Induced pluripotent stem cells in disease modelling and drug discovery

Induced pluripotent stem cells in disease modelling and drug discovery

Induced pluripotent stem cells in disease modelling and drug discovery, Published online: 08 February 2019; doi:10.1038/s41576-019-0100-z

Enthusiasm for patient-specific therapies based on induced pluripotent stem cells (iPSCs) has risen in parallel with rapid advances in genome editing. This Review summarizes the progress in iPSC-based disease modelling over the past decade, with a focus on 3D organoid systems and chimeric models being exploited for new therapeutic approaches.

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