Anatomy Pathology

 Annals of Diagnostic Pathology

The frequency of <em>NOTCH1</em> variants in T-acute lymphoblastic leukemia/lymphoma and chronic lymphocytic leukemia/small lymphocytic lymphoma among Jordanian patients

Publication date: Available online 24 January 2019Source: Annals of Diagnostic PathologyAuthor(s): Nezeen Z. Abualhaj, Zain Dardas, Belal Azab, Dema Ali, Maher A. Sughayer, Tariq N. Aladily, Mamoun AhramAbstractThe transmembrane receptor NOTCH1 is thought to be associated with the development and progression of T-acute lymphoblastic leukemia (T-ALL)/T-lymphoblastic lymphoma (T-LBL) and chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL). The current study aimed to characterize NOTCH1...

Annals of Diagnostic Pathology

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 Pathology International

Combined hepatocellular‐cholangiocarcinoma with angiosarcomatoid change: A case report with immunohistochemical study

Sarcomatoid combined hepatocellular‐cholangiocarcinoma (cHCC‐CCA) is a rare condition, with only 16 cases reported to date; however, there have been no reports of hepatic sarcomatoid carcinoma with angiosarcomatous features. Here, we report a rare case of cHCC‐CCA with angiosarcomatoid changes in a 77‐year‐old man. The tumor was biphasic with malignant epithelial and mesenchymal components. Histologically, the epithelial component was concordant with classical type cHCC‐CCA. The mesenchymal component...

Pathology International

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Intravascular large B‐cell lymphoma involving large blood vessels, three autopsy cases

Although intravascular large B‐cell lymphoma (IVLBCL) is an extranodal lymphoma characterized by the selective growth of lymphoma cells within the lumina of small vessels, we here report three autopsy cases of IVLBCL characterized by the proliferation within large blood vessels. These three cases were diagnosed as IVLBCL of the bone marrow or skin biopsy. Two cases died suddenly before treatment, whereas the other died during treatment. Autopsies showed a large embolus of dense lymphoma cells extending...

Pathology International

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 Cells Tissues Organs

Whey Protein Complexes with Green Tea Polyphenols: Antimicrobial, Osteoblast-Stimulatory, and Antioxidant Activities

Polyphenols are known for their antimicrobial activity, whilst both polyphenols and the globular protein β-lactoglobulin (bLG) are suggested to have antioxidant properties and promote cell proliferation. These are potentially useful properties for a tissue-engineered construct, though it is unknown if they are retained when both compounds are used in combination. In this study, a range of different microbes and an osteoblast-like cell line (human fetal osteoblast, hFOB) were used to assess the combined...

Cells Tissues Organs

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Two Web Resources Linking Major Human Embryology Collections Worldwide

Human embryology is a core subject for medicine and current research. While animal models of development now have significant online resources available, the vast majority of human embryonic material is locked up in historic collections. When accessed today, these collections are still contributing to our understanding of human development. This paper describes two online resources for studying human development that are unlocking these invaluable collections and providing related human developmental...

Cells Tissues Organs

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 Case Reports in Pathology

A Rare Case of Fibrous Hamartoma of Infancy: A Clinicopathological Diagnosis at a Tertiary Hospital, Eastern Nepal

Background. Fibrous hamartoma of infancy is a rare soft tissue lesion of infants and young children with characteristic triphasic morphology. Case Description. An 18-month-old female child was presented with complaints of swelling over right leg shin since birth. On examination, a lump of size 7x3 cm was identified which was mobile and nontender. Local excision was performed and tissue sent for histopathological examination. On gross examination, a globular, capsulated, firm to hard tissue had cut...

Case Reports in Pathology

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 Cancer Cytopathology

The prevalence and surgical outcomes of Hurthle cell lesions in FNAs of the thyroid: A multi‐institutional study in 6 Asian countries

Background Hurthle cell‐rich nodules (HCNs) encompass non‐neoplastic to malignant lesions. There is paucity of literature on the frequency distribution of HCNs among Bethesda categories, histologic follow‐up, risk of malignancy (ROM), and risk of neoplasia (RON). The objective of this retrospective, multi‐institutional study was to determine the prevalence of the cytologic diagnostic category and surgical outcomes of patients with HCN. Methods Nine tertiary health centers representing 6 Asian...

Cancer Cytopathology

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Negative predictive value and sensitivity of urine cytology prior to implementation of The Paris System for Reporting Urinary Cytology

Background Urinary tract cytology (UTCy) is used for screening urothelial carcinoma (UC) and it must have a high negative predictive value (NPV) to be an effective test. To the authors' knowledge, the literature regarding the NPV of UTCy provides little information regarding the risk of malignancy, especially for patients with high‐grade urothelial carcinoma (HGUC). Methods Patients with negative UTCy specimens were identified in the pathology files at the study institution for the years 2012...

Cancer Cytopathology

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The value of cytology in the management of patients with pancreatic cysts

Cancer Cytopathology

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