Efficiency of dual siRNA mediated gene therapy for intervertebral disc degeneration (IVDD)

One of the common causes of LBP is intervertebral disc degeneration. The pathophysiology of disc degeneration involves apoptosis of nucleus pulposes (NP) cells and degradation of extra cellular matrix (ECM). Caspase 3 plays a central role in apoptosis and the ADAMTS 5 (A Disintegrin and Metalloproteinase with Thrombospondin motifs) gene plays a critical role in ECM degradation. Hence, we hypothesized that if one can silence these two genes, both apoptosis and ECM degradation can be prevented, thereby preventing the progression and even reverse disc degeneration.

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