD) and somatosensory evoked potential (SEP) monitoring with a 50% flow velocity/amplitude decrement warning criteria for shunting. The...
09:13
Three-dimensional position of mandibular third molars and its association with distal caries in mandibular second molars: a cone beam computed tomographic study: AbstractObjectiveTo analyze the prevalence of distal caries in mandibular second molars (M2Ms) and its correlation with the three-dimensional position of mandibular third molars (M3Ms) by cone beam computed tomography (CBCT) images.Materials and methodsCBCT scans involving 421 M3Ms were assessed. The presence of distal caries of M2Ms, patient...
09:13
Early Rupture of a Giant Basilar Artery Aneurysm after LEO Stenting: Case Report and Review of the Literature: J Neurol Surg A Cent Eur NeurosurgDOI: 10.1055/s-0039-1693108Background Advances in the endovascular armamentarium, such as flow diversion and stenting devices, provide treatment options for posterior circulation intracranial aneurysms (IAs) with complex angioarchitecture. Delayed IA rupture following flow diversion is a rare but often fatal complication. Giant IAs likely pose a higher risk...
09:13
Impact of Priming on Effectiveness of TMS in Detecting Language-eloquent Brain Areas in Tumor Patients: J Neurol Surg A Cent Eur NeurosurgDOI: 10.1055/s-0039-1698382Background and Study Aims Language is characteristically human, and preserving it is critical when resecting tumors in language-eloquent brain areas. Navigated repetitive transcranial magnetic stimulation (nrTMS) has been used in recent years as a noninvasive technique to identify preoperatively the language-eloquent cortical areas in...
09:13
Endoscopic 4-MHz Radiofrequency Treatment of Facet Joint Syndrome Is More Than Just Denervation: One Incision for Three Facets: J Neurol Surg A Cent Eur NeurosurgDOI: 10.1055/s-0039-1698397Background and Study Aims Low back pain is well documented as an extremely common health problem. The most frequently used treatment is radiofrequency denervation for chronic low back pain. However, different clinical studies could only show a limited to no improvement regarding the decrease of pain intensity and...
09:13
Symptomatic Postoperative Spinal Epidural Hematoma after Spinal Decompression Surgery: Prevalence, Risk Factors, and Functional Outcome: J Neurol Surg A Cent Eur NeurosurgDOI: 10.1055/s-0039-1697024Objective Postoperative spinal epidural hematoma (pSEH) with symptomatic compression of nervous structures after spinal decompression surgery is a rare complication. Delayed evacuation may result in severe neurologic impairment. We present a large single-center analysis of the prevalence, potential risk...
09:13
Continuous Dynamic Mapping to Identify the Corticospinal Tract in Motor Eloquent Brain Tumors: An Update: J Neurol Surg A Cent Eur NeurosurgDOI: 10.1055/s-0039-1698384Objective We recently developed a new subcortical mapping technique based on the concept of stimulating the tissue at the site of and synchronously with resection. Our hypothesis was that instead of performing resection and mapping sequentially, a synchronized resection and mapping could potentially improve deficit rates. ...
09:13
Gingival recession after scaling and root planing with or without systemic metronidazole and amoxicillin: a re-review: AbstractBackgroundGingival recessions inevitably occur during healing after scaling and root planing, but synoptic data on this topic is still lacking. This review compared the recession formation with and without the administration of systemic antibiotics.ObjectivesTo evaluate the formation of recession with and without the administration of antibiotics during the healing after...
09:12
GSE125121 RNA sequencing of host transcriptome of human foreskin fibroblast cells infected with either bradyzoites and tachyzoite of Toxoplasma gondiiContributors : Simona Seizova ; Chris J Tonkin ; Alexandra L GarnhamSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiens ; Toxoplasma gondiiThe purpose of this data set is to determine if bradyzoites impact the host transcripton in a similar manner as tachyzoites. We found that 3853 differentially expressed genes (DEGs)...
09:11
Lyme aortitis: A 72-year-old man was admitted with complaints of sudden-onset oppressive precordial pain radiating to the back for 1 hour. He had hypotension, peripheral cyanosis and cold extremities. An initial assessment was done and acute coronary syndrome was excluded. After the patient was admitted, he developed fever and increased levels of inflammatory markers. Data obtained from CT angiography and transoesophageal echocardiogram revealed diffuse parietal thickening of the arch and the descending...
09:09
Autologous Cell Harvesting and Processing Devices for Burns: What benefits do autologous cell harvesting and processing devices offer in the treatment of burn injuries in children? Wounds
09:09
Development of a Cannabis Assessment Tool (CAT-1) to measure current and lifetime marijuana use among older Veterans: ObjectiveTo develop a tool to assess current (past 30 days) and lifetime marijuana use in older Veterans.SettingUS Veteran's Affairs Healthcare System.Participants704 older Veterans were screened, 339 completed the initial survey, 100 completed the follow-up.Primary outcome measurePearson's correlation coefficient to assess strength of association between initial and follow-up survey...
09:09
Acute stroke and TIA patients have specific polygraphic features of obstructive sleep apnea: AbstractPurposeObstructive sleep apnea (OSA) is associated with increased risk for stroke, which is known to further impair respiratory functions. However, it is unknown whether the type and severity of respiratory events are linked to stroke or transient ischemic attack (TIA). Thus, we investigate whether the characteristics of individual respiratory events differ between patients experiencing TIA or acute...
09:08
Developing the evidence base for evaluating dementia training in NHS hospitals (DEMTRAIN): a mixed-methods study protocol: IntroductionAround 70% of acute hospital beds in the UK are occupied by older people, approximately 40% of whom have dementia. Improving the quality of care in hospitals is a key priority within national dementia strategies. Limited research has been conducted to evaluate dementia training packages for staff, and evaluation of training often focuses on immediate, on-the-day training...
09:08
Is subjective well-being independently associated with mortality? A 14-year prospective cohort study in a representative sample of 25 139 US men and women: ObjectivesTo examine whether the inverse association of subjective well-being with mortality is independent of self-rated health and socioeconomic status in healthy adults.DesignA population-based prospective cohort study based on an in-person interview. Cox regression was used to examine mortality hazards for happiness alone and for a standardised...
09:08
Cholinesterase alterations in delirium after cardiosurgery: a German monocentric prospective study: ObjectivesPostoperative delirium (POD) is a common complication after elective cardiac surgery. Recent evidence indicates that a disruption in the normal activity of the cholinergic system may be associated with delirium.DesignProspective observational study.SettingSingle-centre at a European academic hospital.Primary and secondary outcome measuresIn our study the enzyme activities of acetylcholinesterase...
09:08
Development and evaluation of a patient decision aid for patients considering ongoing medical or surgical treatment options for ulcerative colitis using a mixed-methods approach: protocol for DISCUSS study: IntroductionApproximately 20%–30% of patients with ulcerative colitis (UC) require surgery, the majority of these being elective due to chronic symptoms refractory to medical treatment. The decision for surgery is difficult and dependent on patient preferences. Current resources for patients considering...
09:08
Development and validation of a Chinese version of the Sleep Apnea Quality of Life Index: AbstractObjectiveA Chinese version of the Sleep Apnea Quality of Life Index (SAQLI) for patients with obstructive sleep apnea (OSA) undergoing treatment with continuous positive airway pressure (CPAP) was developed and validated. No Chinese versions of the SAQLI have been previously validated.MethodsA convenience sample of 78 patients with OSA who received CPAP therapy at a Taiwanese teaching hospital was enrolled....
09:07
Automated multi-model deep neural network for sleep stage scoring with unfiltered clinical data: AbstractPurposeTo develop an automated framework for sleep stage scoring from PSG via a deep neural network.MethodsAn automated deep neural network was proposed by using a multi-model integration strategy with multiple signal channels as input. All of the data were collected from one single medical center from July 2017 to April 2019. Model performance was evaluated by overall classification accuracy,...
09:07
Clinical utility of the Epworth sleepiness scale: AbstractPurposeThe Epworth sleepiness scale (ESS) is a widely used tool which has been validated as a measure of sleepiness. However, the scores within individual patients referred for clinical sleep services vary considerably which may limit the clinical use of the ESS. We sought to determine the test-retest reliability of the ESS if scores were classified as either normal or sleepy.MethodsWe measured the ESS in patients presenting to our sleep center...
09:07
Cochlear Implant Receiver Location and Migration: Experimental Validation Pilot Study of a Clinically Applicable Screening Method: Objectives: Postoperative follow-up after cochlear implantation lacks a reliable screening method to detect cochlear implant receiver device migration. This study aims to validate a clinically applicable method to assess the position and migration of the cochlear implant receiver device.Study design: Validation study.Setting: Tertiary university medical center.Participants...
09:07
Original Article Open AccessGlobal Capnography Project (GCAP): implementation of capnography in Malawi – an international anaesthesia quality improvement projectR. Jooste F. Roberts S. Mndolo D. Mabedi S. Chikumbanje D. K. Whitaker E. P. O'SullivanFirst published: 25 September 2018 https://doi.org/10.1111/anae.14426 Citations: 7This article is accompanied by an editorial by Lipnick et al., Anaesthesia 2019; 74: 146‐149.You can respond to this article at http://www.anaesthesiacorrespondence.comSECTIONSPDF0COMMENTS TOOLS SHARESummaryThe...
Tue Jan 14, 2020 12:57
NAP4 Report and findings of the 4th National Audit Project of The Royal College of Anaesthetists ■ ■ ■ ■ ■Executive SummaryWhile it is generally accepted that airway management maysometimes be problematic and that complications occur, itwas not known how frequently these occur or the nature ofthe events. NAP4 sets out to address this.The 4th National Audit Project of the Royal College ofAnaesthetists and the Difficult Airway Society (NAP4) wasdesigned to answer the questions;■ What types of airway...
Tue Jan 14, 2020 12:50
MDPI International Journal of Molecular SciencesIJMS, Vol. 21, Pages 497: Characterization of the Soybean GmIREG Family Genes and the Function of GmIREG3 in Conferring Tolerance to Aluminum StressIJMS, Vol. 21, Pages 497: Characterization of the Soybean GmIREG Family Genes and the Function of GmIREG3 in Conferring Tolerance to Aluminum Stress International Journal of Molecular Sciences doi: 10.3390/ijms21020497 Authors: Zhandong Cai Peiqi Xian Rongbin Lin Yanbo Cheng Tengxiang Lian Qibin Ma Hai Nian...Medicine...
Tue Jan 14, 2020 10:12
Original Article Open AccessGlobal Capnography Project (GCAP): implementation of capnography in Malawi – an international anaesthesia quality improvement projectR. Jooste F. Roberts S. Mndolo D. Mabedi S. Chikumbanje D. K. Whitaker E. P. O'SullivanFirst published: 25 September 2018 https://doi.org/10.1111/anae.14426 Citations: 7This article is accompanied by an editorial by Lipnick et al., Anaesthesia 2019; 74: 146‐149.You can respond to this article at http://www.anaesthesiacorrespondence.comSECTIONSPDF0COMMENTS TOOLS SHARESummaryThe...
Tue Jan 14, 2020 12:57
NAP4 Report and findings of the 4th National Audit Project of The Royal College of Anaesthetists ■ ■ ■ ■ ■Executive SummaryWhile it is generally accepted that airway management maysometimes be problematic and that complications occur, itwas not known how frequently these occur or the nature ofthe events. NAP4 sets out to address this.The 4th National Audit Project of the Royal College ofAnaesthetists and the Difficult Airway Society (NAP4) wasdesigned to answer the questions;■ What types of airway...
Tue Jan 14, 2020 12:50
1ayzxs-81vrj.htmlAccepted Articles Alert_ British Journal of Dermatology.eml 2a03t9-c6msv.htmlAccepted Articles Alert_ Clinical and Experimental Dermatology.eml 3amd14-lhgq4.htmlActa Oecologica _ Volume 102.eml 4aasl0-y284y.htmlCancer Cell _ Volume 37, Issue 1.eml 5anrwk-b77hf.htmlCentral European Journal of Operations Research, Vol. 28, Issue 1 - New Issue Alert.eml 6at4vw-edba4.htmlClinical Infectious Diseases Advance articles.eml 7algbk-znxwa.htmlClinical Research in Cardiology, Vol. 109, Issue...
Tue Jan 14, 2020 10:22
MDPI International Journal of Molecular SciencesIJMS, Vol. 21, Pages 497: Characterization of the Soybean GmIREG Family Genes and the Function of GmIREG3 in Conferring Tolerance to Aluminum StressIJMS, Vol. 21, Pages 497: Characterization of the Soybean GmIREG Family Genes and the Function of GmIREG3 in Conferring Tolerance to Aluminum Stress International Journal of Molecular Sciences doi: 10.3390/ijms21020497 Authors: Zhandong Cai Peiqi Xian Rongbin Lin Yanbo Cheng Tengxiang Lian Qibin Ma Hai Nian...Medicine...
Tue Jan 14, 2020 10:12
Original Article Open AccessGlobal Capnography Project (GCAP): implementation of capnography in Malawi – an international anaesthesia quality improvement projectR. Jooste F. Roberts S. Mndolo D. Mabedi S. Chikumbanje D. K. Whitaker E. P. O'SullivanFirst published: 25 September 2018 https://doi.org/10.1111/anae.14426 Citations: 7This article is accompanied by an editorial by Lipnick et al., Anaesthesia 2019; 74: 146‐149.You can respond to this article at http://www.anaesthesiacorrespondence.comSECTIONSPDF0COMMENTS TOOLS SHARESummaryThe...
Tue Jan 14, 2020 12:57
NAP4 Report and findings of the 4th National Audit Project of The Royal College of Anaesthetists ■ ■ ■ ■ ■Executive SummaryWhile it is generally accepted that airway management maysometimes be problematic and that complications occur, itwas not known how frequently these occur or the nature ofthe events. NAP4 sets out to address this.The 4th National Audit Project of the Royal College ofAnaesthetists and the Difficult Airway Society (NAP4) wasdesigned to answer the questions;■ What types of airway...
Tue Jan 14, 2020 12:50
MDPI International Journal of Molecular SciencesIJMS, Vol. 21, Pages 497: Characterization of the Soybean GmIREG Family Genes and the Function of GmIREG3 in Conferring Tolerance to Aluminum StressIJMS, Vol. 21, Pages 497: Characterization of the Soybean GmIREG Family Genes and the Function of GmIREG3 in Conferring Tolerance to Aluminum Stress International Journal of Molecular Sciences doi: 10.3390/ijms21020497 Authors: Zhandong Cai Peiqi Xian Rongbin Lin Yanbo Cheng Tengxiang Lian Qibin Ma Hai Nian...Medicine...
Tue Jan 14, 2020 10:12
Original Article Open AccessGlobal Capnography Project (GCAP): implementation of capnography in Malawi – an international anaesthesia quality improvement projectR. Jooste F. Roberts S. Mndolo D. Mabedi S. Chikumbanje D. K. Whitaker E. P. O'SullivanFirst published: 25 September 2018 https://doi.org/10.1111/anae.14426 Citations: 7This article is accompanied by an editorial by Lipnick et al., Anaesthesia 2019; 74: 146‐149.You can respond to this article at http://www.anaesthesiacorrespondence.comSECTIONSPDF0COMMENTS TOOLS SHARESummaryThe...
Tue Jan 14, 2020 12:57
NAP4 Report and findings of the 4th National Audit Project of The Royal College of Anaesthetists ■ ■ ■ ■ ■Executive SummaryWhile it is generally accepted that airway management maysometimes be problematic and that complications occur, itwas not known how frequently these occur or the nature ofthe events. NAP4 sets out to address this.The 4th National Audit Project of the Royal College ofAnaesthetists and the Difficult Airway Society (NAP4) wasdesigned to answer the questions;■ What types of airway...
Tue Jan 14, 2020 12:50
MDPI International Journal of Molecular SciencesIJMS, Vol. 21, Pages 497: Characterization of the Soybean GmIREG Family Genes and the Function of GmIREG3 in Conferring Tolerance to Aluminum StressIJMS, Vol. 21, Pages 497: Characterization of the Soybean GmIREG Family Genes and the Function of GmIREG3 in Conferring Tolerance to Aluminum Stress International Journal of Molecular Sciences doi: 10.3390/ijms21020497 Authors: Zhandong Cai Peiqi Xian Rongbin Lin Yanbo Cheng Tengxiang Lian Qibin Ma Hai Nian...Medicine...
Tue Jan 14, 2020 10:12
The Multifaceted Role of Heme in Cancer: Heme, an iron-containing porphyrin, is of vital importance for cells due to its involvement in several biological processes, including oxygen transport, energy production and drug metabolism. Besides these vital functions, heme also bears toxic properties and, therefore, the amount of heme inside the cells must be tightly regulated. Similarly, heme intake from dietary sources is strictly controlled to meet body requirements. The multifaceted nature of heme...
09:07
miR-20b-5p, TGFBR2, and E2F1 Form a Regulatory Loop to Participate in Epithelial to Mesenchymal Transition in Prostate Cancer: The transcription factor E2F1 regulates the expression of the miR-20b-5p precursor and is involved in epithelial-to-mesenchymal transition (EMT). Transforming growth factor-β1 (TGF-β1) induces EMT in prostate cancer (PCa) by binding to TGF-beta receptor 2 (TGFBR2) to activate TGF-β signaling. However, the relationship between TGFBR2, E2F1, and miR-20b-5p in the modulation...
09:06
Screening and Identifying Immune-Related Cells and Genes in the Tumor Microenvironment of Bladder Urothelial Carcinoma: Based on TCGA Database and Bioinformatics: Bladder cancer is the most common cancer of the urinary system and its treatment has scarcely progressed for nearly 30 years. Advances in checkpoint inhibitor research have seemingly provided a new approach for treatment. However, there have been issues predicting immunotherapeutic biomarkers and identifying new therapeutic targets. We...
09:06
Increased Preoperative Plasma Level of Microbial 16S rDNA Translocation Is Associated With Relapse After Prostatectomy in Prostate Cancer Patients: Background: The environmental factors for promoting prostate cancer (PCa) recurrence remain unknown.Methods: A retrospective cross-sectional study was conducted in healthy men (n = 12) and PCa patients undergoing prostatectomy (n = 27). Plasma preoperative level of total cell-free bacterial 16S rDNA, a marker of microbial translocation, was evaluated...
09:06
Involvement of Glutathione Depletion in Selective Cytotoxicity of Oridonin to p53-Mutant Esophageal Squamous Carcinoma Cells: Oridonin, a diterpenoid compound isolated from traditional Chinese medicine Rabdosia rubescens, has shown antitumor effects to esophageal cancer. However, its molecular mechanism is not fully understood, which limits its clinical application. In the present study, we used RNA-seq analysis to check the transcriptome changes after oridonin treatment and we found genes controlling...
09:06
UBASH3B Is a Novel Prognostic Biomarker and Correlated With Immune Infiltrates in Prostate Cancer: Background: UBASH3B (STS1) is an important gene that negatively regulates T-cell receptor signaling in activated T-lymphocytes that involved in cancers. However, the function of UBASH3B in prostate cancer (PCa) and the correlation between UBASH3B and tumor-infiltrating immune cells still remain unclear.Methods: Real-time PCR and immunohistochemistry were applied to detect mRNA and protein expression...
09:06
Cross-Cancer Pleiotropic Analysis Reveals Novel Susceptibility Loci for Lung Cancer: Genome-wide association studies (GWASs) have identified hundreds of single nucleotide polymorphisms (SNPs) associated with cancer risk, several of which have shown pleiotropic effects across cancers. Therefore, we performed a systematic cross-cancer pleiotropic analysis to detect the effects of GWAS-identified variants from non-lung cancers on lung cancer risk in 12,843 cases and 12,639 controls from four lung cancer...
09:05
Physical exercise effects on metastasis: a systematic review and meta-analysis in animal cancer models: AbstractPhysical exercise is considered a well-tolerated adjuvant therapy to mitigate cancer-related side effects, but its impact on metastasis is unclear. The present systematic review and meta-analysis aimed to summarize the evidence on the effects of exercise on metastasis in animal cancer models. A systematic search was conducted to identify controlled studies in animals analyzing the impact...
09:05
Clinical research tools in pediatric oncology: challenges and opportunities: AbstractSurvival for childhood cancers has improved significantly over the last decades. However, patient outcomes have plateaued over the last decade for difficult-to-treat diseases. With high cure rates, decreasing long-term toxicities and sequelae remains crucial. Since many advances in childhood cancer research come from the adult oncology world, one of the key areas is improving the adaptation of tools that are essential...
09:05
Efficacy of different dosing schedules of capecitabine for metastatic breast cancer: a single-institution experience: SummaryPurpose Capecitabine is widely used as a single agent on a 21-day cycle in the management of metastatic breast cancer (MBC). Our primary objective was to compare the standard dosing of capecitabine (Arm A: days 1–14 on 21-day cycle) to biweekly dosing (Arm B: days 1–7 and 15–21 on 28-day cycle) using retrospective data analysis. Methods 166 patients with MBC treated with single...
09:05
Aspergillus Tracheobronchitis Complicating Bronchial Thermoplasty:
09:04
Frontiers in Physiology | New and Recent ArticlesReactive Jumps Preserve Skeletal Muscle Structure, Phenotype, and Myofiber Oxidative Capacity in Bed RestIdentification of countermeasures able to prevent disuse-induced muscle wasting is crucial to increase performance of crew members during space flight as well as ameliorate patient's clinical outcome after long immobilization periods. We report on the outcome of short but high-impact reactive jumps (JUMP) as countermeasure during 60 days of 6°...
09:03
Introduction of interactive teaching for undergraduate students in community medicineJarina Begum, Syed Irfan Ali, Manasee PandaIndian Journal of Community Medicine 2020 45(1):72-76 Background: There is lack of interest in the subject of community medicine among undergraduate MBBS students leading to poor understanding of community problems and drastic fall in preventive, promotive component of health care. Aim: To evaluate effectiveness of interactive teaching learning (ITL) over traditional teaching...
09:02
Prevalence of maternal measles antibody and its associated factors among infants in Coastal Karnataka, India: S Sathiyanarayanan, Pawan Kumar, Chythra R Rao, Arun Kumar, Asha Kamath, Veena KamathIndian Journal of Community Medicine 2020 45(1):83-88Background: The current recommendation in India to commence first dose of measles immunization is at 9 months of age. The effectiveness of measles vaccination is greatly impacted by the level of maternal measles antibody (MMA) during infancy.Objectives:...
09:00
Major correlates and socioeconomic inequalities in hysterectomy among ever-married women in India: Shri Kant Singh, Santosh Kumar Sharma, Ankita SiddhantaIndian Journal of Community Medicine 2020 45(1):12-17Purpose: This article focuses at the prevalence of hysterectomy, its major correlates, and the socioeconomic inequalities in the prevalence of hysterectomy among women in India. Methods: It used data from 527,865 ever-married women interviewed in 2015–2016 National Family Health Survey-4 from...
09:00
Determinants of sugar-sweetened beverage consumption among indian adults: Findings from the National Family Health Survey-4: Manu Raj Mathur, Deepti Nagrath, Jyotsna Malhotra, Vijay Kumar MishraIndian Journal of Community Medicine 2020 45(1):60-65Background: Sugar-sweetened beverages (SSBs) are associated with obesity, and various other noncommunicable diseases (NCDs). The aim of the study was to study the patterns of consumption of SSBs and association of SSB consumption with various socioeconomic...
09:00
Maternal ability to correctly detect significant jaundice in Indian neonates: Alok Yadav, Amit Devgan, Subhash Chandra Shaw, Puja DudejaIndian Journal of Community Medicine 2020 45(1):8-11Background: The ability of mothers to correctly detect jaundice in their newborns is largely unknown. The objective was to ascertain the ability of mother to correctly detect the presence of significant jaundice in her newborn. Materials and Methods: This cross-sectional study was conducted in a tertiary care hospital...
09:00
Anesthetic Care for the Post-concussive Patient: There Are More Questions Than Answers: AbstractPurpose of ReviewThis review informs the practicing clinician regarding the pathophysiology of mild traumatic brain injury and its implication on the anesthetic management of patients presenting for surgery. It highlights several areas where data is sparse that might spark the interest of researchers. It proposes a broad guideline for managing patients who present for surgery.Recent FindingsThe post-concussive...
08:59
Chest Trauma: Current Recommendations for Rib Fractures, Pneumothorax, and Other Injuries: AbstractPurpose of ReviewThis article provides an overview of the common and important chest injuries that the anesthesiologist may encounter in patients following trauma including blunt injury, pneumothorax, hemothorax, blunt aortic injury, and blunt cardiac injury.Recent FindingsRib fractures are frequently associated with chest injury and are associated with significant pain and other complications. Regional...
08:41
Mixing Insulin • Diabetes Center • PreOp® Patient Education HD: Mixing Insulin • Diabetes Center • PreOp® Patient Education HDhttp://www.PreOp.comYour doctor or diabetes educator may ask you to mix a short-acting or clear insulinwith an intermediate or long acting cloudy insulin in the same syringe so that both can be given at the same time. * The only insulin that cannot be mixed is insulin glargine. * In this example, the doctor has asked you to mix 10 units of regular, clear, insulin with...
08:41
Mechanisms of Pulmonary Toxicity of Perfluoro-n-Alkane Pyrolysis Products with Consideration of the Structural Features of the Blood—Air Barriers: Perfluoroisobutylene a is pulmonotoxic chemical generated during pyrolysis of perfluoro-nalkanes (polytetrafluoroethylene). The mechanisms of acute pulmonary toxicity induced by perfluoroisobutylene have not been studied yet. The analysis of tissues of brown frogs showed that the products of polytetrafluoroethylene pyrolysis induce typical inflammatory...
08:39
Ultrastructure of the Liver in Response to Cyclophosphamide and Triterpenoids: Ultrastructural reorganization of liver cells after isolated injections of cyclophosphamide, betulonic acid or its β-alanylamide, and combined treatment with the cytostatic and each of the triterpenoids is studied. Cyclophosphamide causes significant ultrastructural changes in all intracellular compartments of hepatocytes. Both triterpenoids cause moderate cytotoxic and stimulatory effects on the liver cell populations...
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Method for Determining Microcirculatory Hemodynamics by Laser Speckle Interferometry in Small Animals: We performed experimental evaluation of various positions (ear, paw, and tail) of the of dynamic light scattering sensor of near-infrared laser radiation (840 nm) using speckle interferometry in rats. Dynamic monitoring of the reactions to prolonged ultrasound exposure (7 days) showed that the base of the tail is most suitable for this purpose. Additionally, analysis of microcirculation parameters...
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Specific Roles of JAKs and STAT3 in Functions of Neural Stem Cells and Committed Neuronal Progenitors during Ethanol-Induced Neurodegeneration: Peculiar roles of JAKs and STAT3 in realization of growth potential of various types of progenitor cells in neural tissue were examined during ethanol-induced neurodegeneration modeled both in vitro and in vivo. During in vitro action of C2H5OH, these signal molecules exerted the opposite effects on mitotic activity of multipotent neural stem cells and committed...
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Serum Level of HLDF24 Peptide as an Objective Marker of Prehypertension: The concentrations of the key factors of molecular pathogenesis of prehypertension (angiotensin II, HLDF24, S100b, endothelin, autoantibodies to these molecules, and VEGF) were analyzed in subjects with optimal BP (<120/80 mm Hg) and prehypertension (120-139/80-89 mm Hg). Comparative and correlation analysis of the levels of these molecules was performed. A statistically significant decrease in HLDF24 level in prehypertension...
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Effect of Combined Antimicrobial Therapy on Ischemia/Reperfusion Myocardial Injury in Rats with Acute Inflammation of the Large Intestine against the Background of Alimentary Obesity: We studied the effect of combined antimicrobial therapy with amoxicillin, metronidazole, and clarithromycin on the severity of ischemia/reperfusion myocardial injury in Wistar rats with alimentary obesity and acute inflammation of the large intestine. General ischemia/reperfusion was reproduced on Langendorff-perfused...
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rs11927381 Polymorphism and Type 2 Diabetes Mellitus: Contribution of Smoking to the Realization of Susceptibility to the Disease: In the study that included 579 patients with type 2 diabetes mellitus and 542 healthy individuals from Slavonic population, an association was found between IGF2BP2 gene rs11927381 polymorphism and increased risk of developing the disease. However, this association was observed for smoking patients and was not detected for non-smokers. Bioinformatics analysis showed that...
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Enhanced Expression of TLR8 in Placental Tissue in Preeclampsia: The expression of TLR8 in the placental tissue was studied in specimens from women of reproductive age with early- and late-onset preeclampsia (12 and 8 patients, respectively). The reference groups included 15 women: 10 with uneventful full-term pregnancy and 5 with preterm operative delivery on gestation weeks 28-33. The expression of TLR8 in placental structures was maximum in early-onset preeclampsia (p<0.01) characterized by...
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Analysis of Antitumor Activity of the Liposomal Photosensitizer Lipophthalocyan: We studied specific antitumor activity of a liposomal drug based on tetra-3-phenylthiophthalocyanine aluminum hydroxide (lipophthalocyan) intended for photodynamic therapy. The optimal dose and protocol for photodynamic therapy with lipophthalocyan were chosen in experiments on mice: single intravenous dose of 6 mg/kg with a 5-h interval between administration and laser exposure and irradiation energy density of 400...
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Changes in the Frequency of Rhythmic Excitation of Retzius Cells during Thermal Stimulation of Leech Skin: Thermal stimulation of various parts of the skin in Hirudo medicinalis increases the frequency of spontaneous rhythmic excitation of Retzius neurons in leech ganglia. It was shown that the frequency of spontaneous rhythmic excitation of Retzius cells in the segmental ganglion increases only in response to thermal stimulation and returns to initial values upon cooling. This effect was also detected...
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Assessment of Biocompatibility and Local Action of Biomaterial for Production of an Envelope for Implanted Heart Electronic Devices: We studied a biomaterial for a new domestic product, a biological envelope for implantation of cardiac electronic devices. The product is designed to prevent complications after pacemaker implantation and to facilitate the reimplantation procedure. By chemical and biological processing of raw materials (submucosa of porcine small intestine), an acellular extracellular...
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System of Markers Based on the Methylation of a Group of Proapoptotic Genes in Combination with MicroRNA in the Diagnosis of Breast Cancer: Systems of markers for the diagnosis of breast cancer based on DNA methylation of a group of suppressor protein-coding genes, hypermethylated microRNA genes, and their combinations were compiled. On a representative sample of 70 paired breast cancer specimens (tumor/normal), MS-PCR analysis revealed a significant increase in the methylation frequency of 5 protein-coding...
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Real-Time Recording and Processing of Spike Electrical Activity of the Small Intestine in Experiments on Rats: Real-time recording technique and mathematical processing of the spike electrical activity in the small intestine were developed for chronic experiments on rats. Open-source software was employed to digitize electromyograms and to process them in a real-time mode with a fourth-order nonlinear differential energy operator. This method improved identification of spike electrical activity in...
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Synthesis and Metabolism of Nitric Oxide (NO) in Chicken Embryos and in the Blood of Adult Chicken: In chicken embryos, nitric oxide (NO) is accumulated in the pool of NO donors: S-nitrosothiols, nitrosyl-iron complexes, high-molecular-weight nitro-compounds. Oxidation of NO to nitrate occurs with different intensity in the embryos of different chicken breeds. In some embryos, NO donors accumulate almost without oxidation. Stable concentration of NO donors and nitrate in the blood of adult chicken...
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Serotonin-Containing Cells in the Primary Organ of Hemopoiesis after Autologous Bone Marrow Transplantation: Serotonin-containing cytostructures of mouse bone marrow after autotransplantation were studied using Falk—Hillarp luminescent histochemical method, and expression of antiapoptotic marker was determined by the immunohistochemical reaction. Autotransplantation of the bone marrow in mice led to an increase in the number of mast cells; in 40 and 120 min after autotransplantation, serotonin content...
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Intranasal Administration of Insulin and Gangliosides Improves Spatial Memory in Rats with Neonatal Type 2 Diabetes Mellitus: We analyzed the effects of intranasal administration of insulin (0.48 U/rat) and gangliosides (6 mg/kg) on spatial memory in rats with the neonatal model of the type 2 diabetes mellitus. The development of diabetes was verified by the glucose tolerance test. Insulin and gangliosides improved training and reversal training in diabetic rats in a modified version of Morris water...
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Outcomes After Minimally-invasive Versus Open Pancreatoduodenectomy: A Pan-European Propensity Score Matched Study: Objective: To assess short-term outcomes after minimally invasive (laparoscopic, robot-assisted, and hybrid) pancreatoduodenectomy (MIPD) versus open pancreatoduodenectomy (OPD) among European centers.Background: Current evidence on MIPD is based on national registries or single expert centers. International, matched studies comparing outcomes for MIPD and OPD are lacking.Methods: Retrospective...
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Is There a Role for Liver Transplantation in the Treatment of Patients With Metastatic Colorectal Cancer?:
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Betulinic acid induces apoptosis of gallbladder cancer cells via repressing SCD1: AbstractGallbladder cancer (GBC) is the most common and aggressive malignancy of the biliary tract. Betulinic acid (BetA) has been reported to have anti-inflammatory and antitumor effects; however, the effect of BetA on GBC is still unknown. In this study, we investigated the effect of BetA on five GBC cell lines and found that BetA significantly inhibited the proliferation of NOZ cells but had little inhibitory effect...
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Long noncoding RNA UC.98 stabilizes atherosclerotic plaques by promoting the proliferation and adhesive capacity in murine aortic endothelial cells: AbstractPathological studies have shown that the vulnerability of plaques affects outcomes in patients with atherosclerosis (AS), a chronic inflammatory disease and common cause of morbidity and mortality worldwide. Although emerging technologies have enabled early diagnosis of AS with high-risk vulnerable plaques, more accurate and noninvasive diagnostic...
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Enhanced store-operated calcium entry in platelets is associated with acute coronary syndrome: Acute coronary syndrome (ACS) is associated with sudden, reduced blood flow to the heart and usually correlated with coronary thrombosis [1]. Therefore, platelets play an important part in the pathogenesis and complications of ACS. Platelet activation is a complex event involving activation of intracellular signaling cascades, such as calcium signaling, which leads to platelet activation, secretion and...
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MiR-155 aggravates impaired autophagy of pancreatic acinar cells through targeting Rictor: AbstractThe aim of this study was to investigate the role and mechanism of miR-155 in regulating autophagy in a caerulein-induced acute pancreatitis (AP) cellular model. GFP-LC3 immunofluorescence assay was performed to detect autophagy vesicle formation in pancreatic acinar cell line AR42J. AR42J cells were transfected with miR-155 mimic, inhibitor, and corresponding controls to explore the effect of miR-155...
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Downregulating integrin subunit alpha 7 (ITGA7) promotes proliferation, invasion, and migration of papillary thyroid carcinoma cells through regulating epithelial-to-mesenchymal transition: AbstractThyroid cancer is one of the common malignancies of the endocrine system and the number of thyroid cancer cases is increasing constantly. Significant work has focused on the molecular mechanisms of thyroid cancer, but many mechanisms remain undiscovered. In this study, we employed a comprehensive analysis...
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A rare case of a pediatric white epidermoid cyst: AbstractWhite epidermoid cysts are a rare entity that present with atypical signal characteristics on MRI in comparison to typical epidermoid cysts. This can mislead a practitioner when trying to formulate a differential diagnosis based on imaging. We present the case of 15-year-old girl who presented with a pontine-medullar junction mass. This mass did not follow typical signal characteristics for known lesions. The mass was ultimately found to be...
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The rolling cyst: migrating intraventricular neurocysticercosis—a case-based update: AbstractBackgroundNeurocysticercosis is the most frequent parasitic disease of the central nervous system, and its incidence in the developed countries is increasing due to immigration and travels from endemic areas. The intraventricular location has been found to involve up to 61.3% of the patients; moreover, only 22 cases of migrating intraventricular cyst have been reported so far. Despite the rarity of the condition...
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Antioxidants, Vol. 9, Pages 73: Tomato as Potential Source of Natural Additives for Meat Industry. A Review: Antioxidants, Vol. 9, Pages 73: Tomato as Potential Source of Natural Additives for Meat Industry. A ReviewAntioxidants doi: 10.3390/antiox9010073Authors: Rubén Domínguez Patricia Gullón Mirian Pateiro Paulo E. S. Munekata Wangang Zhang José Manuel Lorenzo Tomato industry produces huge amounts of by-products that represent an environmental and economic problem. However, these by-products...
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