Lippincott's Tuesday - 35 Journals - Thank you !
New Recommendations on Sport-Related Concussions: Stronger Methodology, Practical Messages, and Remaining ChallengesNo abstract availableRelative Head Impact Exposure and Brain White Matter Alterations After a Single Season of Competitive Football: A Pilot Comparison of Youth Versus High School FootballObjective: Youth athletes are believed to be more susceptible to white matter (WM) degradation resulting from head impact exposure relative to high school (HS) athletes; this hypothesis has not been...
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The concept of peri-operative medicine to prevent major adverse events and improve outcome in surgical patients: A narrative reviewPeri-operative Medicine is the patient-centred and value-based multidisciplinary peri-operative care of surgical patients. Peri-operative stress, that is the collective response to stimuli occurring before, during and after surgery, is, together with pre-existing comorbidities, the pathophysiological basis of major adverse events. The ultimate goal of Peri-operative Medicine...
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Lithium-Induced Neurotoxicity: A Case StudyBACKGROUND In patients presenting with neurological deficits, identifying the cause can be challenging. METHODS This case study discusses a condition that is not commonly seen. DISCUSSION Although lithium toxicity syndrome is not as familiar as other causes of neurological issues, this should be considered for any patient who presents with unexplained neurological deficits and a history of taking this medication. CONCLUSION If toxicity is not recognized...
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Effects of mineralocorticoid receptor antagonists in proteinuric kidney disease: a systematic review and meta-analysis of randomized controlled trialsBackground: Reductions in albuminuria of more than 30% are considered a strong marker of delay of chronic kidney disease (CKD) progression. Single renin–angiotensin system (RAS) blockade represents the cornerstone of CKD treatment. However, as CKD progression still occurs, other nephroprotective options were explored; mineralocorticoid receptor antagonists...
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A time for reflection and growthNo abstract availableBuilding a continuous renal replacement therapy program in a community hospitalAbstract: Continuous renal replacement therapy (CRRT) is a high-risk therapy used to treat acute kidney injury. Community hospitals lack the patient volume to adequately develop staff CRRT competency. This article will cover lessons learned developing a CRRT program at a small community hospital with low patient census requiring CRRT.Minimal change disease: A case reportAbstract:...
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Anaerobic resistance: should we be worried?Purpose of review Anaerobic bacteria are implicated in a broad range of infections and can cause significant morbidity and mortality. As such, development of antimicrobial resistance (AMR) increases the risk of worse clinical outcomes and death. Recent findings Anaerobe AMR is highly variable according to region and species included in the survey. The overall trend is to increasing resistance, particularly in Europe and Asia, and in the Bacteroides fragilis...
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Acute kidney injury in hematopoietic stem cell transplantationPurpose of review Acute kidney injury (AKI) in the setting of hematopoietic stem cell transplantation (HSCT) is common in pediatric and adult patients. The incidence ranges from 12 to 66%, and development of AKI in the posttransplant course is independently associated with higher mortality. Recent findings Patients who undergo HSCT have many risk factors for developing AKI, including sepsis, use of nephrotoxic medications, graft versus...
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Stroke in Ventricular Assist Device Patients: Reducing Complications and Improving OutcomesNo abstract availableExtracorporeal Membrane Oxygenation for Adults With Refractory Septic ShockBecause of a severe dysregulation of the host response to infection, septic shock may induce a profound imbalance between oxygen consumption and delivery, which in some cases may be refractory to conventional support measures. In this setting, extracorporeal membrane oxygenation (ECMO) may help to restore this ratio....
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Overall survival after treatment for metastatic uveal melanoma: a systematic review and meta-analysisThe overall survival (OS) of patients with metastatic uveal melanoma is short, the evidence for effectiveness of treatments is limited, and no consensus on the choice of treatment exists. We aimed to advance interpretation of OS as an outcome by pooling peer-reviewed data. The design is a systematic review and meta-analysis. We searched PubMed from 1 January 1980, to 29 March 2017, for articles reporting...
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Sodas and colas are associated with an increase in fracturesNo abstract availableMenopause and high-intensity interval training: effects on body composition and physical performanceNo abstract availableAssociation between soft drink consumption and osteoporotic fractures among postmenopausal women: the Women's Health InitiativeObjective: High consumption of soft drinks has been associated with lower bone mineral density among postmenopausal women. This study explores the association of soft drink...
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Current Opinion in Anesthesiology: : new editor announcementNo abstract availableRecovery and discharge criteria after ambulatory anesthesia: can we improve them?Purpose of review Day surgery coming and leaving hospital day of surgery is growing. From minor and intermediate procedure performed on health patient, day surgery is today performed on complex procedures and elderly patient and on patients with comorbidities. Thus, appropriate discharge assessment is of huge importance to secure safety...
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Endophenotypes of executive functions in obsessive compulsive disorder? A meta-analysis in unaffected relativesEndophenotypes are mediator traits between genetic influences and clinical phenotypes. Meta-analyses have consistently shown modest impairments of executive functioning in obsessive compulsive disorder (OCD) patients compared to healthy controls. Similar deficits have also been reported in unaffected relatives of OCD patients, but have not been quantified. We conducted the first meta-analysis...
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Silent Illumination: A Case Study Exploring the Spiritual Needs of a Transgender-Identified Elder Receiving Hospice CareWith a growing population of transgender-identified elders in the United States, their unique spiritual end-of-life needs are coming to light. This article presents a case study of a hospice volunteer who used skillful means as an artist to help a transgender-identified woman express her spirituality in the last 6 months of her life. After data analysis, 4 themes emerged related...
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Pharmacogeomic implications of population diversity in Latin America: TPMT: and: NUDT15: polymorphisms and thiopurine dosingTPMT and NUDT15 polymorphisms are major determinants of tolerance to thiopurine drugs used in leukemias and nonmalignant immunologic disorders. We adopted an extreme discordant phenotype approach to explore the impact of Native American versus European ancestry on the distribution of TPMT and NUDT15 polymorphisms, and inferred metabolic phenotypes in the 1000 Genomes Ad Mixed...
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New targets, treatments and trials for preventing and reversing atherosclerosis: the paradox of choiceNo abstract availableSPPARM alpha: the Lazarus effectPurpose of review Atherogenic dyslipidaemia, characterized by high plasma triglycerides (a surrogate for triglyceride-rich remnant lipoproteins) and low high-density lipoprotein cholesterol (HDL-C), is prevalent in patients with type 2 diabetes mellitus (T2DM) and contributes to a high modifiable residual cardiovascular risk. Fibrates are effective...
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Predictive criteria for acute heart failure in emergency department patients with acute dyspnoea:...
Predictive criteria for acute heart failure in emergency department patients with acute dyspnoea: the PREDICA studyObjectives The early identification of patients with Acute Heart Failure Syndrome (AHFS) among patients admitted to the Emergency Department (ED) with dyspnoea can facilitate the introduction of appropriate treatments. The objectives are to identify the predictive factors for AHFS diagnosis in patients with acute dyspnoea (primary objective) and the clinical 'gestalt' (secondary objective)...
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Contributors: Clinical Dilemmas and Unresolved Issues in GynecologyNo abstract availableForeword: Clinical Dilemmas and Unresolved Issues in GynecologyNo abstract availableBreast Cancer and the Obstetrician-Gynecologist: A Focus on Screening, Risk Assessment and Treatment of Survivors With Genitourinary Syndrome of MenopauseBecause of conflicting guidelines, providing appropriate breast cancer screening recommendations to our patients has become challenging. Given the high prevalence of genitourinary...
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When rubber meets the road: how innate features of adaptive immune cells play critical roles in transplant alloimmunityPurpose of review Studies on adaptive cells have largely focused on features that are specific to adaptive immunity. However, adaptive cells utilize innate cell features to modulate their responses, and this area of T and B-cell biology is understudied. This review will highlight recent work done to understand how innate features of adaptive immune cells modulate alloimmunity. Recent...
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Methodology and Demographics of a Brief Adolescent Alcohol Screen Validation StudyObjective The aim of this study was to determine the psychometric properties of the National Institute on Alcohol Abuse and Alcoholism (NIAAA) 2-question alcohol screen within 16 Pediatric Emergency Care Applied Research Network pediatric emergency departments. This article describes the study methodology, sample characteristics, and baseline outcomes of the NIAAA 2-question screen. Methods Participants included 12-...
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Merging therapeutics and supportive care: synergy and yieldNo abstract availableSarcopenia: looking to muscle mass to better manage pancreatic cancer patientsPurpose of review Overall survival of patients with pancreatic cancer is strongly conditioned by tumor biology and the incidence of malnutrition and metabolic disorders. In this landscape, the assessment of body composition is crucial to properly manage the clinical implications of muscle wasting. The pathogenesis of this condition is the result...
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The voluminous axon as an organizing principle for traumatic brain injury therapeutics: novel molecular, metabolic, and circuit strategiesNo abstract availableWallerian degeneration as a therapeutic target in traumatic brain injuryPurpose of review Diffuse or traumatic axonal injury is one of the principal pathologies encountered in traumatic brain injury (TBI) and the resulting axonal loss, disconnection, and brain atrophy contribute significantly to clinical morbidity and disability. The seminal...
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Rheumatologic and autoimmune manifestations in primary immune deficiencyPurpose of review Here we review the rheumatologic and autoimmune features of primary immune deficiencies with a focus on recently recognized genetic diseases, the spectrum of autoimmunity in PID, and targeted therapies. Recent findings Primary immune deficiencies (PIDs) were initially described as genetic diseases of the immune system leading to susceptibility to infection. It is now well recognized that immune dysfunction and...
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Detection and management of atypical femur fracturesPurpose of review This article summarizes the risk factors for atypical femur fractures (AFF), discusses current and emerging imaging modalities for early identification of AFF, and offers recommendations for prevention and management of AFFs based on the current concepts. Recent findings Antiresorptive therapies are widely recommended for prevention and treatment of osteoporosis. Despite their well established effectiveness to reduce fracture risk,...
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Getting to zero: Patient safety, leadership, and youNo abstract availableCultivating a culture of innovationNo abstract availableImplementation of chlorhexidine gluconate bathing to reduce HAIsA nurse leader-led evidence-based practice changeEnteral tubing connection changes: A failure modes and effects analysisNo abstract availableUtilizing the IDEAL discharge process to prevent 30-day readmissionsNo abstract availableNew medication adverse reaction educationIncreasing patient satisfaction scoresClinical...
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Predictors of Distant Metastasis and Survival in Adenoid Cystic Carcinoma of the External Auditory CanalObjective: To analyze the predictors of both distant metastasis and survival in patients with adenoid cystic carcinoma of the external auditory canal. Study Design: Retrospective patient review. Setting: A single university hospital. Patients: Eighty-two cases with adenoid cystic carcinoma of the external auditory canal were referred to our institution between 2004 and 2016. Main Outcome Measures:...
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Desmopressin Is A Transfusion Sparing Option To Reverse Platelet Dysfunction In Patients With Severe Traumatic Brain InjuryBackground Platelet dysfunction (PD) is an independent predictor of mortality in patients with severe traumatic brain injury (sTBI). Platelet transfusions have been shown to be an effective treatment strategy to reverse platelet inhibition. Their use is contingent on availability and may be associated with increased cost and transfusion related complications making desmopressin...
07:49
Assessment of Anesthesia Practice Patterns for Endovascular Therapy for Acute Ischemic Stroke: A Society for Neuroscience in Anesthesiology and Critical Care (SNACC) Member SurveyBackground: The choice of general anesthesia (GA) or conscious sedation (CS) may impact neurological outcomes of patients undergoing endovascular therapy (EVT) for acute ischemic stroke (AIS). The aim of this survey was to describe the practice patterns of members of the Society for Neuroscience in Anesthesiology and Critical...
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Evidence of Vowel Discrimination Provided by the Acoustic Change ComplexObjectives: The objectives of this study were to measure the effects of level and vowel contrast on the latencies and amplitudes of acoustic change complex (ACC) in the mature auditory system. This was done to establish how the ACC in healthy young adults is affected by these stimulus parameters that could then be used to inform translation of the ACC into a clinical measure for the pediatric population. Another aim was to demonstrate...
07:47
Evidence of Vowel Discrimination Provided by the Acoustic Change ComplexObjectives: The objectives of this study were to measure the effects of level and vowel contrast on the latencies and amplitudes of acoustic change complex (ACC) in the mature auditory system. This was done to establish how the ACC in healthy young adults is affected by these stimulus parameters that could then be used to inform translation of the ACC into a clinical measure for the pediatric population. Another aim was to demonstrate...
07:46
Epithelial dysfunction in chronic respiratory diseases, a shared endotype?Purpose of review Epithelial barrier defects are being appreciated in various inflammatory disorders; however, causal underlying mechanisms are lacking. In this review, we describe the disruption of the airway epithelium with regard to upper and lower airway diseases, the role of epigenetic alterations underlying this process, and potential novel ways of interfering with dysfunctional epithelial barriers as a novel therapeutic...
07:45
Nurses' Use and Ways of Understanding Web-Based National Guidelines for Child HealthcareThe national Rikshandboken for child healthcare is both a Web-based guideline containing knowledge and methodological guidance and a national child healthcare program in the process of being implemented in Sweden. The aim of this study was to examine child healthcare nurses' use and ways of understanding the national Web-based Rikshandboken. A mixed-methods study with sequential explanatory design in two phases...
07:44
Neurovascular effects of perivascular adipose tissue Regulation of sympathetic-sensory communicationNo abstract availableChitosan Hydrogel Enhances the Therapeutic Efficacy of BMSCs for Myocardial Infarction by Alleviating Vascular Endothelial Cell PyroptosisMyocardial infarction (MI) is one of the higher mortality rates, and current treatment can only delay the progression of the disease. Experiments have shown that cell therapy could improve cardiac function and mesenchymal stem cells (MSCs)-based...
07:43
Accuracy testing of a new optical device for noninvasive estimation of systolic and diastolic blood pressure compared to intra-arterial measurementsObjective The objective of this study was to compare the systolic (S) and diastolic (D) blood pressure (BP) estimations from a new optical device at the wrist with invasive measurements performed on patients scheduled for radial arterial catheterization in the ICU. Optical signals were automatically processed by a library of algorithms from Aktiia SA...
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Disparities in Health Care for Hispanic Patients in Physical Medicine and Rehabilitation in the United States: A Narrative ReviewIn the United States, the number of people with Hispanic backgrounds is rapidly increasing. This growth, along with other factors, may put them at increased risk for healthcare disparities. Thus, Physical Medicine and Rehabilitation (PM&R) should evaluate disparities in health services through the lens of the evidence base. To our knowledge, this is the first review...
07:42
A Joint Power Approach to Define Countermovement Jump Phases Using Force PlatformsConflicting methodologies are used to define certain countermovement vertical jump (CMVJ) phases, which limits identification of performance-enhancing factors (e.g., rate of force development). Purpose We (a) utilized a joint power approach to define CMVJ phases that accurately describe body weight unloading (i.e., unweighting) and eccentric (i.e., braking) actions, which were combined with the robustly-defined concentric...
07:41
A Time to Eat and A Time to ExerciseThis Perspectives for Progress provide a synopsis for the potential of time-restricted eating (TRE) to rescue some of the deleterious effects on circadian biology induced by our modern-day lifestyle. We provide novel insights into the comparative and potential complementary effects of TRE and exercise training on metabolic health. Corresponding Author: John A. Hawley, Ph.D. Exercise and Nutrition Research Program Mary MacKillop Institute for Health Research Australian...
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