Oral and Maxillofacial Pathology

Extracellular matrix in invasion and metastasis of oral squamous cell carcinoma K Vinod Kumar, KN Hema Journal of Oral and Maxillofacial Pathology 2019 23(1):10-16 Oral squamous cell carcinoma is a common cancer in developing countries with highly invasive and metastasis credentials. The Lymphnode metastasis in oral squamous cell carcinoma is regarded as the factor that decides on disease survival of patients. Steps have been made towards research in the field of Oral squamous cell carcinoma for better understanding of the molecular events involved in invasion and metastasis. Recently, the role of Extracellular matrix (ECM) of oral squamous cell carcinoma in invasion and metastasis has gained interest, as ECM is known to actively contribute in events that regulate transcriptional controls and cell signalling mechanisms involved in invasion and metastasis. Understanding such contributing role of ECM may pave way for newer methodologies in early detection, prevention and therapeutic strategies for oral squamous cell carcinoma.

Kamino bodies Deepak Venkatesh, T Smitha Journal of Oral and Maxillofacial Pathology 2019 23(1):17-18

Oral epithelial dysplasia: Classifications and clinical relevance in risk assessment of oral potentially malignant disorders Kannan Ranganathan, Loganathan Kavitha Journal of Oral and Maxillofacial Pathology 2019 23(1):19-27 After more than a decade, the World Health Organization (WHO) published the revised grading system for oral epithelial dysplasia in 2017. The revised classification has changes reflecting our evolution of understanding of the dysplastic process. Although the WHO 2017 three-tier grading system is the gold standard for histological diagnosis of oral potentially malignant disorders, it has certain limitations. Suggestions to overcome these limitations include the use of clinical determinants and molecular markers to supplement the grading system. It has also been suggested that a two-tier system may be more reproducible and clinically translatable for better management. These advances in the understanding of epithelial dysplasia are very important globally and for us in the Indian subcontinent, given the prevalence of habits (tobacco/areca nut) and burden of oral cancer in this part of the world. The following review traces the evolution of the grading system of dysplasia, its relevance and clinical utility.

Identification of Candida albicans using different culture media and its association in leukoplakia and oral squamous cell carcinoma Vivek Gupta, Khare Abhisheik, Shreedhar Balasundari, Niranjan K Devendra, Kalim Shadab, Mahendra Anupama Journal of Oral and Maxillofacial Pathology 2019 23(1):28-35 Context: Candida, leukoplakia and oral squamous cell carcinoma. Aims: The aim of the present study has assessed the association of Candida albicans with normal control group, leukoplakia and oral squamous cell carcinoma lesions of the oral cavity by using cornmeal broth +5% milk and milk serum liquid culture media. Settings and Design: Thepresent study comprised of total 80 patients,which included, 30 patients of Leukoplakia, 30 patients of oral squamous cell carcinoma and normal control group comprised of 20 healthy individuals who were not having any relevant medical, dental and habit history. Subjects and Methods: Saliva and Biopsy was taken from clinically suspected leukoplakia and oral squamous cell carcinoma lesions for the confirmation of histopathological diagnosis. Saliva samples were inoculated for fungal growth in Sabouraud Dextrose Agar, and culture-positive samples had undergone for the germ tube test. Germ tube-positive samples were further taken for chlamydospore production in milk serum and cornmeal broth +5% milk media separately at 8 and 16 h. Statistical Analysis Used: Chi-square test, Fischer extract test. Results: In the normal control group, no fungus growth was found; however, leukoplakia and oral squamous cell carcinoma showed fungus growth with positive germ tube test and chlamydospore formation; the result also showed rapid and quantitatively more chlamydospore formation in cornmeal broth +5% milk in comparison to serum milk culture media. There was no growth of Candida in mild and moderate form of leukoplakia. Whereas in a severe form of leukoplakia, there was more quantitative chlamydospore growth in cornmeal broth +5% milk liquid media. Conclusions: In this study, we have tried to compare the efficacy of cornmeal broth +5% milk and milk serum for the identification of C. albicans. Both the culture media were able to promote the growth of chlamydospore in C. albicans. Among different grades of leukoplakia, the growth of C. albicans was seen in severe dysplastic patient only while mild and moderate dysplasia showed no Candidal growth.

From the Editor's Desk T Smitha Journal of Oral and Maxillofacial Pathology 2019 23(1):1-1

President's Message B Veerendra Kumar Journal of Oral and Maxillofacial Pathology 2019 23(1):2-2

Hon. Secretary's Message Nadeem Jeddy Journal of Oral and Maxillofacial Pathology 2019 23(1):3-3

Hon. Treasurer's Message S Ratheesh Kumar Nandan Journal of Oral and Maxillofacial Pathology 2019 23(1):4-4

Delineating the scope of oral pathology and microbiology: Present scenario and future prospects Bhuvan Nagpal Journal of Oral and Maxillofacial Pathology 2019 23(1):5-7

Prof. (Dr.) R R Paul Mousumi Pal Journal of Oral and Maxillofacial Pathology 2019 23(1):8-9