OBJECTIVE To investigate the overall estimates of cross-sectional areas (CSA) of the median nerve measured by ultrasonography in accordance with the electrodiagnostic classification of carpal tunnel syndrome (CTS) severity. DESIGN MEDLINE (PubMed), EMBASE (Ovid), and Web of Science were searched for studies reporting the median nerve CSA measured by ultrasonography for mild, moderate and severe CTS based on electrodiagnostic study. CSA values measured at the carpal tunnel inlet were included in the analyses. RESULTS Overall, 866 citations were retrieved and checked for eligibility. Finally, 16 articles were included for meta-analysis. These studies included a total sample of 2,292 wrists including 776 mild, 823 moderate and 693 severe CTS. The pooled analysis revealed a mean CSA of 11.64 mm2 (95% CI: 11.23-12.05 mm2; P
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