Neurophysiological effects of continuous cortical stimulation in epilepsy – spike and spontaneous ECoG activity

Epilepsy constitutes a wide range of brain disorders characterized by a predisposition of developing seizures. Approximately thirty percent of patients with focal epilepsy do not respond adequately to antiepileptic drugs and develop pharmacoresistant epilepsy, sometimes experiencing multiple daily seizures (Abramovici and Bagic 2016), as well as an increased risk of premature death, neurological deficits and reduced quality of life (Chen et al. 2016). Amongst focal drug-resistant epilepsies, surgical resection of the epileptogenic zone provides a good outcome in a majority of cases (West et al.

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