Τρίτη 5 Φεβρουαρίου 2019

Chromatin features constrain structural variation across evolutionary timescales [Genetics]

The potential impact of structural variants includes not only the duplication or deletion of coding sequences, but also the perturbation of noncoding DNA regulatory elements and structural chromatin features, including topological domains (TADs). Structural variants disrupting TAD boundaries have been implicated both in cancer and developmental disease; this likely occurs...

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