The association of genetic polymorphisms in serotonin transporter and catechol‐O‐methyltransferase on temporomandibular disorders and anxiety in adolescents

Abstract

Background

Temporomandibular disorder (TMD) is a multifactorial condition involving environmental, psychological, and genetic factors.

Objective

The aim of this case‐control study was to evaluate the influence of genetic polymorphisms in 5HTT and COMT on TMD and anxiety in adolescents.

Methods

TMD was diagnosed and classified according to the RDC/TMD criteria. For case group, the following TMD categories were used: myofascial pain, disc displacement, arthralgia and painful TMD (myofascial and arthralgia). Anxiety levels were assessed according to the State‐Trait Anxiety Inventory. Genomic DNA was extracted and genetic polymorphisms were genotyped by TaqMan chemistry and end‐point analysis. Logistic multivariate regression was used to analyze the associations between TMD types and genotypes, anxiety level and genotypes, using an adjusted odds ratio (OR_a; CI 95%) that considered the gender.

Results

In 5HTT, the rs1042173 was associated with painful TMD (arthralgia and myofascial pain) (OR_c= 1.97; CI 95% 1.02‐3.77; p=0.04). Polymorphisms in COMT rs4818 was significantly associated with myofascial pain (OR_c= 2.15; CI 95% 1.08–4.29; p=0.02) and was borderline for painful TMD (OR_c= 1.85; CI 95% 0.97–3.51; p=0.06) and disc displacement (OR_c= 2.42; CI 95% 1.00–5.87; p=0.05). The rs6269 was borderline for myofascial pain (OR_c= 1.82; CI 95% 0.92–3.59; p=0.08) and disc displacement (OR_c= 2.38; CI 95% 0.95–5.97; p=0.06). Also was associated with anxiety (OR_a= 2.34; CI 95% 1.04–5.25; p=0.03)

Conclusion

Polymorphisms in 5HTT and COMT are associated with TMD in adolescents. Moreover, polymorphism in COMT is associated to anxiety in adolescents.

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