Experience of Using A Semi-Elemental Formula For Home Enteral Nutrition In Children: A Multicenter Cross-Sectional Study

Objectives: The use of semi-elemental diets concerns a small proportion of children on enteral nutrition whose characteristics have never been reported. Our aim was to describe a cohort of patients on home enteral nutrition with Peptamen Junior®, including the tolerance and nutritional efficacy of this product. Methods: We performed a retrospective multicenter survey on a cohort of patients receiving this semi-elemental diet at home between 2010 and 2015 in 14 tertiary pediatric French centers. We recorded at baseline, 3, 6 and 12 months, and then every year the anthropometric characteristics of the patients, indications and modalities of administration of the diet, and the tolerance and adverse events. Results: We recruited 136 patients aged 9.8 ± 4.4 years at baseline. Mean BMI z-score was −1.0 ± 1.8; mean height z-score was −1.1 ± 1.9. The main underlying diseases were digestive (35.3%), neurological (33.1%), and haematological (19.9%). The indications for a semi-elemental diet were failure of another diet in 70 patients (51.9%), severe malnutrition in 19 (14.1%), cystic fibrosis in 11 (8.1%) and switch from parenteral nutrition in 11 (8.1%). Side effects were observed in 39.2% of the patients, and required medical attention in 8.2%. Body mass index improved or remained normal in 88.3% of children. Conclusions: This semi-elemental diet seems to be well tolerated and efficient in the setting of home enteral nutrition in children with complex diseases featuring malabsorption and/or after failure of polymeric diet. Address correspondence and reprint requests to Marie Leonard, MD, Unité de Gastroentérologie et Nutrition pédiatrique, Département de pédiatrie, Hôpital Jeanne de Flandre, Avenue Eugène Avinée, 59037 Lille Cedex, France (e-mail: marie.leonard.be@gmail.com). Received 22 August, 2018 Accepted 21 November, 2018 Trial identification number: This study was not registered since it is a retrospective study. Financial support: This work was supported by Nestlé Health Science. Conflicts of interest: F. Gottrand and D. Guimber were scientific advisors of this study and received fees from Nestlé Health Science. J. Gautry is employee at Nestlé Health Science. © 2018 by European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology,

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