Πέμπτη 31 Ιανουαρίου 2019

Widespread interictal epileptic discharge more likely than focal discharges to unveil the seizure onset zone in EEG-fMRI

Publication date: Available online 30 January 2019

Source: Clinical Neurophysiology

Author(s): Tomohiro Yamazoe, Nicolás von Ellenrieder, Hui Ming Khoo, Yao-Hsien Huang, Natalja Zazubovits, François Dubeau, Jean Gotman

Abstract
Objective

We hypothesized that the number of interictal epileptic discharges (IEDs) during scan and their spatial extent are contributing factors in obtaining appropriate activations that reveal the seizure onset zone (SOZ) in EEG-fMRI.

Methods

157 IED types, each corresponding to one EEG scalp distribution, in 64 consecutive EEG-fMRI studies from 64 patients with refractory localization-related epilepsy were reviewed. To determine reliable activation, we used the threshold corresponding to corrected whole-brain topological false discovery rate (FDR). The location with maximum activation was compared to the presumed SOZ as defined by a comprehensive evaluation for each patient.

Results

The number of IEDs was significantly higher in the types with t-value above FDR than with t-value below FDR. The presumed SOZ could be delineated in 30 of the 64 patients. Among these patients, the types of IED concordant with the SOZ had significantly larger extent on scalp EEG than the IED types discordant with the SOZ.

Conclusions

The number of IEDs is important factor in obtaining reliable activations in EEG-fMRI. IEDs with larger spatial extent are more likely to reveal, on maximum BOLD, accurate location of the SOZ.

Significance

Widespread discharges are more likely to yield a reliable activation for SOZ in EEG-fMRI.



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