Acute High-Intensity Interval Exercise in Multiple Sclerosis with Mobility Disability

INTRODUCTION Multiple sclerosis(MS) is an immune-mediated, neurological disease that results in physiological deconditioning with increasing disability. High-intensity interval training exercise(HIIT) has induced significant improvements in physiological conditioning in healthy and clinical populations, and might be appropriate for persons with MS who have mobility disability. The feasibility and acute effects of HIIT using recumbent stepping in persons with MS who have mobility disability are relatively unknown. METHODS The physiological effects of single sessions of HIIT and continuous(CON), steady-state aerobic exercise using recumbent stepping were compared in 20 persons with MS with mobility disability(i.e., EDSS of 4.0-6.5). The HIIT bout included 10 cycles of one-minute intervals at the work rate associated with 90% VO2peak followed by one-minute recovery intervals at 15W, totaling 20 minutes in length. The CON bout consisted of 20 minutes at the work rate associated with 50-60% VO2peak. Physiological(i.e., power output, oxygen consumption, carbon dioxide expiration, respiratory exchange ratio, ventilation, heart rate, and core temperature) and perceptual(i.e., ratings of perceived exertion) measures were collected across the acute sessions. RESULTS There were statistically significant condition × time interactions for all physiological measures and ratings of perceived exertion expressing differential patterns of change over time for HIIT versus CON(p<.05 the main effect of condition was significant for all physiological outcomes except core temperature with hiit inducing significantly higher values than con conclusions exercise taxes cardiorespiratory system more yet without deleterious effects on in persons ms. this has important implications informing an evidence-based prescription that is appropriate improving conditioning ms who have mobility disabilities. corresponding author: elizabeth a. hubbard po box mount berry ga telephone: fax: email: lhubbard authors do not any conflicts interest. there are no funding sources present study. results study constitute endorsement by acsm. presented clearly honestly and fabrication falsification or inappropriate data manipulation. accepted publication november american college sports medicine>

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