Reply to Liu et al.: Tissue specificity of SIM1 gene expression and erectile dysfunction [Biological Sciences]

In our study (1), we identify a locus in the human genome near the SIM1 gene that is significantly associated with the risk of erectile dysfunction. Through differential enhancer assays, we demonstrate that the lead single-nucleotide polymorphism (SNP), rs17185536, alters enhancer activity. Furthermore, long-range chromatin interaction experiments show that the...

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