Host-Response Subphenotypes Offer Prognostic Enrichment in Patients With or at Risk for Acute Respiratory Distress SyndromeObjectives: Classification of patients with acute respiratory distress syndrome into hyper- and hypoinflammatory subphenotypes using plasma biomarkers may facilitate more effective targeted therapy. We examined whether established subphenotypes are present not only in patients with acute respiratory distress syndrome but also in patients at risk for acute respiratory distress...
09:48
Vitamin D Deficiency: Beyond Sunshine!Hussein F Saadi, Juma M AlkaabiIbnosina Journal of Medicine and Biomedical Sciences 2019 11(3):95-96Paradoxical Vitamin D deficiency in a sunny country: A narrative review of the literature from the United Arab Emirates (1992–2018)Salem A Beshyah, Khadija Hafidh, Dima K Abdelmannan, Abdul Jabbar, Wafic S Wafa, Aly B KhalilIbnosina Journal of Medicine and Biomedical Sciences 2019 11(3):97-108Deficiency of Vitamin D is a global problem related to lack of sunlight...
09:48
Factors associated with gains in performance during rehabilitation following pediatric brain injury: growth curve analysisObjective Predicting recovery of functional performance within pediatric rehabilitation following brain injury is important for health professionals and families, but information regarding factors associated with change in functional skills ("what the child can do") and functional independence ("what the child does") is limited. This study examined change in functional skills...
09:47
Decreased growth among antiretroviral drug and HIV exposed uninfected versus unexposed children in Malawi and UgandaObjective: To compare growth among antiretroviral drug and maternal-HIV exposed uninfected (AHEU) versus age-and-sex-matched HIV unexposed uninfected (HUU) children. Design: Prospective cohort of AHEU children identified from the PROMISE trial (NCT01061151: clinicaltrials.gov registry) and age-and-sex-matched HUU controls from child-wellness clinics, enrolled (09/2013–10/2014) in Malawi...
09:47
Immediate deltopectoral flap salvage of a failing anterolateral thigh free flapAuthor links open overlay panelBipin T.VargheseSowrabhAroraHead and Neck Surgery Unit, Surgical Services, Regional Cancer Centre, Trivandrum, Kerala 695011, IndiaReceived 24 September 2019, Revised 8 October 2019, Accepted 14 October 2019, Available online 21 October 2019.Figures (2)https://doi.org/10.1016/j.oraloncology.2019.104451Get rights and contentHighlight•DP flap salvage with accelerated delay and utilisation of...
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Amh regulate female folliculogenesis and fertility in a dose-dependent manner through Amhr2 in Nile tilapiaPublication date: 1 January 2020Source: Molecular and Cellular Endocrinology, Volume 499Author(s): Xingyong Liu, Hesheng Xiao, Mimi Jie, Shengfei Dai, Xin Wu, Minghui Li, Deshou WangAbstractIn the present study, Amh was found to be abundantly expressed in the granulosa cells of the primary growth follicles, and Amhr2 in the granulosa cells, oogonia and phase I oocytes in tilapia by immunohistochemistry....
09:46
Reduced Foxo3a, FoxL2, and p27 mRNA expression in human ovarian tissue in premature ovarian insufficiencyAbstractPurposePrevious studies have suggested that deletion of Foxo3a, FoxL2, PTEN, p27, and AMH leads to early exhaustion of the primordial follicle pool and premature ovarian insufficiency (POI) in transgenic mice. Our aim was to assess for the first time, to our knowledge, messenger RNA (mRNA) expression of these genes and AMHR2 in human ovarian tissue from women with POI. We hypothesized...
09:43
Body-mounted robotic assistant for MRI-guided low back pain injectionAbstractPurposeThis paper presents the development of a body-mounted robotic assistant for magnetic resonance imaging (MRI)-guided low back pain injection. Our goal was to eliminate the radiation exposure of traditional X-ray guided procedures while enabling the exquisite image quality available under MRI. The robot is designed with a compact and lightweight profile that can be mounted directly on the patient's lower back via straps,...
09:43
Bariatric Surgery in Children and Adolescents with Cognitive Impairment and/or Developmental Delay: Current Knowledge and Clinical RecommendationsAbstractBariatric surgery is an effective treatment for children and adolescents with severe obesity. However, outcomes in youth with cognitive impairments and/or developmental delays are understudied. This paper reviewed the literature on bariatric surgery within this population. Fourteen studies published from 1975 to 2019 were identified. The majority...
09:43
Deactivation and mislocalization of Toxoplasma gondii rhoptry protein 18 induced by a single amino acid mutation on the proton transport catalytic aspartic acidPublication date: January 2020Source: Microbiological Research, Volume 230Author(s): Yang Zhang, Bo Shiun Lai, Mario JuhasAbstractRhoptry protein 18 (ROP18) is a major determinant of strain-specific virulence in Toxoplasma gondii. The kinase activity of ROP18 is required for acute virulence, while the aspartate in the catalytic loop of ROP18...
09:42
Addition of Bevacizumab to First-Line Palliative Chemotherapy in Patients with Metastatic Small Bowel Adenocarcinoma: A Population-Based StudyAbstractBackgroundData about the use and effectiveness of targeted therapy in metastatic small bowel adenocarcinoma (SBA) are scarce.ObjectiveThe aim of this population-based study was to obtain insights into the use and effectiveness of targeted therapy in patients with synchronous metastases of SBA.Patients and methodsData were retrieved from the Netherlands...
09:42
Prospective randomized comparison of early versus newer-generation vertebral access devices for kyphoplastyAbstractIntroductionKyphoplasty is an established method of treating osteoporotic vertebral body compression fractures. In recent years, several techniques to enhance the efficiency and outcomes of this surgery have been developed and implemented in clinical practice. In the present study, we assess the impact of two new access instruments on overall operation time and the administered dose...
09:41
Serum lipidome screening in patients with stage I non-small cell lung cancerAbstractThe ability of early lung cancer diagnosis is an unmet need in clinical practice. Lung cancer metabolomic analyses conducted so far have demonstrated several abnormalities in cancer lipid profile providing a rationale for further study of blood lipidome of the patients. In the present research, we performed a targeted lipidome screening to select molecules that show promise for early lung cancer detection. The study...
09:41
Regional prescription surveillance of phosphate binders in the western Saitama area: the substantial role of ferric citrate hydrate in improving serum phosphorus levels and erythropoiesisIn the Original publication, Under the table 1, the number of participants in the April has been incorrectly published as 1373. The corrected table is given below.ADPKD and metformin: from bench to bedsideRisk factors and incidence of malignant neoplasms after kidney transplantation at a single institution in JapanAbstractBackgroundThe...
09:41
Endoscopic-assisted surgical repair of superior canal dehiscence using a keyhole middle fossa craniotomy approachPublication date: Available online 27 September 2019Source: Operative Techniques in Otolaryngology-Head and Neck SurgeryAuthor(s): Elliott D. Kozin, Daniel J. LeeSuperior canal dehiscence (SCD) is a bony defect of the superior semicircular canal that is called SCD syndrome (SCDS) when associated with vestibular and auditory dysfunction. Surgical management of SCD is reserved for patients...
09:40
Amh regulate female folliculogenesis and fertility in a dose-dependent manner through Amhr2 in Nile tilapiaPublication date: 1 January 2020Source: Molecular and Cellular Endocrinology, Volume 499Author(s): Xingyong Liu, Hesheng Xiao, Mimi Jie, Shengfei Dai, Xin Wu, Minghui Li, Deshou WangAbstractIn the present study, Amh was found to be abundantly expressed in the granulosa cells of the primary growth follicles, and Amhr2 in the granulosa cells, oogonia and phase I oocytes in tilapia by immunohistochemistry....
09:39
Inducing transient mixed chimerism for allograft survival without maintenance immunosuppression with combined kidney and bone marrow transplantation: Protocol OptimizationBackground. Tolerance induction is an important goal in the field of organ transplantation. We have sequentially modified our conditioning regimen for induction of donor-specific tolerance in recipients of major histocompatibility complex (MHC)-mismatched combined kidney and bone marrow transplantation (CKBMT). Methods. From December...
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Pediatric Chronic Critical Illness: Gaps in Inpatient Intrateam CommunicationObjectives: The number of children with medical complexity and prolonged hospitalizations is rising. Strategies to adapt acute care approaches for this population are falling behind clinical demand. This study aimed to identify how inpatient team communication practices match the needs of teams caring for these patients and families, and to identify priority areas for improvement. Design: Cross-sectional mixed methods survey....
09:38
Auditory Characteristics in Patients With MucopolysaccharidosisObjective: The purpose of the study was to evaluate audiologic findings according to mucopolysaccharidosis (MPS) subtypes and to estimate hearing changes as the disease progressed, as well as the therapeutic effect of enzyme replacement therapy on the hearing apparatus. Methods: A total of 124 patients who were diagnosed with MPS between September 1994 and December 2016 were retrospectively analyzed. Play audiometry or pure-tone audiometry...
09:38
Long-term Outcomes of Injection Drug-related Infective Endocarditis Among People Who Inject DrugsObjectives: Infective endocarditis (IE) among people who inject drugs is associated with high rates of mortality and repeat episodes of endocarditis. We sought to report on longer-term clinical outcomes of patients with IE who were offered buprenorphine or methadone treatment for opioid use disorder (OUD) at their initial hospital admission. Methods: Individuals with OUD hospitalized between 2013 and...
09:38
The Possible Role of Color Doppler and Pulse Wave Doppler Ultrasound in the Diagnosis of Cutaneous Lymphangioma CircumscriptumCutaneous lymphangioma circumscriptum (CLC) is an uncommon congenital lymphatic malformation. Its dermoscopic features have been reported, however, if blood has infiltrated the lacunas, a pink hue overwhelms the lacunar structures, rendering dermoscopic features indistinguishable. In addition, dermoscopy cannot assess the subcutaneous extent of the lesion before surgery. The...
09:37
Assessing the Effect of Middle Ear Effusions on Wideband Acoustic Immittance Using Optical Coherence TomographyObjectives: Wideband acoustic immittance (WAI) noninvasively assesses middle ear function by measuring the sound conduction over a range of audible frequencies. Although several studies have shown the potential of WAI for detecting the presence of middle ear effusions (MEEs), determining the effects of MEE type and amount on WAI in vivo has been challenging due to the anatomical location...
09:37
Expanding the indications for autologous stem cell transplantation: do we need a new approach to supportive care for patients with multiple sclerosis?No abstract availableMeaningful measures in cancer cachexia: implications for practice and researchPurpose of review Cancer cachexia is a complex inflammatory syndrome, which presents with a variety of discrete symptoms and signs. This creates a challenge for both clinicians and researchers in recognizing and assessing the syndrome. This review explores...
09:36
Moving boundaries in anaesthesiologyNo abstract availableHow to optimize neuromuscular blockade in ambulatory setting?Purpose of review The purpose of this review is to discuss the optimal use of neuromuscular blocking agents (NMBA) during ambulatory surgery, and to provide an update on the routine use of neuromuscular monitoring and the prevention of residual paralysis. Recent findings The number of major surgical procedures performed in ambulatory patients is likely to increase in the coming years,...
09:36
Impact of a Prescription Drug Monitoring Program on Health Information Exchange Utilization, Prescribing Behaviors, and Care Coordination in an Emergency DepartmentTimely access to patient data is critical in patient care. The utilization of health information exchange and prescription drug monitoring programs can make pertinent data readily accessible for emergency department providers to coordinate care. A quasi-experimental preintervention-postintervention design, with 62 providers and 53 554...
09:35
Host-Response Subphenotypes Offer Prognostic Enrichment in Patients With or at Risk for Acute Respiratory Distress SyndromeObjectives: Classification of patients with acute respiratory distress syndrome into hyper- and hypoinflammatory subphenotypes using plasma biomarkers may facilitate more effective targeted therapy. We examined whether established subphenotypes are present not only in patients with acute respiratory distress syndrome but also in patients at risk for acute respiratory distress...
09:35
Precision medicine: PI3K targeting in advanced breast cancerCorrection to: Non-contrast MRI for breast screening: preliminary study on detectability of benign and malignant lesions in women with dense breastsIn the original version of the article, the image of Figure 2 was erroneously duplicated as Figure 4. The correct version of Figure 4 is given below. The original article has been corrected.Letter regarding Sopik V et al. entitled "Impact of microinvasion on breast cancer mortality in women with...
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Manage postpartum depression with psychosocial strategies, psychotherapy and/or pharmacotherapy based on its severityAbstractPostpartum depression (PPD) is more intense than the 'baby blues', and may last for months to years without treatment. PPD may have significant, as well as devastating, consequences, but is often under-detected and under-treated. Screening questions and questionnaires can be used to identify patients with PPD, and psychosocial strategies (e.g. peer support, professional counselling),...
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Divorce, Disorientation, and RemarriageAbstractThis paper asks three inter-related questions, proceeding chronologically through a divorcee's experience: (i) is it responsible and rational to make an unconditional marital vow in the first place? (ii) does divorce break that unconditional marital vow? And the main question: (iii) can the divorcee make a second unconditional marital vow in all moral seriousness? To the last question I answer yes. I argue that the divorce process is so disorienting...
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Anmerkung zu BGH, Urt. v. 4.4.2019 – III ZR 35/18 (OLG Frankfurt a.M.)Nicola Hegerfeld, Ärztliche Aufklärungs- und Informationspflichten. Eine Auseinandersetzung mit der Qualität der Kodifizierung der §§ 630e und 630c BGB, Bd. 81.Kristin Koch, Der Eid des Hippokrates gestern und heute – sein Einfluss auf das moderne Medizinstrafrecht. Ein Weg von "salus aegroti suprema lex" zu "voluntas aegroti suprema lex".Anmerkung zu BSG, Urt. v. 12.12.2018 – B 6 KA 55/17 R (SG Marburg)Zur Steuerbefreiung von...
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NavWell: A simplified virtual-reality platform for spatial navigation and memory experimentsAbstractBeing able to navigate, recall important locations, and find the way home are critical skills, essential for survival for both humans and animals. These skills can be examined in the laboratory using the Morris water maze, often considered the gold standard test of animal navigation. In this task, animals are required to locate and recall the location of an escape platform hidden in a pool filled with...
08:38
MDMA Induced Cardio-toxicity and Pathological Myocardial Effects: A Systematic Review of Experimental Data and Autopsy FindingsAbstract3,4-Methylenedioxymethamphetamine (MDMA), more commonly known as "ecstasy," is a semi-synthetic entactogenic phenylethylamine. In recent years it has gained popularity as a recreational drug whose use has registered an upward trend especially among adolescents and young adults. Despite its unwarranted reputation of being a "safe" drug, the actual scientific data denote...
08:38
Intravesical invasion of a Mersilene tape and secondary stone formationLetter to the editor: does estrogen deprivation affect pelvic floor muscle contractility?Commentary on: Outpatient visits versus telephone interviews for postoperative care: a randomized controlled trialCommentary on "Risk factors and outcome of repair of obstetric anal sphincter injuries as followed up in a dedicated perineal clinic"Use of multimedia during informed consent: novelty or necessityAbstractThe process of informed...
08:37
The Role of Safety Behaviors in Panic Disorder Treatment: Self-Regulation or Self-Defeat?AbstractSafety behaviors (SBs) are generally perceived as 'dysfunctional' emotion-regulation strategies that reduce physical symptoms and prevent unrealistic feared consequences of panic attacks. However, it is unclear whether all types of SBs are a hindrance or whether some may promote self-regulation in treatment. We propose that the type of SBs might explain some of the variability between panic disorder (PD)...
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Improved Reduction of the Tibiofibular Syndesmosis With TightRope Compared With Screw Fixation: Results of a Randomized Controlled StudyObjective: To compare the rate of malreduction after high fibular fractures associated with syndesmosis injury treated with open reduction and internal fixation, with either 2 screws or 1 knotless TightRope device. Design: Prospective randomized controlled multicenter trial. Setting: Eleven academic and community hospitals including Level 1 and Level 2 trauma centers...
08:36
Adverse Childhood Experiences and Family Resilience Among Children with Autism Spectrum Disorder and Attention-Deficit/Hyperactivity DisorderABSTRACT: Objectives: The purpose of the present study was to (1) examine the differences in adverse childhood experiences (ACEs) among children with autism spectrum disorder (ASD), attention-deficit/hyperactivity disorder (ADHD), and comorbid ASD/ADHD and healthy neurodevelopmental controls; (2) explore the levels of family resilience across diagnostic categories;...
08:35
What'd New in Shock, November 2019?No abstract availableComparison Between Continuous and Intermittent Administration of Hydrocortisone During Septic Shock: A Randomized Controlled Clinical TrialObjectives: The best modality of administration of hydrocortisone during septic shock has been poorly evaluated and the guidelines remain unclear in this respect. This study aimed to compare bolus of hydrocortisone to a continuous infusion during septic shock. Design: Randomized controlled, open-label trial....
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Neoadjuvant Chemo to Refine Risk in HER2-Positive Breast CancerNo abstract availableHow Light Therapy Can Help With Oral Mucositis ManagementNo abstract availableResearcher Urges Caution in Use of Surrogate Endpoints in Clinical TrialsNo abstract availableUpToDate®No abstract availableLarotrectinib (Vitrakvi®)No abstract availableTracking Cellular Changes Associated With Cancer Through DataNo abstract availableOncology Care Model Supports Practice & Benefits Medicare's Bottom LineNo abstract...
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Bringing new technology and evidence into cardiovascular practice: the utility of translational scienceNo abstract availableSlaying the dragons: rehabilitating emergency services personnelNo abstract availableElectronic textile-based electrocardiogram monitoring in cardiac patients: a scoping reviewObjective: The objectives of this scoping review were to explore, organize and present the existing research literature on the use of electronic textile (e-textile)-based resting, signal-averaged, ambulatory...
08:34
Thoughts on NursingNo abstract availableLooking to the Future!No abstract availableTransitions and WelcomesNo abstract availableAdverse Childhood Event Scores Associated With Likelihood of Missing Appointments and Unsuppressed HIV in a Southeastern U.S. Urban Clinic SampleNo abstract availableA Minority Within a Minority? Identity and Sexual Health in Black and Minority Ethnic Men Who Have Sex With Men in the United KingdomNo abstract availableTobacco, Alcohol, Drug Use, and Intimate Partner Violence...
08:33
Rapamycin Protects Spiral Ganglion Neurons from Gentamicin-Induced Degeneration In VitroAbstractGentamicin, one of the most widely used aminoglycoside antibiotics, is known to have toxic effects on the inner ear. Taken up by cochlear hair cells and spiral ganglion neurons (SGNs), gentamicin induces the accumulation of reactive oxygen species (ROS) and initiates apoptosis or programmed cell death, resulting in a permanent and irreversible hearing loss. Since the survival of SGNs is specially required...
08:32
A Non-linear Viscoelastic Model of the Incudostapedial JointAbstractThe ossicular joints of the middle ear can significantly affect middle-ear function, particularly under conditions such as high-intensity sound pressures or high quasi-static pressures. Experimental investigations of the mechanical behaviour of the human incudostapedial joint have shown strong non-linearity and asymmetry in tension and compression tests, but some previous finite-element models of the joint have had difficulty replicating...
08:30
Cardiometabolic risk in Algeria: past and presentAbstractAlgeria, like all emerging countries, has been going through a health transition over the past 30 years or so, characterized by a drop in mortality rates, an increase in life expectancy and a change in the causes of death in favor of chronic non-communicable diseases. In the past, the country mainly faced infectious diseases such as typhoid, cholera and malaria. The prevalence of the latter has been significantly reduced thanks to the many...
08:28
Operational effectiveness of three-dimensional flexible endoscopy: an ex vivo study using a new modelAbstractBackground and objectivesTwo-dimensional (2D) images lack depth information and thus provide probabilistic recognition that do not completely match the actual three-dimensional (3D) information. Here, we investigated the operability of 3D endoscopes.MethodsA 3D operation model was developed by passing 20 silk threads through upper and lower plates at 2-mm intervals in front and back rows separated...
08:27
Optimal Dietary Strategies for Prevention of Atherosclerotic Cardiovascular Disease in Diabetes: Evidence and RecommendationsAbstractPurpose of ReviewThis review presents the current available evidence of the effects of several dietary patterns on atherosclerotic cardiovascular disease (ASCVD) risk in patients with type 2 diabetes (T2D).Recent FindingsEvidence demonstrates improvements in cardiovascular risk factors with some dietary patterns in the general population. However, evidence is limited...
08:26
Vorteile bioidentischer Sexualhormone in der systemischen menopausalen HormontherapieZusammenfassungDie ersten Publikationen der Women's-Health-Initiative(WHI)-Studie 2002 und das Bekanntwerden von negativen Auswirkungen einer menopausalen Hormontherapie (MHT) auf die Gesundheit, vor allem im kombinierten Therapiearm mit konjugierten equinen Östrogenen (CEE) plus Medroxyprogesteronacetat (MPA), führten zu einem dramatischen Umdenken in Bezug auf den Einsatz einer MHT. Es wurde nach Alternativen gesucht,...
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Robotics in Laryngeal SurgeryWhile transoral laser microsurgery (TLM) has been the gold standard for laryngeal surgery for many years, recently transoral robotic surgery (TORS) has become a new treatment option not being restricted to a straight line of view which can be an obstacle during resection. In combination with specifically designed retractors TORS can provide a superior visualization and allows tissue manipulation especially in the narrow working space of the larynx. The present article...
08:26
Vaccines, Vol. 7, Pages 157: Knowledge of Human Papillomavirus (HPV), Attitudes and Practices...Vaccines, Vol. 7, Pages 157: Knowledge of Human Papillomavirus (HPV), Attitudes and Practices Towards Anti-HPV Vaccination Among Israeli Pediatricians, Gynecologists, and Internal Medicine Doctors: Development and Validation of an Ad Hoc QuestionnaireVaccines, Vol. 7, Pages 157: Knowledge of Human Papillomavirus (HPV), Attitudes and Practices Towards Anti-HPV Vaccination Among Israeli Pediatricians, Gynecologists,...
Mon Oct 21, 2019 10:47
Vaccines, Vol. 7, Pages 157: Knowledge of Human Papillomavirus (HPV), Attitudes and Practices Towards Anti-HPV Vaccination Among Israeli Pediatricians, Gynecologists, and Internal Medicine Doctors: Development and Validation of an Ad Hoc QuestionnaireVaccines, Vol. 7, Pages 157: Knowledge of Human Papillomavirus (HPV), Attitudes and Practices Towards Anti-HPV Vaccination Among Israeli Pediatricians, Gynecologists, and Internal Medicine Doctors: Development and Validation of an Ad Hoc Questionnaire...
Mon Oct 21, 2019 10:43
Arts, Vol. 8, Pages 138: The Artist's Book in the Age of Digital Reproduction: Walter Benjamin and the Artist's BookArts, Vol. 8, Pages 138: The Artist's Book in the Age of Digital Reproduction: Walter Benjamin and the Artist's Book Arts doi: 10.3390/arts8040138 Authors: Stephen Bury Walter Benjamin, who was familiar with the pre-Second World War avant-garde, argued that mechanization threatens the aura of art objects. The digital revolution has been seen as reconfirming Benjamin's thesis, but the...
Mon Oct 21, 2019 10:43
Vaccines, Vol. 7, Pages 157: Knowledge of Human Papillomavirus (HPV), Attitudes and Practices...Vaccines, Vol. 7, Pages 157: Knowledge of Human Papillomavirus (HPV), Attitudes and Practices Towards Anti-HPV Vaccination Among Israeli Pediatricians, Gynecologists, and Internal Medicine Doctors: Development and Validation of an Ad Hoc QuestionnaireVaccines, Vol. 7, Pages 157: Knowledge of Human Papillomavirus (HPV), Attitudes and Practices Towards Anti-HPV Vaccination Among Israeli Pediatricians, Gynecologists,...
Mon Oct 21, 2019 10:47
Vaccines, Vol. 7, Pages 157: Knowledge of Human Papillomavirus (HPV), Attitudes and Practices...Vaccines, Vol. 7, Pages 157: Knowledge of Human Papillomavirus (HPV), Attitudes and Practices Towards Anti-HPV Vaccination Among Israeli Pediatricians, Gynecologists, and Internal Medicine Doctors: Development and Validation of an Ad Hoc QuestionnaireVaccines, Vol. 7, Pages 157: Knowledge of Human Papillomavirus (HPV), Attitudes and Practices Towards Anti-HPV Vaccination Among Israeli Pediatricians, Gynecologists,...
Mon Oct 21, 2019 10:47
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