Magnetically Controlled Capsule Endoscopy in Children: A Single Center, Retrospective Cohort Study

Objective: Capsule endoscopy (CE) is a noninvasive diagnostic tool for the digestive tract. We aim to investigate the feasibility and safety of newly-developed magnetically controlled capsule endoscopy (MCE) in children. Methods: A total of 129 children who underwent MCE in Shanghai Children's Hospital were retrospectively recruited between March 2016 and August 2018. The feasibility, positive findings, and safety of MCE were evaluated and systematically analyzed. Results: Of all those children, 68 were boys, and 61 were girls with a mean age of 9.8 ± 1.9 years (6–14 years). The MCE procedure was feasible in all children. The mean esophageal transit time was 6.0 ± 4.6 seconds. The mean gastric examination time was 14.4 ± 3.9 minutes, and the average gastric transit time was 83.9 ± 59.1 minutes. Positive findings were detected in 82 children (82/129, 63.6%), 1 had esophageal lesions, 30 had superficial gastritis, 14 had superficial gastritis with bile reflux, 18 had nodular gastritis, 1 had ulcers and 2 had heterotopic pancreas. There were 5 patients who had duodenal bulbar ulcers. One had lymphatic follicle, 1 had celiac disease, 1 had blue rubber bleb nevus syndrome, and 2 polyps were detected in 16 patients who were examined the small bowel. No serious adverse event was reported during the MCE examination and follow-up, and all subjects excreted the capsules spontaneously within 2 weeks. Conclusions: We showed that MCE is feasible and safe in children above 6 years. More studies are needed to further investigate the efficacy of MCE in children. Address correspondence and reprint requests to Haifeng Liu, MD, PhD, Department of Gastroenterology, Hepatology and Nutrition, Shanghai Children's Hospital, Shanghai Jiao Tong University, 355 Luding Road, Shanghai 200062, China (e-mail: haifengliush@aliyun.com). Received 12 November, 2018 Accepted 21 January, 2019 Funding: This work was supported by the grants from the National Natural Science Foundation of China (to Y. Wang, 81500449), and Shanghai Appropriate Health Technology Project of Municipal Hospitals (to H. Liu, SHDC12014224). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Conflicts of Interest: All authors disclosed no conflicts of interest for this article. Supplemental digital content is available for this article. Direct URL citations appear in the printed text, and links to the digital files are provided in the HTML text of this article on the journal's Web site (www.jpgn.org). Z.G. and Y.W. Both authors contributed equally to this study. © 2019 by European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology,

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